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| | NCU07891 | Endo/exonuclease/phosphatase domain-containing protein. (446 aa) |
| | dcl-1 | ATP-dependent helicase dcl-1; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume. (1584 aa) |
| | NCU08648 | Nuclease PA3. (306 aa) |
| | rex-4 | RNA exonuclease 4; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity); Belongs to the REXO4 family. (406 aa) |
| | NCU06345 | Tyrosyl-DNA phosphodiesterase. (661 aa) |
| | NCU08299 | 60S ribosomal protein L3. (439 aa) |
| | tsp-4 | Probable tRNA-splicing endonuclease subunit tsp-4; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant [...] (315 aa) |
| | NCU06222 | Tyrosyl-DNA phosphodiesterase domain-containing protein. (691 aa) |
| | NCU05341 | Endo/exonuclease/phosphatase domain-containing protein. (299 aa) |
| | tsp-5 | Probable tRNA-splicing endonuclease subunit tsp-5; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of th [...] (557 aa) |
| | dcl-2 | ATP-dependent helicase dcl-2; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume. (1534 aa) |
| | NCU03065 | Mitotic control protein dis3; Belongs to the RNR ribonuclease family. (984 aa) |
| | mus-81 | Crossover junction endonuclease mus-81; Interacts with eme-1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (645 aa) |
| | NCU08602 | Uncharacterized protein. (87 aa) |
| | NCU03036 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (885 aa) |
| | NCU02134 | Transcription factor. (880 aa) |
| | usb1 | U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (364 aa) |
| | slx4 | Structure-specific endonuclease subunit slx4; Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (1013 aa) |
| | NCU09077 | Rpr2 domain-containing protein. (267 aa) |
| | mus-40 | DNA excision repair protein Rad2. (1269 aa) |
| | NCU08368 | Ribonuclease P complex subunit Pop2. (382 aa) |
| | NCU02961 | Exonuclease. (716 aa) |
| | NCU02675 | RNA-3'-phosphate cyclase. (406 aa) |
| | NCU02928 | Uncharacterized protein. (1196 aa) |
| | NCU00690 | Ribonuclease P complex subunit Pop1. (930 aa) |
| | ysh-1 | Endoribonuclease ysh-1; Component of the cleavage factor I (CF I) involved in pre- mRNA 3'-end processing; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily. (850 aa) |
| | exr-1 | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity); Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (1072 aa) |
| | mus-23 | Double-strand break repair protein mus-23; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity); Belongs to the MRE11/RAD32 family. (739 aa) |
| | ccr4 | Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (793 aa) |
| | rai1 | Decapping nuclease rai1; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). Belongs to the DXO/Dom3Z family. (412 aa) |
| | rnh-201 | Ribonuclease H2 subunit A; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication. (317 aa) |
| | tsp-2 | Probable tRNA-splicing endonuclease subunit tsp-2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant [...] (633 aa) |
| | slx1 | Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (402 aa) |
| | NCU09855 | Nicotianamine synthase. (339 aa) |
| | NCU05966 | DNA repair protein. (603 aa) |
| | NCU07559 | Uncharacterized protein. (499 aa) |
| | NCU07381 | DNA cross-link repair protein pso2/snm1. (1031 aa) |
| | NCU09001 | CCR4-NOT transcription complex subunit 7. (572 aa) |
| | NCU11241 | Nuclease domain-containing protein. (379 aa) |
| | dnr-8 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (394 aa) |
| | NCU11261 | Uncharacterized protein. (317 aa) |
| | NCU10622 | Uncharacterized protein. (221 aa) |
| | NCU03538 | Deoxyribonuclease tatD. (508 aa) |
| | NCU16026 | Laglidadg endonuclease. (480 aa) |
| | grn | Guanyl-specific ribonuclease N1. (153 aa) |
| | par-1 | PAN2-PAN3 deadenylation complex catalytic subunit pan2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pabp-1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequen [...] (1310 aa) |
| | bI3 | Cytochrome b mRNA maturase bI3; Mitochondrial mRNA maturase required for splicing of intron 3 of the cytochrome b (cob) gene, containing its own coding sequence. In the C-terminal section; belongs to the LAGLIDADG endonuclease family. (477 aa) |
| | cyt-4 | Mitochondrial protein cyt-4; Required for RNA 5'- and 3'-end processing and splicing. May act on the RNA processing enzymes directly, or it may act on other regulatory molecules, which influence the activity or synthesis of these enzymes. (1117 aa) |
| | mus-18 | UV-damage endonuclease; Endonuclease for the repair of UV-irradiated DNA. Involved in the excision of cyclobutane pyrimidine dimers (CPD) and 6-4 pyrimidine pyrimidones (6-4PP) which forms the UV damage repair (UVDR) pathway; Belongs to the uve1/UvsE family. (656 aa) |
| | NCU03409 | RNA lariat debranching enzyme. (617 aa) |
| | sms-2 | Meiotic silencing suppressor 2; Belongs to the argonaute family. (989 aa) |
| | NCU09194 | Nuclease S1. (324 aa) |
| | NCU03662 | Uncharacterized protein. (745 aa) |
| | NCU08945 | RNA exonuclease 3. (690 aa) |
| | NCU03747 | Uncharacterized protein. (374 aa) |
| | NCU04159 | DUF652 domain-containing protein. (194 aa) |
| | NCU03682 | Endonuclease/exonuclease/phosphatase. (289 aa) |
| | NCU01203 | Uncharacterized protein. (231 aa) |
| | gul-1 | Cell wall biogenesis protein phosphatase Ssd1. (1365 aa) |
| | pold-1 | DNA polymerase. (1104 aa) |
| | bI1 | Probable intron-encoded endonuclease bI1; Mitochondrial DNA endonuclease involved in intron homing. (448 aa) |
| | NCU16009 | Probable intron-encoded endonuclease 2; Mitochondrial DNA endonuclease involved in intron homing. In the C-terminal section; belongs to the LAGLIDADG endonuclease family. (452 aa) |
| | NCU16010 | Probable intron-encoded endonuclease 3; Mitochondrial DNA endonuclease involved in intron homing. In the C-terminal section; belongs to the LAGLIDADG endonuclease family. (533 aa) |
| | NCU16011 | Probable intron-encoded endonuclease 4; Mitochondrial DNA endonuclease involved in intron homing. In the C-terminal section; belongs to the LAGLIDADG endonuclease family. (545 aa) |
| | NCU16019 | Probable intron-encoded endonuclease 1; Mitochondrial DNA endonuclease involved in intron homing. (304 aa) |
| | NCU03765 | 3'-5' exonuclease/helicase. (753 aa) |
| | mus-38 | MUS38. (960 aa) |
| | NCU04450 | Exonuclease V, mitochondrial; Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively. (657 aa) |
| | NCU05006 | Cytochrome P450. (461 aa) |
| | NCU04548 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2259 aa) |
| | NCU04091 | Uncharacterized protein. (422 aa) |
| | NCU05036 | Exonuclease domain-containing protein. (343 aa) |
| | NCU16422 | Uncharacterized protein. (79 aa) |
| | NCU16423 | Uncharacterized protein. (378 aa) |
| | NCU16377 | Oligoribonuclease. (198 aa) |
| | NCU16461 | Uncharacterized protein. (170 aa) |
| | NCU01762 | Nucleolar RNAse III, variant. (352 aa) |
| | NCU16387 | XPGI domain-containing protein. (226 aa) |
| | NCU08705 | Uncharacterized protein. (1071 aa) |
| | NCU16891 | Uncharacterized protein. (294 aa) |
| | NCU01961 | DNA lyase Apn2. (655 aa) |
| | NCU16771 | Rpp14 family protein. (187 aa) |
| | NCU03338 | SAP domain-containing protein. (497 aa) |
| | NCU04749 | DNA replication helicase Dna2. (1727 aa) |
| | qde-2 | Post-transcriptional silencing protein QDE-2. (1089 aa) |
| | NCU00422 | Curved DNA-binding protein, variant. (410 aa) |
| | NCU16705 | Chromo domain-containing protein. (145 aa) |
| | mip-1 | DNA polymerase gamma, mitochondrial; Involved in the replication of mitochondrial DNA. (1456 aa) |
| | stk-14 | Serine/threonine kinase IREI. (1208 aa) |
| | NCU06089 | Exonuclease. (758 aa) |
| | NCU05750 | Ribonuclease H. (498 aa) |
| | trax | TRAX. (355 aa) |
| | NCU02256 | Exosome complex exonuclease Rrp6. (822 aa) |
| | mus-44 | Mating-type switching protein swi10. (405 aa) |
| | NCU04740 | Uncharacterized protein. (434 aa) |
| | NCU06678 | 5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1450 aa) |
| | NCU06572 | zf-C2HE domain-containing protein. (299 aa) |
| | NCU05253 | XPG_I_2 domain-containing protein. (574 aa) |
| | NCU03564 | Flap structure-specific endonuclease. (1037 aa) |
| | NCU00426 | Lactamase_B domain-containing protein. (359 aa) |
| | NCU00030 | Endonuclease. (332 aa) |
| | NCU04408 | Uncharacterized protein. (355 aa) |
| | NCU00319 | Uncharacterized protein. (242 aa) |
| | NCU00293 | NADH pyrophosphatase. (511 aa) |
| | NCU00232 | Lactamase_B_4 domain-containing protein. (1099 aa) |
| | NCU08904 | 20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (440 aa) |
