STRINGSTRING
NCU08602 NCU08602 trax trax mus-44 mus-44 NCU04740 NCU04740 NCU07891 NCU07891 dcl-1 dcl-1 NCU08648 NCU08648 NCU08299 NCU08299 tsp-4 tsp-4 tsp-5 tsp-5 dcl-2 dcl-2 mus-81 mus-81 NCU03036 NCU03036 slx4 slx4 NCU09077 NCU09077 mus-40 mus-40 NCU08368 NCU08368 NCU02675 NCU02675 NCU02928 NCU02928 NCU00690 NCU00690 ysh-1 ysh-1 mus-23 mus-23 rnh-201 rnh-201 tsp-2 tsp-2 slx1 slx1 NCU16705 NCU16705 qde-2 qde-2 NCU04749 NCU04749 NCU03338 NCU03338 NCU16771 NCU16771 NCU01961 NCU01961 NCU16891 NCU16891 NCU16387 NCU16387 NCU01762 NCU01762 NCU16461 NCU16461 NCU11241 NCU11241 dnr-8 dnr-8 NCU11261 NCU11261 NCU10622 NCU10622 NCU16026 NCU16026 grn grn bI3 bI3 mus-18 mus-18 NCU03409 NCU03409 sms-2 sms-2 NCU09194 NCU09194 NCU03662 NCU03662 NCU03747 NCU03747 NCU04159 NCU04159 bI1 bI1 NCU16009 NCU16009 NCU16010 NCU16010 NCU16011 NCU16011 NCU16019 NCU16019 mus-38 mus-38 NCU05006 NCU05006 NCU04091 NCU04091 NCU03564 NCU03564 NCU00426 NCU00426 NCU00030 NCU00030 NCU04408 NCU04408 NCU00319 NCU00319 NCU00293 NCU00293 NCU00232 NCU00232 NCU08904 NCU08904 NCU09855 NCU09855 NCU05966 NCU05966 stk-14 stk-14 NCU06089 NCU06089 NCU05750 NCU05750
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU08602Uncharacterized protein. (87 aa)
traxTRAX. (355 aa)
mus-44Mating-type switching protein swi10. (405 aa)
NCU04740Uncharacterized protein. (434 aa)
NCU07891Endo/exonuclease/phosphatase domain-containing protein. (446 aa)
dcl-1ATP-dependent helicase dcl-1; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume. (1584 aa)
NCU08648Nuclease PA3. (306 aa)
NCU0829960S ribosomal protein L3. (439 aa)
tsp-4Probable tRNA-splicing endonuclease subunit tsp-4; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant [...] (315 aa)
tsp-5Probable tRNA-splicing endonuclease subunit tsp-5; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of th [...] (557 aa)
dcl-2ATP-dependent helicase dcl-2; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume. (1534 aa)
mus-81Crossover junction endonuclease mus-81; Interacts with eme-1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (645 aa)
NCU03036Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (885 aa)
slx4Structure-specific endonuclease subunit slx4; Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (1013 aa)
NCU09077Rpr2 domain-containing protein. (267 aa)
mus-40DNA excision repair protein Rad2. (1269 aa)
NCU08368Ribonuclease P complex subunit Pop2. (382 aa)
NCU02675RNA-3'-phosphate cyclase. (406 aa)
NCU02928Uncharacterized protein. (1196 aa)
NCU00690Ribonuclease P complex subunit Pop1. (930 aa)
ysh-1Endoribonuclease ysh-1; Component of the cleavage factor I (CF I) involved in pre- mRNA 3'-end processing; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily. (850 aa)
mus-23Double-strand break repair protein mus-23; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity); Belongs to the MRE11/RAD32 family. (739 aa)
rnh-201Ribonuclease H2 subunit A; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication. (317 aa)
tsp-2Probable tRNA-splicing endonuclease subunit tsp-2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant [...] (633 aa)
slx1Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (402 aa)
NCU16705Chromo domain-containing protein. (145 aa)
qde-2Post-transcriptional silencing protein QDE-2. (1089 aa)
NCU04749DNA replication helicase Dna2. (1727 aa)
NCU03338SAP domain-containing protein. (497 aa)
NCU16771Rpp14 family protein. (187 aa)
NCU01961DNA lyase Apn2. (655 aa)
NCU16891Uncharacterized protein. (294 aa)
NCU16387XPGI domain-containing protein. (226 aa)
NCU01762Nucleolar RNAse III, variant. (352 aa)
NCU16461Uncharacterized protein. (170 aa)
NCU11241Nuclease domain-containing protein. (379 aa)
dnr-8Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (394 aa)
NCU11261Uncharacterized protein. (317 aa)
NCU10622Uncharacterized protein. (221 aa)
NCU16026Laglidadg endonuclease. (480 aa)
grnGuanyl-specific ribonuclease N1. (153 aa)
bI3Cytochrome b mRNA maturase bI3; Mitochondrial mRNA maturase required for splicing of intron 3 of the cytochrome b (cob) gene, containing its own coding sequence. In the C-terminal section; belongs to the LAGLIDADG endonuclease family. (477 aa)
mus-18UV-damage endonuclease; Endonuclease for the repair of UV-irradiated DNA. Involved in the excision of cyclobutane pyrimidine dimers (CPD) and 6-4 pyrimidine pyrimidones (6-4PP) which forms the UV damage repair (UVDR) pathway; Belongs to the uve1/UvsE family. (656 aa)
NCU03409RNA lariat debranching enzyme. (617 aa)
sms-2Meiotic silencing suppressor 2; Belongs to the argonaute family. (989 aa)
NCU09194Nuclease S1. (324 aa)
NCU03662Uncharacterized protein. (745 aa)
NCU03747Uncharacterized protein. (374 aa)
NCU04159DUF652 domain-containing protein. (194 aa)
bI1Probable intron-encoded endonuclease bI1; Mitochondrial DNA endonuclease involved in intron homing. (448 aa)
NCU16009Probable intron-encoded endonuclease 2; Mitochondrial DNA endonuclease involved in intron homing. In the C-terminal section; belongs to the LAGLIDADG endonuclease family. (452 aa)
NCU16010Probable intron-encoded endonuclease 3; Mitochondrial DNA endonuclease involved in intron homing. In the C-terminal section; belongs to the LAGLIDADG endonuclease family. (533 aa)
NCU16011Probable intron-encoded endonuclease 4; Mitochondrial DNA endonuclease involved in intron homing. In the C-terminal section; belongs to the LAGLIDADG endonuclease family. (545 aa)
NCU16019Probable intron-encoded endonuclease 1; Mitochondrial DNA endonuclease involved in intron homing. (304 aa)
mus-38MUS38. (960 aa)
NCU05006Cytochrome P450. (461 aa)
NCU04091Uncharacterized protein. (422 aa)
NCU03564Flap structure-specific endonuclease. (1037 aa)
NCU00426Lactamase_B domain-containing protein. (359 aa)
NCU00030Endonuclease. (332 aa)
NCU04408Uncharacterized protein. (355 aa)
NCU00319Uncharacterized protein. (242 aa)
NCU00293NADH pyrophosphatase. (511 aa)
NCU00232Lactamase_B_4 domain-containing protein. (1099 aa)
NCU0890420S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (440 aa)
NCU09855Nicotianamine synthase. (339 aa)
NCU05966DNA repair protein. (603 aa)
stk-14Serine/threonine kinase IREI. (1208 aa)
NCU06089Exonuclease. (758 aa)
NCU05750Ribonuclease H. (498 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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