STRINGSTRING
NCU11174 NCU11174 NCU11209 NCU11209 NCU11085 NCU11085 NCU10507 NCU10507 NCU10506 NCU10506 NCU10430 NCU10430 NCU10400 NCU10400 NCU01523 NCU01523 NCU04137 NCU04137 NCU01250 NCU01250 NCU03898 NCU03898 NCU01575 NCU01575 NCU01791 NCU01791 NCU03383 NCU03383 NCU04014 NCU04014 NCU04598 NCU04598 NCU04652 NCU04652 NCU04165 NCU04165 NCU06715 NCU06715 NCU06713 NCU06713 NCU04281 NCU04281 NCU04188 NCU04188 NCU03818 NCU03818 syn-2 syn-2 NCU04119 NCU04119 NCU03645 NCU03645 NCU03631 NCU03631 NCU01330 NCU01330 NCU01058 NCU01058 NCU01047 NCU01047 PSD2 PSD2 NCU03947 NCU03947 NCU04355 NCU04355 NCU01822 NCU01822 NCU06410 NCU06410 NCU04541 NCU04541 NCU08761 NCU08761 NCU00435 NCU00435 NCU00453 NCU00453 NCU00121 NCU00121 NCU06473 NCU06473 NCU06444 NCU06444 atg15 atg15 NCU03955 NCU03955 vps27 vps27 cpr-8 cpr-8 NCU00242 NCU00242 NCU09535 NCU09535 NCU06942 NCU06942 NCU06939 NCU06939 NCU05959 NCU05959 NCU09543 NCU09543 NCU09121 NCU09121 NCU09219 NCU09219 ptr-1 ptr-1 NCU05902 NCU05902 NCU05899 NCU05899 NCU06084 NCU06084 NCU02225 NCU02225 NCU05753 NCU05753 prr-1 prr-1 NCU05837 NCU05837 NCU05634 NCU05634 NCU07061 NCU07061 NCU04783 NCU04783 hse1 hse1 NCU08874 NCU08874 NCU04100 NCU04100 NCU01199 NCU01199 NCU05230 NCU05230 NCU07020 NCU07020 stk-45 stk-45 NCU06595 NCU06595 end-3 end-3 NCU06342 NCU06342 NCU06284 NCU06284 NCU06988 NCU06988 bro-1 bro-1 NCU07991 NCU07991 pan-1 pan-1 vsp-6 vsp-6 NCU06257 NCU06257 NCU06268 NCU06268 vsp-1 vsp-1 NCU06212 NCU06212 NCU07823 NCU07823 NCU07584 NCU07584 NCU06183 NCU06183 NCU06181 NCU06181 NCU08538 NCU08538 NCU07843 NCU07843 NCU09469 NCU09469 NCU05422 NCU05422 NCU02847 NCU02847 NCU02846 NCU02846 NCU00753 NCU00753 NCU00814 NCU00814 NCU00725 NCU00725 NCU02083 NCU02083 NCU07435 NCU07435 NCU02048 NCU02048 NCU00566 NCU00566 NCU00895 NCU00895 NCU08618 NCU08618 NCU02019 NCU02019 NCU07492 NCU07492 NCU02743 NCU02743 NCU08360 NCU08360 NCU03221 NCU03221 vsp-5 vsp-5 NCU03205 NCU03205 NCU03024 NCU03024 snx-3 snx-3 NCU01903 NCU01903 NCU02554 NCU02554 NCU00696 NCU00696 NCU00656 NCU00656 apg-13 apg-13 vsp-3 vsp-3 apg-10 apg-10 ssh4 ssh4 17E5.300 17E5.300 NCU06176 NCU06176 NCU02409 NCU02409 NCU05796 NCU05796 pod-2 pod-2 NCU06624 NCU06624 NCU05195 NCU05195 NCU01854 NCU01854 NCU03063 NCU03063 NCU03122 NCU03122 NCU02978 NCU02978
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU11174MIP-2A. (210 aa)
NCU11209Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (237 aa)
NCU11085Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (161 aa)
NCU10507Uncharacterized protein. (184 aa)
NCU10506Triacylglycerol lipase FGL2. (509 aa)
NCU10430SNF7 family protein. (215 aa)
NCU10400Phospholipase. (912 aa)
NCU01523GTP-binding protein ypt3. (214 aa)
NCU04137Vacuolar protein sorting-associated protein Vps5. (580 aa)
NCU01250Cystinosin. (297 aa)
NCU03898ESCRT-II complex component. (225 aa)
NCU01575SNARE complex subunit. (292 aa)
NCU01791SNF7 family protein. (235 aa)
NCU03383KxDL domain-containing protein. (193 aa)
NCU04014Uncharacterized protein. (1116 aa)
NCU04598Uncharacterized protein. (1136 aa)
NCU04652AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1060 aa)
NCU04165Low-temperature viability protein ltv1. (417 aa)
NCU06715Uncharacterized protein. (1454 aa)
NCU06713Vacuolar protein sorting protein 55. (128 aa)
NCU04281WD-repeat protein pop3. (318 aa)
NCU04188UPF0220 domain-containing protein. (173 aa)
NCU03818Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1331 aa)
syn-2Syntaxin 2. (335 aa)
NCU04119SNARE complex subunit; Belongs to the syntaxin family. (362 aa)
NCU03645GAR domain-containing protein. (941 aa)
NCU03631NTF2 domain-containing protein. (188 aa)
NCU01330SacI domain-containing protein. (1011 aa)
NCU01058Uncharacterized protein. (604 aa)
NCU01047IPPc domain-containing protein. (1053 aa)
PSD2Phosphatidylserine decarboxylase 2 alpha chain; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily. (1062 aa)
NCU03947E3 ubiquitin-protein ligase. (817 aa)
NCU04355Phosphatidylinositol 4-kinase type II subunit alpha. (867 aa)
NCU01822Vacuolar protein sorting-associated protein 29; Belongs to the VPS29 family. (239 aa)
NCU06410GTP-binding protein YPT52. (236 aa)
NCU04541SNF7 family protein. (218 aa)
NCU08761Vacuolar sorting receptor. (370 aa)
NCU00435SNF7 family protein. (227 aa)
NCU00453Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (663 aa)
NCU00121CLC channel protein. (920 aa)
NCU06473ZIP metal ion transporter. (430 aa)
NCU06444Chloride channel protein. (922 aa)
atg15Putative lipase atg15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by atg15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (647 aa)
NCU03955Phospholipase. (1885 aa)
vps27Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. (724 aa)
cpr-8Calpain-like protease palB/cpr-8; Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH. (932 aa)
NCU00242V-SNARE. (562 aa)
NCU09535DAO domain-containing protein. (493 aa)
NCU06942Vacuolar protein sorting-associated protein VPS4; Belongs to the AAA ATPase family. (441 aa)
NCU06939Endosome-associated ubiquitin isopeptidase. (586 aa)
NCU05959Vesicle transport V-SNARE protein VTI1. (228 aa)
NCU09543PQ loop repeat protein. (285 aa)
NCU09121Vacuolar sorting protein; Belongs to the STXBP/unc-18/SEC1 family. (666 aa)
NCU09219Dopey domain-containing protein. (1922 aa)
ptr-1Palmitoyltransferase akr1; Palmitoyltransferase specific for casein kinase 1. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. (729 aa)
NCU05902Vacuolar assembly protein. (1359 aa)
NCU05899Flotillin domain-containing protein; Belongs to the band 7/mec-2 family. Flotillin subfamily. (525 aa)
NCU06084Uncharacterized protein. (347 aa)
NCU02225Uncharacterized protein. (1631 aa)
NCU05753ESCRT-I component. (580 aa)
prr-1pH-response regulator protein palA/prr-1; Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease palB/cpr-8 via snf7/vps-3 to its substrate pacc-1 (By similarity); Belongs to the palA/RIM20 family. (854 aa)
NCU05837Vacuolar protein sorting-associated protein; May be involved in recycling of membrane proteins between an endocytic compartment and the TGN; Belongs to the VPS13 family. (3209 aa)
NCU05634Uncharacterized protein. (1765 aa)
NCU07061Uncharacterized protein. (177 aa)
NCU04783EH domain binding protein epsin 2. (597 aa)
hse1Class E vacuolar protein-sorting machinery protein hse1; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB). (745 aa)
NCU08874Trafficking protein particle complex subunit; Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. (244 aa)
NCU04100Vacuolar sorting protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (706 aa)
NCU01199SNARE domain-containing protein. (259 aa)
NCU05230MARVEL domain-containing protein. (189 aa)
NCU07020Vacuolar protein sorting-associated protein vps17. (662 aa)
stk-45Phosphoinositide 3-kinase regulatory subunit 4. (1563 aa)
NCU06595Vacuolar protein sorting protein. (637 aa)
end-3Actin cytoskeleton-regulatory complex protein end-3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (396 aa)
NCU06342Phospholipase. (978 aa)
NCU06284Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (881 aa)
NCU06988Spc97/Spc98 family protein. (1362 aa)
bro-1Vacuolar protein-sorting protein bro-1; Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles; Belongs to the BRO1 family. (1012 aa)
NCU07991DUF292 domain-containing protein. (299 aa)
pan-1Actin cytoskeleton-regulatory complex protein pan-1; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (1533 aa)
vsp-6Sorting nexin-41; May be required for cytoplasm to vacuole transport (Cvt) and pexophagy. (619 aa)
NCU06257Rab-GAP TBC domain-containing protein. (905 aa)
NCU06268Probable vacuolar protein sorting-associated protein 16 homolog; Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. (865 aa)
vsp-1Sorting nexin mvp1; Required for vacuolar protein sorting. (790 aa)
NCU06212Trafficking protein particle complex subunit 6B. (262 aa)
NCU07823Scytalone dehydratase; Belongs to the scytalone dehydratase family. (174 aa)
NCU07584Vacuolar segregation protein pep7. (685 aa)
NCU06183Vacuolar protein sorting protein DigA. (973 aa)
NCU06181Uncharacterized protein. (1468 aa)
NCU08538HNHc domain-containing protein. (407 aa)
NCU07843Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (267 aa)
NCU09469EF hand domain-containing protein. (1286 aa)
NCU05422E3 ubiquitin-protein ligase PEP5. (1016 aa)
NCU02847Uncharacterized protein. (353 aa)
NCU02846Uncharacterized protein. (731 aa)
NCU00753Uncharacterized protein. (444 aa)
NCU00814Uncharacterized protein. (430 aa)
NCU00725Epsin-3. (521 aa)
NCU020831-phosphatidylinositol-3-phosphate 5-kinase. (2558 aa)
NCU07435Chitin biosynthesis protein CHS5. (454 aa)
NCU02048VPS9 domain-containing protein. (1345 aa)
NCU00566Synaptobrevin. (116 aa)
NCU00895RAB GTPase Ypt5. (220 aa)
NCU08618ADP-ribosylation factor family protein; Belongs to the small GTPase superfamily. Arf family. (183 aa)
NCU02019FAD dependent oxidoreductase. (453 aa)
NCU07492Uncharacterized protein. (1245 aa)
NCU02743Vacuolar protein sorting protein 26. (327 aa)
NCU08360Uncharacterized protein. (668 aa)
NCU03221PX domain-containing protein. (274 aa)
vsp-5Sorting nexin-4; Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans- Golgi network, for cytoplasm to vacuole transport (Cvt), mitophagy, and pexophagy (By similarity). (493 aa)
NCU03205Uncharacterized protein. (188 aa)
NCU03024GARP complex subunit Vps53. (857 aa)
snx-3Sorting nexin-3; Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity). (142 aa)
NCU01903Pigment biosynthesis protein Ayg1. (487 aa)
NCU02554Golgi complex component. (1669 aa)
NCU00696SH3 domain-containing protein. (329 aa)
NCU00656Phosphatidylinositol 3-kinase VPS34. (914 aa)
apg-13Vacuolar fusion protein mon1; Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis; Belongs to the MON1/SAND family. (678 aa)
vsp-3Vacuolar-sorting protein snf7; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH (By similarity). (228 aa)
apg-10Autophagy-related protein 18; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation- induced autophagy. Involved in correct apg-7/atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). (436 aa)
ssh4Protein ssh4; Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity); Belongs to the SSH4 family. (503 aa)
17E5.300Probable Ras-related protein Rab7; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (205 aa)
NCU06176Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (187 aa)
NCU02409Uncharacterized protein. (892 aa)
NCU05796Trafficking protein particle complex subunit BET3. (193 aa)
pod-2Polarity defective-2. (508 aa)
NCU06624Chloride channel protein. (910 aa)
NCU05195Uncharacterized protein. (484 aa)
NCU01854Uncharacterized protein. (214 aa)
NCU03063Uncharacterized protein. (702 aa)
NCU03122Beclin 1, variant. (534 aa)
NCU02978Cytoskeleton assembly control protein SLA1p. (1168 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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