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vma-2 vma-2 vma-1 vma-1 vma-8 vma-8 NCU01539 NCU01539 NCU11370 NCU11370 NCU11307 NCU11307 NCU10477 NCU10477 NCU00916 NCU00916 NCU01668 NCU01668 NCU06366 NCU06366 NCU07401 NCU07401 NCU05166 NCU05166 tcu-2 tcu-2 NCU03122 NCU03122 NCU16725 NCU16725 NCU08961 NCU08961 cax cax NCU06073 NCU06073 NCU02409 NCU02409 NCU00376 NCU00376 NCU00091 NCU00091 NCU08997 NCU08997 cdc42 cdc42 vma-11 vma-11 vma-7 vma-7 epp-1 epp-1 mch1 mch1 17E5.300 17E5.300 ssh4 ssh4 apg-10 apg-10 apg-6 apg-6 apg-13 apg-13 NCU00621 NCU00621 dapB dapB NCU03029 NCU03029 NCU03221 NCU03221 NCU08056 NCU08056 NCU08066 NCU08066 NCU08095 NCU08095 NCU00975 NCU00975 NCU02725 NCU02725 vma-13 vma-13 apg-14 apg-14 apg-11 apg-11 NCU03105 NCU03105 NCU00795 NCU00795 NCU08609 NCU08609 NCU08618 NCU08618 NCU02083 NCU02083 vma-16 vma-16 NCU03145 NCU03145 NCU00753 NCU00753 NCU02100 NCU02100 NCU02112 NCU02112 NCU02113 NCU02113 NCU08110 NCU08110 cln3 cln3 NCU05422 NCU05422 NCU06231 NCU06231 NCU07816 NCU07816 NCU06268 NCU06268 NCU06284 NCU06284 NCU07337 NCU07337 vma-9 vma-9 NCU07707 NCU07707 NCU07709 NCU07709 iml1 iml1 NCU07711 NCU07711 NCU08689 NCU08689 NCU04100 NCU04100 ptr-3 ptr-3 NCU05591 NCU05591 NCU07061 NCU07061 NCU05775 NCU05775 NCU02259 NCU02259 NCU06043 NCU06043 NCU05902 NCU05902 NCU04125 NCU04125 NCU03605 NCU03605 NCU01202 NCU01202 NCU01099 NCU01099 NCU05360 NCU05360 NCU06773 NCU06773 NCU02026 NCU02026 rac-1 rac-1 NCU04355 NCU04355 NCU04541 NCU04541 NCU04090 NCU04090 apg-1 apg-1 NCU05060 NCU05060 NCU03883 NCU03883 NCU01481 NCU01481 vac8 vac8 NCU00453 NCU00453 NCU00029 NCU00029 NCU00356 NCU00356 gpr-5 gpr-5 NCU00242 NCU00242 apg-8 apg-8 NCU10009 NCU10009 gh38-1 gh38-1 mig-12 mig-12 NCU05959 NCU05959 vma-5 vma-5 NCU07387 NCU07387 NCU09121 NCU09121 vad-6 vad-6 9G6.250 9G6.250 NCU04160 NCU04160 NCU04188 NCU04188 NCU03783 NCU03783 NCU03784 NCU03784 NCU04281 NCU04281 pho-2 pho-2 NCU04165 NCU04165 nca-2 nca-2 NCU04598 NCU04598 NCU01745 NCU01745 nca-3 nca-3 vph-1 vph-1 vma-4 vma-4 vma-10 vma-10 vma-6 vma-6 vma-3 vma-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
vma-2V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family. (513 aa)
vma-1V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (607 aa)
vma-8V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. V- ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system; Belongs to the V-ATPase D subunit family. (264 aa)
NCU01539Vacuolar morphogenesis protein AvaB. (1138 aa)
NCU113706-phosphogluconate dehydrogenase 2. (306 aa)
NCU11307CCC1. (307 aa)
NCU10477Ubiquitin-conjugating enzyme E2. (156 aa)
NCU00916Membrane bound cation transporter; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (794 aa)
NCU01668Uncharacterized protein. (871 aa)
NCU06366Vacuolar calcium ion transporter; Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (504 aa)
NCU07401DUF202 domain-containing protein. (313 aa)
NCU05166Uncharacterized protein. (243 aa)
tcu-2TCU-2. (200 aa)
NCU03122Beclin 1, variant. (534 aa)
NCU16725Potassium ion channel Yvc1. (653 aa)
NCU08961Uncharacterized protein. (1047 aa)
caxVacuolar calcium ion transporter; Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (507 aa)
NCU06073Uncharacterized protein. (725 aa)
NCU02409Uncharacterized protein. (892 aa)
NCU00376GTR/RAG family GTPase Gtr2. (427 aa)
NCU00091Zinc_ribbon_16 domain-containing protein. (1196 aa)
NCU08997Alkaline phosphatase. (587 aa)
cdc42Rho-type GTPase. (196 aa)
vma-11V-type proton ATPase 16 kDa proteolipid subunit 2; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). (167 aa)
vma-7V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). (124 aa)
epp-1Endopolyphosphatase; Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths. (731 aa)
mch1Probable transporter mch1; Probable transporter; Belongs to the major facilitator superfamily. (598 aa)
17E5.300Probable Ras-related protein Rab7; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (205 aa)
ssh4Protein ssh4; Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity); Belongs to the SSH4 family. (503 aa)
apg-10Autophagy-related protein 18; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation- induced autophagy. Involved in correct apg-7/atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). (436 aa)
apg-6Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With cpr-1/atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also in [...] (121 aa)
apg-13Vacuolar fusion protein mon1; Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis; Belongs to the MON1/SAND family. (678 aa)
NCU00621TORC1 growth control complex subunit Kog1. (1473 aa)
dapBProbable dipeptidyl-aminopeptidase B; Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N- termini provided that the penultimate residue is proline. (924 aa)
NCU03029Uncharacterized protein. (623 aa)
NCU03221PX domain-containing protein. (274 aa)
NCU08056ABC drug exporter AtrF; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1612 aa)
NCU08066Amino acid transporter. (549 aa)
NCU08095Uncharacterized protein. (245 aa)
NCU00975Uncharacterized protein. (331 aa)
NCU02725Uncharacterized protein. (984 aa)
vma-13V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (481 aa)
apg-14SVP1-like protein 2; Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways. (429 aa)
apg-11Autophagy-related protein 22; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity); Belongs to the ATG22 family. (737 aa)
NCU03105Uncharacterized protein. (545 aa)
NCU00795Membrane bound cation transporter; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (575 aa)
NCU08609Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family. (345 aa)
NCU08618ADP-ribosylation factor family protein; Belongs to the small GTPase superfamily. Arf family. (183 aa)
NCU020831-phosphatidylinositol-3-phosphate 5-kinase. (2558 aa)
vma-16Vacuolar ATPase proteolipid subunit; Belongs to the V-ATPase proteolipid subunit family. (200 aa)
NCU03145Oxidative stress resistance. (522 aa)
NCU00753Uncharacterized protein. (444 aa)
NCU02100Probable lysosomal cobalamin transporter; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity); Belongs to the LIMR family. LMBRD1 subfamily. (603 aa)
NCU02112Uncharacterized protein. (1808 aa)
NCU02113Ubiquitin-conjugating enzyme E2 13; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
NCU08110Vacuolar transporter chaperone 4. (771 aa)
cln3Protein btn-1; Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis (By similarity); Belongs to the battenin family. (464 aa)
NCU05422E3 ubiquitin-protein ligase PEP5. (1016 aa)
NCU06231Vacuolar amino acid transporter 1. (688 aa)
NCU07816Magnesium and cobalt transporter CorA. (650 aa)
NCU06268Probable vacuolar protein sorting-associated protein 16 homolog; Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. (865 aa)
NCU06284Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (881 aa)
NCU07337Uncharacterized protein. (141 aa)
vma-9Vacuolar ATPase subunit E. (75 aa)
NCU07707FNIP_N domain-containing protein. (1229 aa)
NCU07709Cation efflux system protein czcD. (326 aa)
iml1Vacuolar membrane-associated protein iml1. (2004 aa)
NCU07711Vacuolar calcium ion transporter/H(+) exchanger; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (594 aa)
NCU08689Polyphosphoinositide phosphatase Fig4. (1190 aa)
NCU04100Vacuolar sorting protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (706 aa)
ptr-3Palmitoyltransferase pfa3; Palmitoyltransferase specific for vac8. Palmitoylates vac8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity). (622 aa)
NCU05591ABC transporter CDR4; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1547 aa)
NCU07061Uncharacterized protein. (177 aa)
NCU05775Amino acid transporter. (620 aa)
NCU02259UDENN FLCN/SMCR8-type domain-containing protein. (523 aa)
NCU06043GPR/FUN34 family protein. (303 aa)
NCU05902Vacuolar assembly protein. (1359 aa)
NCU04125TGF beta receptor associated protein 1. (1266 aa)
NCU03605Amidohydrolase. (453 aa)
NCU01202Uncharacterized protein. (274 aa)
NCU01099GTP-binding protein GTR1. (409 aa)
NCU05360Calcium permease; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1146 aa)
NCU06773Uncharacterized protein. (462 aa)
NCU02026Uncharacterized protein. (678 aa)
rac-1Small GTPase RAC. (200 aa)
NCU04355Phosphatidylinositol 4-kinase type II subunit alpha. (867 aa)
NCU04541SNF7 family protein. (218 aa)
NCU04090Niemann-Pick C1 protein. (1279 aa)
apg-1Serine/threonine-protein kinase apg-1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventin [...] (968 aa)
NCU05060CFEM domain-containing protein. (468 aa)
NCU03883Vacuolar transporter chaperone 1. (127 aa)
NCU01481Amino acid transporter. (643 aa)
vac8Vacuolar protein 8; Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole; Belongs to the beta-catenin family. (559 aa)
NCU00453Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (663 aa)
NCU00029ZIP metal ion transporter. (514 aa)
NCU00356Nucleoside transporter. (524 aa)
gpr-5PQ loop repeat protein. (538 aa)
NCU00242V-SNARE. (562 aa)
apg-8Autophagy-related protein 11; Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity). (1429 aa)
NCU10009ATP-binding cassette transporter; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1478 aa)
gh38-1Alpha-mannosidase. (1089 aa)
mig-12ABC multidrug transporter; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1405 aa)
NCU05959Vesicle transport V-SNARE protein VTI1. (228 aa)
vma-5V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (391 aa)
NCU07387RING-type domain-containing protein. (547 aa)
NCU09121Vacuolar sorting protein; Belongs to the STXBP/unc-18/SEC1 family. (666 aa)
vad-6Nitrate assimilation regulatory protein nirA. (862 aa)
9G6.250Vacuolar membrane protease; May be involved in vacuolar sorting and osmoregulation. (1072 aa)
NCU04160Uncharacterized protein. (360 aa)
NCU04188UPF0220 domain-containing protein. (173 aa)
NCU03783Transmembrane domain transporter. (772 aa)
NCU03784Cation chloride cotransporter. (1247 aa)
NCU04281WD-repeat protein pop3. (318 aa)
pho-2Alkaline phosphatase; Belongs to the alkaline phosphatase family. (668 aa)
NCU04165Low-temperature viability protein ltv1. (417 aa)
nca-2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1449 aa)
NCU04598Uncharacterized protein. (1136 aa)
NCU01745SPX domain-containing protein. (800 aa)
nca-3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1152 aa)
vph-1V-type proton ATPase subunit a; Subunit of the integral membrane V0 complex of vacuolar ATPase essential for assembly and catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). (856 aa)
vma-4V-type proton ATPase subunit E; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (230 aa)
vma-10V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (115 aa)
vma-6V-type proton ATPase subunit d; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. (364 aa)
vma-3V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (161 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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