STRINGSTRING
NCU00337 NCU00337 NCU04378 NCU04378 NCU04548 NCU04548 NCU06481 NCU06481 NCU00081 NCU00081 drc-4 drc-4 NCU02232 NCU02232 msh6 msh6 NCU09793 NCU09793 NCU04738 NCU04738 NCU05607 NCU05607 rpa-2 rpa-2 NCU05194 NCU05194 NCU06623 NCU06623 NCU06371 NCU06371 NCU08317 NCU08317 pcn pcn NCU09261 NCU09261 prd-4 prd-4 NCU02776 NCU02776 NCU03072 NCU03072 NCU03073 NCU03073 drc-1 drc-1 mph1 mph1 MCM7 MCM7 mus-59 mus-59 NCU06767 NCU06767 NCU07870 NCU07870 drc-3 drc-3 NCU07878 NCU07878 NCU08009 NCU08009 mus-51 mus-51 mei-3 mei-3 NCU08706 NCU08706 NCU06710 NCU06710 NCU01370 NCU01370 NCU04327 NCU04327 mrc1 mrc1 NCU03763 NCU03763 NCU03629 NCU03629 rpa-1 rpa-1 NCU05458 NCU05458 NCU08427 NCU08427 NCU06856 NCU06856 NCU05433 NCU05433 mus-27 mus-27 NCU01171 NCU01171 pold-1 pold-1 NCU03597 NCU03597 NCU03714 NCU03714 NCU09240 NCU09240 NCU08700 NCU08700 NCU05271 NCU05271 NCU04749 NCU04749 NCU07519 NCU07519 mip-1 mip-1 B14D6.460 B14D6.460 5F3.150 5F3.150 NCU02539 NCU02539 csm-3 csm-3 npl4 npl4 NCU02683 NCU02683 NCU02687 NCU02687 cdc7 cdc7 NCU03426 NCU03426 cac-2 cac-2 clf-1 clf-1 NCU10376 NCU10376 ctc-1 ctc-1 NCU03564 NCU03564 NCU09706 NCU09706 NCU10467 NCU10467 NCU05945 NCU05945 tof-1 tof-1 NCU05986 NCU05986 NCU09500 NCU09500 NCU09503 NCU09503 NCU10155 NCU10155
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU00337Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (676 aa)
NCU04378DNA replication initiation factor Cdc45. (874 aa)
NCU04548DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2259 aa)
NCU06481DNA ligase. (923 aa)
NCU00081DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (695 aa)
drc-4DNA replication regulator sld2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (610 aa)
NCU02232DNA primase; Belongs to the eukaryotic-type primase small subunit family. (576 aa)
msh6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1246 aa)
NCU09793DEAD/DEAH box DNA helicase. (1563 aa)
NCU04738Zf-primase domain-containing protein. (977 aa)
NCU05607DUF602 domain-containing protein. (313 aa)
rpa-2Replication protein A-2. (284 aa)
NCU05194DNA helicase; Belongs to the MCM family. (972 aa)
NCU06623CBFD_NFYB_HMF domain-containing protein. (304 aa)
NCU06371Mitochondrial ATP-dependent RNA helicase Suv3. (796 aa)
NCU08317PHD-type domain-containing protein. (1021 aa)
pcnProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
NCU09261DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (221 aa)
prd-4Serine/threonine-protein kinase chk2. (702 aa)
NCU02776Cell division control protein; Belongs to the CDC6/cdc18 family. (691 aa)
NCU03072SLD3 domain-containing protein. (1091 aa)
NCU03073CBFD_NFYB_HMF domain-containing protein. (397 aa)
drc-1DNA replication complex GINS protein psf1; The GINS complex plays an essential role in the initiation of DNA replication. (216 aa)
mph1ATP-dependent DNA helicase mph1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1168 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (824 aa)
mus-59Serine/threonine-protein kinase. (1233 aa)
NCU06767Replication factor C subunit 1. (1086 aa)
NCU07870DNA polymerase. (1479 aa)
drc-3DNA replication complex GINS protein psf3; The GINS complex plays an essential role in the initiation of DNA replication. (218 aa)
NCU07878RRM domain-containing protein. (356 aa)
NCU08009DNA helicase; Belongs to the MCM family. (944 aa)
mus-51ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (645 aa)
mei-3DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (353 aa)
NCU08706AAA family ATPase. (622 aa)
NCU06710ClpTM1 domain-containing protein. (657 aa)
NCU01370Uncharacterized protein. (603 aa)
NCU04327DNA helicase; Belongs to the MCM family. (882 aa)
mrc1MRC1. (1464 aa)
NCU03763DNA polymerase delta subunit 2. (525 aa)
NCU03629Uncharacterized protein. (112 aa)
rpa-1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
NCU05458Uncharacterized protein. (2319 aa)
NCU08427Activator 1 subunit 3. (389 aa)
NCU06856Ubiquitin fusion degradation protein. (382 aa)
NCU05433Uncharacterized protein. (412 aa)
mus-27Chromosome segregation protein. (879 aa)
NCU01171DNA helicase; Belongs to the MCM family. (724 aa)
pold-1DNA polymerase. (1104 aa)
NCU03597DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (667 aa)
NCU03714Thioredoxin. (580 aa)
NCU09240Vezatin domain-containing protein. (658 aa)
NCU08700Uncharacterized protein. (1043 aa)
NCU05271Uncharacterized protein. (1316 aa)
NCU04749DNA replication helicase Dna2. (1727 aa)
NCU07519ATP-dependent DNA helicase; Belongs to the helicase family. (813 aa)
mip-1DNA polymerase gamma, mitochondrial; Involved in the replication of mitochondrial DNA. (1456 aa)
B14D6.460Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. (352 aa)
5F3.150Probable DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (513 aa)
NCU02539DNA helicase; Belongs to the MCM family. (1013 aa)
csm-3Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with tof-1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (409 aa)
npl4Nuclear protein localization protein 4; Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity); Belongs to the NPL4 family. (660 aa)
NCU02683Uncharacterized protein. (738 aa)
NCU02687Activator 1 41 kDa subunit. (387 aa)
cdc7Cell cycle protein kinase. (526 aa)
NCU03426Pps1 dual specificty phosphatase. (712 aa)
cac-2Chromatin assembly factor 1 protein. (732 aa)
clf-1Pre-mRNA-splicing factor clf-1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (695 aa)
NCU10376Uncharacterized protein. (441 aa)
ctc-1FACT complex subunit ctc-1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (565 aa)
NCU03564Flap structure-specific endonuclease. (1037 aa)
NCU09706DNA ligase. (917 aa)
NCU10467Replication factor C subunit 4. (357 aa)
NCU05945Uncharacterized protein. (408 aa)
tof-1Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with csm-3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1235 aa)
NCU05986Sucrase/ferredoxin domain-containing protein. (381 aa)
NCU09500ATPase_AAA_core domain-containing protein. (1353 aa)
NCU09503Uncharacterized protein. (1048 aa)
NCU10155DNA polymerase epsilon subunit B. (851 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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