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| | NCU01534 | PAPA-1 domain-containing protein. (430 aa) |
| | NCU01961 | DNA lyase Apn2. (655 aa) |
| | vad-2 | VAD-2. (734 aa) |
| | NCU16891 | Uncharacterized protein. (294 aa) |
| | bdp-3 | Bromodomain protein-3, variant. (1102 aa) |
| | NCU16387 | XPGI domain-containing protein. (226 aa) |
| | ck-1a | Casein kinase I isoform delta; Belongs to the protein kinase superfamily. (384 aa) |
| | NCU10788 | Uncharacterized protein. (386 aa) |
| | NCU09240 | Vezatin domain-containing protein. (658 aa) |
| | NCU16423 | Uncharacterized protein. (378 aa) |
| | NCU16422 | Uncharacterized protein. (79 aa) |
| | rpa-3 | Replication protein A-3. (108 aa) |
| | mus-9 | Phosphatidyl inositol 3-kinase; Belongs to the PI3/PI4-kinase family. (2492 aa) |
| | NCU11219 | A/G-specific adenine glycosylase. (851 aa) |
| | NCU11220 | A/G-specific adenine glycosylase. (678 aa) |
| | dnr-8 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (394 aa) |
| | NCU10467 | Replication factor C subunit 4. (357 aa) |
| | NCU10477 | Ubiquitin-conjugating enzyme E2. (156 aa) |
| | NCU11357 | Cell cycle control protein. (478 aa) |
| | cdc7 | Cell cycle protein kinase. (526 aa) |
| | NCU01771 | DNA repair protein rhp57. (510 aa) |
| | NCU06788 | Chromo domain-containing protein. (145 aa) |
| | msh-2 | DNA mismatch repair protein msh-2; Involved in post-replicative DNA-mismatch repair. Binds to mismatch-containing DNA (By similarity). (937 aa) |
| | phr | Deoxyribodipyrimidine photo-lyase; Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. (615 aa) |
| | uvs-2 | Postreplication repair E3 ubiquitin-protein ligase rad18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme mus-8/ubc2 to form the mus-8/ubc2-uvs-2/rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. (501 aa) |
| | mus-8 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa) |
| | mus-18 | UV-damage endonuclease; Endonuclease for the repair of UV-irradiated DNA. Involved in the excision of cyclobutane pyrimidine dimers (CPD) and 6-4 pyrimidine pyrimidones (6-4PP) which forms the UV damage repair (UVDR) pathway; Belongs to the uve1/UvsE family. (656 aa) |
| | NCU01580 | Transcription factor TFIIH subunit Tfb4. (439 aa) |
| | NCU01569 | WD repeat containing protein 48. (1027 aa) |
| | NCU01793 | RNA binding domain-containing protein. (249 aa) |
| | NCU01831 | General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (469 aa) |
| | NCU03528 | DNA polymerase delta subunit 4. (241 aa) |
| | NCU03924 | DNA repair protein Rtt107. (847 aa) |
| | NTH1 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (835 aa) |
| | NCU01365 | ATP dependent DNA ligase domain-containing protein. (1072 aa) |
| | NCU03652 | SNF2 family helicase/ATPase. (1548 aa) |
| | NCU08938 | DNA-3-methyladenine glycosylase. (468 aa) |
| | NCU01410 | DUF1711 domain-containing protein. (291 aa) |
| | NCU04327 | DNA helicase; Belongs to the MCM family. (882 aa) |
| | spo11 | Meiosis-specific topoisomerase Spo11. (466 aa) |
| | rad16 | DNA repair protein RAD16. (1079 aa) |
| | NCU03649 | Uncharacterized protein. (608 aa) |
| | NCU03629 | Uncharacterized protein. (112 aa) |
| | rpa-1 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa) |
| | NCU01340 | Uncharacterized protein. (215 aa) |
| | NCU01321 | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (602 aa) |
| | pold-1 | DNA polymerase. (1104 aa) |
| | NCU01171 | DNA helicase; Belongs to the MCM family. (724 aa) |
| | gh61-4 | Endoglucanase II. (238 aa) |
| | mus-26 | MUS26. (299 aa) |
| | mus-27 | Chromosome segregation protein. (879 aa) |
| | NCU05385 | MutL_C domain-containing protein. (937 aa) |
| | NCU05363 | 26S protease regulatory subunit 8; Belongs to the AAA ATPase family. (389 aa) |
| | NCU06782 | Zinc metalloproteinase. (404 aa) |
| | upr-1 | DNA polymerase. (1938 aa) |
| | mei-3 | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (353 aa) |
| | NCU00424 | Spo76 protein. (1595 aa) |
| | mus-25 | DNA repair and recombination protein RAD54. (835 aa) |
| | pp4 | Serine/threonine-protein phosphatase. (423 aa) |
| | uvs-6 | UVS6. (1314 aa) |
| | mus-38 | MUS38. (960 aa) |
| | NCU04548 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2259 aa) |
| | NCU03564 | Flap structure-specific endonuclease. (1037 aa) |
| | ctc-1 | FACT complex subunit ctc-1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (565 aa) |
| | NCU00081 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (695 aa) |
| | mus-52 | ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (725 aa) |
| | NCU00185 | BRCT domain-containing protein. (382 aa) |
| | NCU01625 | DNA repair helicase RAD3. (806 aa) |
| | NCU03885 | Uncharacterized protein. (680 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (931 aa) |
| | crf3-1 | SNF2-family ATP dependent chromatin remodeling factor snf21. (1482 aa) |
| | NCU06481 | DNA ligase. (923 aa) |
| | hat-1 | Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (508 aa) |
| | NCU06438 | DNA repair helicase RAD25. (862 aa) |
| | NCU04378 | DNA replication initiation factor Cdc45. (874 aa) |
| | NCU03968 | SP-RING-type domain-containing protein. (404 aa) |
| | NCU03956 | Plus3 domain-containing protein. (601 aa) |
| | yaf9 | Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (309 aa) |
| | mus-21 | Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2939 aa) |
| | cul-4 | Ubiquitin ligase subunit CulD; Belongs to the cullin family. (1039 aa) |
| | NCU10077 | SAE2 domain-containing protein. (604 aa) |
| | nhp-1 | Non-histone chromosomal protein 6; DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity). (103 aa) |
| | NCU10044 | AP_endonuc_2 domain-containing protein. (516 aa) |
| | NCU07411 | DNA-directed DNA polymerase theta. (999 aa) |
| | NCU07410 | BTB domain-containing protein. (692 aa) |
| | msh1 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1249 aa) |
| | NCU10155 | DNA polymerase epsilon subunit B. (851 aa) |
| | NCU09500 | ATPase_AAA_core domain-containing protein. (1353 aa) |
| | mus-41 | DNA repair protein rad5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein uvs-2/rad18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1228 aa) |
| | NCU05966 | DNA repair protein. (603 aa) |
| | NCU09439 | RecQ mediated genome instability protein Rmi1. (284 aa) |
| | NCU07568 | HMG box domain-containing protein. (353 aa) |
| | NCU05984 | Formamidopyrimidine-DNA glycosylase. (415 aa) |
| | tof-1 | Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with csm-3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1235 aa) |
| | NCU08883 | SNF2_N domain-containing protein. (355 aa) |
| | NCU07381 | DNA cross-link repair protein pso2/snm1. (1031 aa) |
| | rpt-4 | Proteasome 26S subunit; Belongs to the AAA ATPase family. (390 aa) |
| | NCU09706 | DNA ligase. (917 aa) |
| | rad23 | Rad23-like protein. (383 aa) |
| | nst-4 | Hst3p. (1327 aa) |
| | NCU09226 | WLM domain-containing protein. (508 aa) |
| | tca-14 | Fumarate hydratase. (533 aa) |
| | drc-4 | DNA replication regulator sld2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (610 aa) |
| | gh61-1 | Endoglucanase II. (322 aa) |
| | NCU06089 | Exonuclease. (758 aa) |
| | NCU08151 | DNA kinase/phosphatase Pnk1. (524 aa) |
| | msh6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1246 aa) |
| | NCU02402 | SMC_N domain-containing protein. (1167 aa) |
| | col-25 | Fungal specific transcription factor. (1194 aa) |
| | NCU06049 | DNA damage response protein RcaA. (912 aa) |
| | NCU09779 | Oxidoreductase. (358 aa) |
| | mus-44 | Mating-type switching protein swi10. (405 aa) |
| | mus-50 | UvrD/REP helicase. (1105 aa) |
| | NCU04786 | SNF2 family helicase/ATPase. (1197 aa) |
| | NCU05523 | RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (501 aa) |
| | NCU05517 | Mitochondrial genome maintenance protein MGM101. (337 aa) |
| | epl-1 | Enhancer of polycomb-like protein 1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity). (589 aa) |
| | stk-18 | Histone acetylase complex subunit Paf400; Belongs to the PI3/PI4-kinase family. (3895 aa) |
| | parp | Poly [ADP-ribose] polymerase. (670 aa) |
| | NCU06572 | zf-C2HE domain-containing protein. (299 aa) |
| | NCU07893 | RSC complex subunit Sfh1. (591 aa) |
| | NCU07891 | Endo/exonuclease/phosphatase domain-containing protein. (446 aa) |
| | NCU05253 | XPG_I_2 domain-containing protein. (574 aa) |
| | NCU05250 | Sister chromatid cohesion protein. (1955 aa) |
| | NCU05281 | Uncharacterized protein. (298 aa) |
| | NCU06585 | Rad4 family protein. (1040 aa) |
| | rpa-2 | Replication protein A-2. (284 aa) |
| | bdp-1 | Bromodomain protein-1. (480 aa) |
| | NCU08806 | RECA_2 domain-containing protein. (442 aa) |
| | NCU05307 | Uncharacterized protein. (602 aa) |
| | NCU07282 | CUE domain-containing protein. (964 aa) |
| | esa-1 | Histone acetyltransferase esa-1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recr [...] (506 aa) |
| | NCU05194 | DNA helicase; Belongs to the MCM family. (972 aa) |
| | NCU06547 | Uncharacterized protein. (624 aa) |
| | NCU07663 | GRF zinc finger domain-containing protein. (510 aa) |
| | dim-8 | DNA damage-binding protein 1. (1158 aa) |
| | NCU06365 | DEAD/DEAH box helicase. (1175 aa) |
| | NCU06345 | Tyrosyl-DNA phosphodiesterase. (661 aa) |
| | sem-1 | Putative 26S proteasome complex subunit sem-1; Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis; Belongs to the DSS1/SEM1 family. (91 aa) |
| | mus-51 | ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (645 aa) |
| | drc-2 | DNA replication complex GINS protein psf2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (273 aa) |
| | NCU06992 | DNA repair protein Nse1. (342 aa) |
| | pms-1 | DNA mismatch repair protein. (1157 aa) |
| | NCU08009 | DNA helicase; Belongs to the MCM family. (944 aa) |
| | NCU07998 | Uncharacterized protein. (441 aa) |
| | NCU07878 | RRM domain-containing protein. (356 aa) |
| | mus-53 | DNA ligase 4; Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining; Belongs to the ATP-dependent DNA ligase family. (1050 aa) |
| | dot-1 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (531 aa) |
| | csb | DNA repair protein Rhp26/Rad26. (1173 aa) |
| | atrx | ATRX. (1869 aa) |
| | NCU08553 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (130 aa) |
| | arp-8 | Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (748 aa) |
| | NCU06222 | Tyrosyl-DNA phosphodiesterase domain-containing protein. (691 aa) |
| | NCU07870 | DNA polymerase. (1479 aa) |
| | eaf-1 | Chromatin modification-related protein eaf-1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (2189 aa) |
| | NCU09494 | Uncharacterized protein. (593 aa) |
| | NCU06767 | Replication factor C subunit 1. (1086 aa) |
| | poli | DNA polymerase Tau. (660 aa) |
| | mus-43 | DNA repair protein rad14. (435 aa) |
| | nst-3 | SIR2 family histone deacetylase. (647 aa) |
| | mlh-2 | MUTL-2. (772 aa) |
| | mbp3 | Methylated-DNA-binding protein3. (631 aa) |
| | NCU09065 | SMC_N domain-containing protein. (1138 aa) |
| | NCU09384 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (872 aa) |
| | mus-59 | Serine/threonine-protein kinase. (1233 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (824 aa) |
| | msh-3 | DNA mismatch repair protein msh-3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh-2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh-3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bi [...] (1145 aa) |
| | NCU07461 | DNA polymerase POL4. (846 aa) |
| | mus-81 | Crossover junction endonuclease mus-81; Interacts with eme-1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (645 aa) |
| | NCU02098 | G/U mismatch-specific DNA glycosylase. (396 aa) |
| | mus-42 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1347 aa) |
| | mph1 | ATP-dependent DNA helicase mph1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1168 aa) |
| | NCU03040 | N-glycosylase/DNA lyase. (449 aa) |
| | NCU03036 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (885 aa) |
| | drc-1 | DNA replication complex GINS protein psf1; The GINS complex plays an essential role in the initiation of DNA replication. (216 aa) |
| | NCU02113 | Ubiquitin-conjugating enzyme E2 13; Belongs to the ubiquitin-conjugating enzyme family. (151 aa) |
| | polh | Sister chromatid cohesion protein Eso1. (672 aa) |
| | NCU03291 | Double-strand-break repair protein rad21. (658 aa) |
| | eaf6 | Chromatin modification-related protein eaf6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (187 aa) |
| | NCU03280 | NUDIX domain-containing protein. (427 aa) |
| | NCU02187 | Uncharacterized protein. (291 aa) |
| | NCU00517 | Cell cycle checkpoint protein RAD17. (944 aa) |
| | NCU00832 | Uncharacterized protein. (402 aa) |
| | pcn | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa) |
| | NCU00880 | Phospholipase A-2-activating protein. (809 aa) |
| | slx4 | Structure-specific endonuclease subunit slx4; Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (1013 aa) |
| | NCU02001 | MAGE domain-containing protein. (334 aa) |
| | NCU03101 | Uncharacterized protein. (716 aa) |
| | mus-40 | DNA excision repair protein Rad2. (1269 aa) |
| | UNG1 | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (449 aa) |
| | NCU00964 | Uncharacterized protein. (1164 aa) |
| | NCU03190 | Rec8. (763 aa) |
| | NCU02687 | Activator 1 41 kDa subunit. (387 aa) |
| | csm-3 | Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with tof-1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (409 aa) |
| | NCU02587 | RNA polymerase II transcription factor B subunit 3. (362 aa) |
| | arp-4 | Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosome [...] (469 aa) |
| | NCU02539 | DNA helicase; Belongs to the MCM family. (1013 aa) |
| | NCU00657 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (431 aa) |
| | crf9-1 | RING-13 protein. (1214 aa) |
| | cry | Putative cryptochrome DASH, mitochondrial; May have a photoreceptor function; Belongs to the DNA photolyase class-1 family. (745 aa) |
| | crc-1 | SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (733 aa) |
| | crf2-1 | Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1997 aa) |
| | hel-2 | RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (481 aa) |
| | 5F3.150 | Probable DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (513 aa) |
| | hel-1 | RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa) |
| | B14D6.460 | Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. (352 aa) |
| | rtf-1 | General transcription and DNA repair factor IIH subunit rtf-1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has b [...] (72 aa) |
| | ctc-2 | FACT complex subunit ctc-2; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1032 aa) |
| | hh2a | Histone H2A; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (134 aa) |
| | mus-23 | Double-strand break repair protein mus-23; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity); Belongs to the MRE11/RAD32 family. (739 aa) |
| | mus-11 | DNA repair and recombination protein mus-11; Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the mei-3/rad51 recombinase (By similarity). (600 aa) |
| | tcf-29 | General transcription and DNA repair factor IIH subunit tcf-29; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has [...] (663 aa) |
| | rnh-201 | Ribonuclease H2 subunit A; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication. (317 aa) |
| | slx1 | Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (402 aa) |
| | NCU00470 | DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (484 aa) |
| | NCU00401 | Uncharacterized protein. (458 aa) |
| | NCU07519 | ATP-dependent DNA helicase; Belongs to the helicase family. (813 aa) |
| | NCU04749 | DNA replication helicase Dna2. (1727 aa) |
| | NCU02457 | DNA-directed polymerase kappa, variant. (646 aa) |
| | NCU03820 | Checkpoint protein; Belongs to the HUS1 family. (371 aa) |
| | NCU10417 | BRCT domain-containing protein. (297 aa) |
| | NCU12087 | Nitrilase. (897 aa) |
| | NCU16971 | Uncharacterized protein. (236 aa) |
| | NCU01145 | Uncharacterized protein. (205 aa) |
| | NCU05271 | Uncharacterized protein. (1316 aa) |
| | NCU05620 | Proteasome activator subunit 4, variant. (1955 aa) |
| | NCU12100 | Uncharacterized protein. (84 aa) |
| | NCU11088 | MGMT family protein, variant. (143 aa) |
| | mlh-1 | DNA mismatch repair protein mutL, variant. (751 aa) |
| | NCU08427 | Activator 1 subunit 3. (389 aa) |
| | NCU05458 | Uncharacterized protein. (2319 aa) |
| | NCU08706 | AAA family ATPase. (622 aa) |
| | NCU06787 | MRG domain-containing protein. (366 aa) |
