STRINGSTRING
NCU03956 NCU03956 mus-18 mus-18 NCU01580 NCU01580 NCU01793 NCU01793 NCU01831 NCU01831 NTH1 NTH1 NCU01365 NCU01365 rad16 rad16 NCU03649 NCU03649 rpa-1 rpa-1 pold-1 pold-1 NCU05363 NCU05363 mus-38 mus-38 NCU04548 NCU04548 NCU01625 NCU01625 NCU06481 NCU06481 NCU12087 NCU12087 NCU03820 NCU03820 tcf-29 tcf-29 rtf-1 rtf-1 NCU02587 NCU02587 mus-40 mus-40 NCU03040 NCU03040 mus-43 mus-43 NCU08553 NCU08553 csb csb mus-53 mus-53 NCU06365 NCU06365 NCU07282 NCU07282 rpa-2 rpa-2 NCU06585 NCU06585 NCU05523 NCU05523 mus-44 mus-44 rad23 rad23 rpt-4 rpt-4 cul-4 cul-4 NCU06438 NCU06438
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU03956Plus3 domain-containing protein. (601 aa)
mus-18UV-damage endonuclease; Endonuclease for the repair of UV-irradiated DNA. Involved in the excision of cyclobutane pyrimidine dimers (CPD) and 6-4 pyrimidine pyrimidones (6-4PP) which forms the UV damage repair (UVDR) pathway; Belongs to the uve1/UvsE family. (656 aa)
NCU01580Transcription factor TFIIH subunit Tfb4. (439 aa)
NCU01793RNA binding domain-containing protein. (249 aa)
NCU01831General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (469 aa)
NTH1Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (835 aa)
NCU01365ATP dependent DNA ligase domain-containing protein. (1072 aa)
rad16DNA repair protein RAD16. (1079 aa)
NCU03649Uncharacterized protein. (608 aa)
rpa-1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
pold-1DNA polymerase. (1104 aa)
NCU0536326S protease regulatory subunit 8; Belongs to the AAA ATPase family. (389 aa)
mus-38MUS38. (960 aa)
NCU04548DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2259 aa)
NCU01625DNA repair helicase RAD3. (806 aa)
NCU06481DNA ligase. (923 aa)
NCU12087Nitrilase. (897 aa)
NCU03820Checkpoint protein; Belongs to the HUS1 family. (371 aa)
tcf-29General transcription and DNA repair factor IIH subunit tcf-29; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has [...] (663 aa)
rtf-1General transcription and DNA repair factor IIH subunit rtf-1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has b [...] (72 aa)
NCU02587RNA polymerase II transcription factor B subunit 3. (362 aa)
mus-40DNA excision repair protein Rad2. (1269 aa)
NCU03040N-glycosylase/DNA lyase. (449 aa)
mus-43DNA repair protein rad14. (435 aa)
NCU08553DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (130 aa)
csbDNA repair protein Rhp26/Rad26. (1173 aa)
mus-53DNA ligase 4; Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining; Belongs to the ATP-dependent DNA ligase family. (1050 aa)
NCU06365DEAD/DEAH box helicase. (1175 aa)
NCU07282CUE domain-containing protein. (964 aa)
rpa-2Replication protein A-2. (284 aa)
NCU06585Rad4 family protein. (1040 aa)
NCU05523RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (501 aa)
mus-44Mating-type switching protein swi10. (405 aa)
rad23Rad23-like protein. (383 aa)
rpt-4Proteasome 26S subunit; Belongs to the AAA ATPase family. (390 aa)
cul-4Ubiquitin ligase subunit CulD; Belongs to the cullin family. (1039 aa)
NCU06438DNA repair helicase RAD25. (862 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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