STRINGSTRING
spo11 spo11 NCU16422 NCU16422 NCU16423 NCU16423 NCU10788 NCU10788 NCU16891 NCU16891 NCU16971 NCU16971 NCU03820 NCU03820 NCU00401 NCU00401 slx1 slx1 mus-11 mus-11 mus-23 mus-23 5F3.150 5F3.150 NCU02539 NCU02539 NCU03190 NCU03190 NCU03101 NCU03101 NCU02001 NCU02001 NCU03291 NCU03291 drc-1 drc-1 NCU03036 NCU03036 mph1 mph1 mus-81 mus-81 NCU07461 NCU07461 MCM7 MCM7 NCU09065 NCU09065 nst-3 nst-3 NCU06222 NCU06222 arp-8 arp-8 mus-53 mus-53 NCU07998 NCU07998 NCU08009 NCU08009 NCU06992 NCU06992 drc-2 drc-2 mus-51 mus-51 sem-1 sem-1 NCU05194 NCU05194 NCU08806 NCU08806 rpa-2 rpa-2 NCU05250 NCU05250 NCU07893 NCU07893 NCU06572 NCU06572 parp parp mus-44 mus-44 NCU06049 NCU06049 NCU02402 NCU02402 NCU06089 NCU06089 gh61-1 gh61-1 drc-4 drc-4 nst-4 nst-4 NCU09706 NCU09706 NCU07381 NCU07381 NCU09439 NCU09439 NCU05966 NCU05966 NCU07410 NCU07410 NCU07411 NCU07411 NCU03968 NCU03968 NCU04378 NCU04378 crf3-1 crf3-1 NCU03885 NCU03885 NCU00185 NCU00185 mus-52 mus-52 NCU03564 NCU03564 mus-38 mus-38 uvs-6 uvs-6 pp4 pp4 mus-25 mus-25 mei-3 mei-3 upr-1 upr-1 NCU05458 NCU05458 gh61-4 gh61-4 NCU01171 NCU01171 NCU01321 NCU01321 rpa-1 rpa-1 NCU04327 NCU04327 NCU01365 NCU01365 NCU01569 NCU01569 mus-8 mus-8 NCU01771 NCU01771 cdc7 cdc7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
spo11Meiosis-specific topoisomerase Spo11. (466 aa)
NCU16422Uncharacterized protein. (79 aa)
NCU16423Uncharacterized protein. (378 aa)
NCU10788Uncharacterized protein. (386 aa)
NCU16891Uncharacterized protein. (294 aa)
NCU16971Uncharacterized protein. (236 aa)
NCU03820Checkpoint protein; Belongs to the HUS1 family. (371 aa)
NCU00401Uncharacterized protein. (458 aa)
slx1Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (402 aa)
mus-11DNA repair and recombination protein mus-11; Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the mei-3/rad51 recombinase (By similarity). (600 aa)
mus-23Double-strand break repair protein mus-23; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity); Belongs to the MRE11/RAD32 family. (739 aa)
5F3.150Probable DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (513 aa)
NCU02539DNA helicase; Belongs to the MCM family. (1013 aa)
NCU03190Rec8. (763 aa)
NCU03101Uncharacterized protein. (716 aa)
NCU02001MAGE domain-containing protein. (334 aa)
NCU03291Double-strand-break repair protein rad21. (658 aa)
drc-1DNA replication complex GINS protein psf1; The GINS complex plays an essential role in the initiation of DNA replication. (216 aa)
NCU03036Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (885 aa)
mph1ATP-dependent DNA helicase mph1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1168 aa)
mus-81Crossover junction endonuclease mus-81; Interacts with eme-1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (645 aa)
NCU07461DNA polymerase POL4. (846 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (824 aa)
NCU09065SMC_N domain-containing protein. (1138 aa)
nst-3SIR2 family histone deacetylase. (647 aa)
NCU06222Tyrosyl-DNA phosphodiesterase domain-containing protein. (691 aa)
arp-8Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (748 aa)
mus-53DNA ligase 4; Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining; Belongs to the ATP-dependent DNA ligase family. (1050 aa)
NCU07998Uncharacterized protein. (441 aa)
NCU08009DNA helicase; Belongs to the MCM family. (944 aa)
NCU06992DNA repair protein Nse1. (342 aa)
drc-2DNA replication complex GINS protein psf2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (273 aa)
mus-51ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (645 aa)
sem-1Putative 26S proteasome complex subunit sem-1; Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis; Belongs to the DSS1/SEM1 family. (91 aa)
NCU05194DNA helicase; Belongs to the MCM family. (972 aa)
NCU08806RECA_2 domain-containing protein. (442 aa)
rpa-2Replication protein A-2. (284 aa)
NCU05250Sister chromatid cohesion protein. (1955 aa)
NCU07893RSC complex subunit Sfh1. (591 aa)
NCU06572zf-C2HE domain-containing protein. (299 aa)
parpPoly [ADP-ribose] polymerase. (670 aa)
mus-44Mating-type switching protein swi10. (405 aa)
NCU06049DNA damage response protein RcaA. (912 aa)
NCU02402SMC_N domain-containing protein. (1167 aa)
NCU06089Exonuclease. (758 aa)
gh61-1Endoglucanase II. (322 aa)
drc-4DNA replication regulator sld2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (610 aa)
nst-4Hst3p. (1327 aa)
NCU09706DNA ligase. (917 aa)
NCU07381DNA cross-link repair protein pso2/snm1. (1031 aa)
NCU09439RecQ mediated genome instability protein Rmi1. (284 aa)
NCU05966DNA repair protein. (603 aa)
NCU07410BTB domain-containing protein. (692 aa)
NCU07411DNA-directed DNA polymerase theta. (999 aa)
NCU03968SP-RING-type domain-containing protein. (404 aa)
NCU04378DNA replication initiation factor Cdc45. (874 aa)
crf3-1SNF2-family ATP dependent chromatin remodeling factor snf21. (1482 aa)
NCU03885Uncharacterized protein. (680 aa)
NCU00185BRCT domain-containing protein. (382 aa)
mus-52ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (725 aa)
NCU03564Flap structure-specific endonuclease. (1037 aa)
mus-38MUS38. (960 aa)
uvs-6UVS6. (1314 aa)
pp4Serine/threonine-protein phosphatase. (423 aa)
mus-25DNA repair and recombination protein RAD54. (835 aa)
mei-3DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (353 aa)
upr-1DNA polymerase. (1938 aa)
NCU05458Uncharacterized protein. (2319 aa)
gh61-4Endoglucanase II. (238 aa)
NCU01171DNA helicase; Belongs to the MCM family. (724 aa)
NCU01321DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (602 aa)
rpa-1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
NCU04327DNA helicase; Belongs to the MCM family. (882 aa)
NCU01365ATP dependent DNA ligase domain-containing protein. (1072 aa)
NCU01569WD repeat containing protein 48. (1027 aa)
mus-8Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
NCU01771DNA repair protein rhp57. (510 aa)
cdc7Cell cycle protein kinase. (526 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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