STRINGSTRING
NCU03291 NCU03291 rpa-3 rpa-3 msh4 msh4 cdc7 cdc7 NCU01771 NCU01771 msh-2 msh-2 mus-8 mus-8 NCU01569 NCU01569 NCU04665 NCU04665 NCU01365 NCU01365 NCU04327 NCU04327 spo11 spo11 NCU03629 NCU03629 rpa-1 rpa-1 NCU01340 NCU01340 NCU01171 NCU01171 gh61-4 gh61-4 NCU05458 NCU05458 upr-1 upr-1 mei-3 mei-3 bI1 bI1 NCU16009 NCU16009 NCU16010 NCU16010 NCU16011 NCU16011 NCU16019 NCU16019 NCU03765 NCU03765 NCU03517 NCU03517 mus-25 mus-25 pp4 pp4 uvs-6 uvs-6 mus-38 mus-38 NCU03564 NCU03564 NCU00081 NCU00081 mus-52 mus-52 NCU03885 NCU03885 PIF1 PIF1 NCU00030 NCU00030 NCU04459 NCU04459 NCU06481 NCU06481 NCU00103 NCU00103 NCU04378 NCU04378 NCU03968 NCU03968 NCU06935 NCU06935 NCU09855 NCU09855 NCU09500 NCU09500 NCU09439 NCU09439 NCU09706 NCU09706 nst-4 nst-4 drc-4 drc-4 gh61-1 gh61-1 NCU06089 NCU06089 NCU02402 NCU02402 NCU05756 NCU05756 NCU06049 NCU06049 NCU09793 NCU09793 mus-44 mus-44 NCU05517 NCU05517 gpe-1 gpe-1 NCU05250 NCU05250 rpa-2 rpa-2 NCU08806 NCU08806 NCU05194 NCU05194 sem-1 sem-1 mus-51 mus-51 drc-2 drc-2 crf5-1 crf5-1 NCU06992 NCU06992 NCU08039 NCU08039 NCU08009 NCU08009 NCU07998 NCU07998 mus-53 mus-53 nst-3 nst-3 NCU09065 NCU09065 NCU09384 NCU09384 MCM7 MCM7 msh-3 msh-3 mus-81 mus-81 mph1 mph1 qde-3 qde-3 NCU03036 NCU03036 drc-1 drc-1 NCU07442 NCU07442 cdc5 cdc5 slx4 slx4 NCU02001 NCU02001 cgi121 cgi121 NCU02539 NCU02539 NCU00657 NCU00657 mus-23 mus-23 mus-11 mus-11 slx1 slx1 NCU16705 NCU16705 NCU00401 NCU00401 NCU03820 NCU03820 NCU06338 NCU06338 NCU16971 NCU16971 NCU05271 NCU05271 NCU12100 NCU12100 mlh-1 mlh-1 NCU03337 NCU03337 NCU10788 NCU10788 NCU16423 NCU16423 NCU16422 NCU16422
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU03291Double-strand-break repair protein rad21. (658 aa)
rpa-3Replication protein A-3. (108 aa)
msh4MutS ortholog 4 protein. (1318 aa)
cdc7Cell cycle protein kinase. (526 aa)
NCU01771DNA repair protein rhp57. (510 aa)
msh-2DNA mismatch repair protein msh-2; Involved in post-replicative DNA-mismatch repair. Binds to mismatch-containing DNA (By similarity). (937 aa)
mus-8Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
NCU01569WD repeat containing protein 48. (1027 aa)
NCU04665Uncharacterized protein. (235 aa)
NCU01365ATP dependent DNA ligase domain-containing protein. (1072 aa)
NCU04327DNA helicase; Belongs to the MCM family. (882 aa)
spo11Meiosis-specific topoisomerase Spo11. (466 aa)
NCU03629Uncharacterized protein. (112 aa)
rpa-1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
NCU01340Uncharacterized protein. (215 aa)
NCU01171DNA helicase; Belongs to the MCM family. (724 aa)
gh61-4Endoglucanase II. (238 aa)
NCU05458Uncharacterized protein. (2319 aa)
upr-1DNA polymerase. (1938 aa)
mei-3DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (353 aa)
bI1Probable intron-encoded endonuclease bI1; Mitochondrial DNA endonuclease involved in intron homing. (448 aa)
NCU16009Probable intron-encoded endonuclease 2; Mitochondrial DNA endonuclease involved in intron homing. In the C-terminal section; belongs to the LAGLIDADG endonuclease family. (452 aa)
NCU16010Probable intron-encoded endonuclease 3; Mitochondrial DNA endonuclease involved in intron homing. In the C-terminal section; belongs to the LAGLIDADG endonuclease family. (533 aa)
NCU16011Probable intron-encoded endonuclease 4; Mitochondrial DNA endonuclease involved in intron homing. In the C-terminal section; belongs to the LAGLIDADG endonuclease family. (545 aa)
NCU16019Probable intron-encoded endonuclease 1; Mitochondrial DNA endonuclease involved in intron homing. (304 aa)
NCU037653'-5' exonuclease/helicase. (753 aa)
NCU03517Ski8. (342 aa)
mus-25DNA repair and recombination protein RAD54. (835 aa)
pp4Serine/threonine-protein phosphatase. (423 aa)
uvs-6UVS6. (1314 aa)
mus-38MUS38. (960 aa)
NCU03564Flap structure-specific endonuclease. (1037 aa)
NCU00081DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (695 aa)
mus-52ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (725 aa)
NCU03885Uncharacterized protein. (680 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (931 aa)
NCU00030Endonuclease. (332 aa)
NCU04459Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. (522 aa)
NCU06481DNA ligase. (923 aa)
NCU00103Uncharacterized protein. (292 aa)
NCU04378DNA replication initiation factor Cdc45. (874 aa)
NCU03968SP-RING-type domain-containing protein. (404 aa)
NCU06935Integrase_H2C2 domain-containing protein. (1347 aa)
NCU09855Nicotianamine synthase. (339 aa)
NCU09500ATPase_AAA_core domain-containing protein. (1353 aa)
NCU09439RecQ mediated genome instability protein Rmi1. (284 aa)
NCU09706DNA ligase. (917 aa)
nst-4Hst3p. (1327 aa)
drc-4DNA replication regulator sld2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (610 aa)
gh61-1Endoglucanase II. (322 aa)
NCU06089Exonuclease. (758 aa)
NCU02402SMC_N domain-containing protein. (1167 aa)
NCU05756Peptidase M4. (449 aa)
NCU06049DNA damage response protein RcaA. (912 aa)
NCU09793DEAD/DEAH box DNA helicase. (1563 aa)
mus-44Mating-type switching protein swi10. (405 aa)
NCU05517Mitochondrial genome maintenance protein MGM101. (337 aa)
gpe-1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (354 aa)
NCU05250Sister chromatid cohesion protein. (1955 aa)
rpa-2Replication protein A-2. (284 aa)
NCU08806RECA_2 domain-containing protein. (442 aa)
NCU05194DNA helicase; Belongs to the MCM family. (972 aa)
sem-1Putative 26S proteasome complex subunit sem-1; Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis; Belongs to the DSS1/SEM1 family. (91 aa)
mus-51ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (645 aa)
drc-2DNA replication complex GINS protein psf2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (273 aa)
crf5-1Chromatin remodeling factor 5-1. (907 aa)
NCU06992DNA repair protein Nse1. (342 aa)
NCU08039RING-type domain-containing protein. (359 aa)
NCU08009DNA helicase; Belongs to the MCM family. (944 aa)
NCU07998Uncharacterized protein. (441 aa)
mus-53DNA ligase 4; Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining; Belongs to the ATP-dependent DNA ligase family. (1050 aa)
nst-3SIR2 family histone deacetylase. (647 aa)
NCU09065SMC_N domain-containing protein. (1138 aa)
NCU09384DNA_MISMATCH_REPAIR_2 domain-containing protein. (872 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (824 aa)
msh-3DNA mismatch repair protein msh-3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh-2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh-3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bi [...] (1145 aa)
mus-81Crossover junction endonuclease mus-81; Interacts with eme-1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (645 aa)
mph1ATP-dependent DNA helicase mph1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1168 aa)
qde-3RecQ family helicase. (2330 aa)
NCU03036Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (885 aa)
drc-1DNA replication complex GINS protein psf1; The GINS complex plays an essential role in the initiation of DNA replication. (216 aa)
NCU07442Betaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (606 aa)
cdc5Serine/threonine protein kinase. (1021 aa)
slx4Structure-specific endonuclease subunit slx4; Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (1013 aa)
NCU02001MAGE domain-containing protein. (334 aa)
cgi121EKC/KEOPS complex subunit cgi121; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Cgi121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transc [...] (207 aa)
NCU02539DNA helicase; Belongs to the MCM family. (1013 aa)
NCU00657Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (431 aa)
mus-23Double-strand break repair protein mus-23; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity); Belongs to the MRE11/RAD32 family. (739 aa)
mus-11DNA repair and recombination protein mus-11; Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the mei-3/rad51 recombinase (By similarity). (600 aa)
slx1Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (402 aa)
NCU16705Chromo domain-containing protein. (145 aa)
NCU00401Uncharacterized protein. (458 aa)
NCU03820Checkpoint protein; Belongs to the HUS1 family. (371 aa)
NCU06338DNA topoisomerase 2. (1994 aa)
NCU16971Uncharacterized protein. (236 aa)
NCU05271Uncharacterized protein. (1316 aa)
NCU12100Uncharacterized protein. (84 aa)
mlh-1DNA mismatch repair protein mutL, variant. (751 aa)
NCU03337ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (483 aa)
NCU10788Uncharacterized protein. (386 aa)
NCU16423Uncharacterized protein. (378 aa)
NCU16422Uncharacterized protein. (79 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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