STRINGSTRING
NCU11402 NCU11402 NCU01763 NCU01763 NCU01539 NCU01539 NCU01646 NCU01646 ypt-1 ypt-1 Pkc Pkc NCU03543 NCU03543 NCU01745 NCU01745 NCU04610 NCU04610 NCU04598 NCU04598 NCU04125 NCU04125 NCU01100 NCU01100 NCU01049 NCU01049 NCU03947 NCU03947 NCU03258 NCU03258 apg-1 apg-1 NCU03883 NCU03883 vac8 vac8 NCU00411 NCU00411 atg15 atg15 apg-8 apg-8 atg12 atg12 NCU07574 NCU07574 apg-12 apg-12 NCU05959 NCU05959 NCU08989 NCU08989 vad-6 vad-6 cpr-1 cpr-1 NCU05902 NCU05902 apg-7 apg-7 NCU02268 NCU02268 NCU04840 NCU04840 NCU05160 NCU05160 NCU05234 NCU05234 mtp-2 mtp-2 NCU08676 NCU08676 NCU05213 NCU05213 stk-45 stk-45 NCU06174 NCU06174 vsp-6 vsp-6 NCU06212 NCU06212 NCU03246 NCU03246 NCU08110 NCU08110 apg-3 apg-3 NCU02779 NCU02779 NCU02024 NCU02024 NCU03126 NCU03126 NCU03105 NCU03105 apg-11 apg-11 apg-14 apg-14 vsp-5 vsp-5 NCU01878 NCU01878 NCU00674 NCU00674 NCU00673 NCU00673 NCU00656 NCU00656 apg-13 apg-13 apg-2 apg-2 apg-5 apg-5 vsp-3 vsp-3 apg-4 apg-4 apg-9 apg-9 apg-6 apg-6 apg-10 apg-10 sec16 sec16 NCU06267 NCU06267 NCU00018 NCU00018 NCU06073 NCU06073 NCU05796 NCU05796 NCU03122 NCU03122 NCU00579 NCU00579 NCU01668 NCU01668 NCU16445 NCU16445
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU11402DUF786 family protein. (130 aa)
NCU01763ACB domain-containing protein. (327 aa)
NCU01539Vacuolar morphogenesis protein AvaB. (1138 aa)
NCU01646Uncharacterized protein; Belongs to the CTL (choline transporter-like) family. (760 aa)
ypt-1GTP-binding protein ypt1; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Ypt-1 regulates the trafficking of secretory vesicles from the endoplasmic reticulum (ER) to the Golgi. Plays a role in the initial events of the autophagic vacuole development which take [...] (203 aa)
PkcProtein kinase C-like; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1142 aa)
NCU03543Uncharacterized protein. (382 aa)
NCU01745SPX domain-containing protein. (800 aa)
NCU04610Oxysterol binding protein. (986 aa)
NCU04598Uncharacterized protein. (1136 aa)
NCU04125TGF beta receptor associated protein 1. (1266 aa)
NCU01100Uncharacterized protein. (433 aa)
NCU01049Uncharacterized protein. (472 aa)
NCU03947E3 ubiquitin-protein ligase. (817 aa)
NCU03258Oxysterol-binding protein; Belongs to the OSBP family. (529 aa)
apg-1Serine/threonine-protein kinase apg-1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventin [...] (968 aa)
NCU03883Vacuolar transporter chaperone 1. (127 aa)
vac8Vacuolar protein 8; Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole; Belongs to the beta-catenin family. (559 aa)
NCU00411Uncharacterized protein. (190 aa)
atg15Putative lipase atg15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by atg15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (647 aa)
apg-8Autophagy-related protein 11; Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity). (1429 aa)
atg12Ubiquitin-like protein atg12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with apg-4/atg5 through a ubiquitin-like conjugating system involving also apg-5/atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-apg-4/atg5 conjugate functions as an E3-like enzyme which is required for lipidation of apg-6/atg8 and apg-6/atg8 association to the vesicle membranes (By similarity). (157 aa)
NCU07574Uncharacterized protein. (527 aa)
apg-12Sterol 3-beta-glucosyltransferase; Probable sterol 3-beta-glucosyltransferase that mediates autophagic degradation of peroxisomes (pexophagy) (By similarity). Also required for cytoplasm to vacuole transport (Cvt) and autophagic degradation of mitochondria (mitophagy) and nuclei (nucleophagy) (By similarity); Belongs to the glycosyltransferase 28 family. (1553 aa)
NCU05959Vesicle transport V-SNARE protein VTI1. (228 aa)
NCU08989ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (183 aa)
vad-6Nitrate assimilation regulatory protein nirA. (862 aa)
cpr-1Cysteine protease 1; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Cleaves the C-terminal amino acid of apg-6/atg8 to reveal a C-terminal glycine. Apg-6/atg8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to [...] (506 aa)
NCU05902Vacuolar assembly protein. (1359 aa)
apg-7Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machinerie [...] (908 aa)
NCU02268Uncharacterized protein. (816 aa)
NCU04840Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily. (1009 aa)
NCU05160ATP-dependent Zn protease. (486 aa)
NCU05234GTP-binding protein ryh1. (213 aa)
mtp-2Mitochondrial fission 1 protein; Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity). (153 aa)
NCU08676Uncharacterized protein. (222 aa)
NCU05213Uncharacterized protein. (910 aa)
stk-45Phosphoinositide 3-kinase regulatory subunit 4. (1563 aa)
NCU06174DUF1649 domain-containing protein. (271 aa)
vsp-6Sorting nexin-41; May be required for cytoplasm to vacuole transport (Cvt) and pexophagy. (619 aa)
NCU06212Trafficking protein particle complex subunit 6B. (262 aa)
NCU03246Tyrosine-protein phosphatase CDC14. (654 aa)
NCU08110Vacuolar transporter chaperone 4. (771 aa)
apg-3Autophagy-related protein 3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of apg-6/atg8. The atg12-apg-4/atg5 conjugate plays a role of an E3 and promotes the [...] (346 aa)
NCU02779Autophagy_act_C domain-containing protein. (258 aa)
NCU02024Atg29_N domain-containing protein. (516 aa)
NCU03126HMG box domain-containing protein. (314 aa)
NCU03105Uncharacterized protein. (545 aa)
apg-11Autophagy-related protein 22; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity); Belongs to the ATG22 family. (737 aa)
apg-14SVP1-like protein 2; Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways. (429 aa)
vsp-5Sorting nexin-4; Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans- Golgi network, for cytoplasm to vacuole transport (Cvt), mitophagy, and pexophagy (By similarity). (493 aa)
NCU01878Vesicle-mediated transporter. (1136 aa)
NCU00674Uncharacterized protein. (1002 aa)
NCU00673Serine protease p2; Belongs to the peptidase S8 family. (532 aa)
NCU00656Phosphatidylinositol 3-kinase VPS34. (914 aa)
apg-13Vacuolar fusion protein mon1; Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis; Belongs to the MON1/SAND family. (678 aa)
apg-2Autophagy-related protein 2; Required for cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes completion and peroxisome degradation. Belongs to the ATG2 family. (2051 aa)
apg-5Ubiquitin-like modifier-activating enzyme atg7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates atg12 for its conjugation with apg-4/atg5 and apg- 6/atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the apg-6/atg8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well [...] (699 aa)
vsp-3Vacuolar-sorting protein snf7; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH (By similarity). (228 aa)
apg-4Autophagy-related protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving apg-5/atg7 as an E1-like activating enzyme and at [...] (364 aa)
apg-9Autophagy-related protein 17; Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity); Belongs to the ATG17 family. (568 aa)
apg-6Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With cpr-1/atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also in [...] (121 aa)
apg-10Autophagy-related protein 18; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation- induced autophagy. Involved in correct apg-7/atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). (436 aa)
sec16COPII coat assembly protein sec16; Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity); Belongs to the SEC16 family. (2084 aa)
NCU06267Autophagy protein 16, variant. (232 aa)
NCU00018Cell division control protein Cdc48, variant; Belongs to the AAA ATPase family. (824 aa)
NCU06073Uncharacterized protein. (725 aa)
NCU05796Trafficking protein particle complex subunit BET3. (193 aa)
NCU03122Beclin 1, variant. (534 aa)
NCU00579Oxysterol binding protein 1; Belongs to the OSBP family. (1238 aa)
NCU01668Uncharacterized protein. (871 aa)
NCU16445Uncharacterized protein. (85 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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