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NCU07665 NCU07665 NCU05273 NCU05273 NCU05222 NCU05222 NCU01199 NCU01199 NCU04100 NCU04100 hse1 hse1 NCU05634 NCU05634 NCU05837 NCU05837 NCU06105 NCU06105 NCU02268 NCU02268 NCU05753 NCU05753 NCU06084 NCU06084 NCU05902 NCU05902 NCU08989 NCU08989 NCU05959 NCU05959 arp2 arp2 NCU04652 NCU04652 NCU06713 NCU06713 NCU04188 NCU04188 NCU04121 NCU04121 NCU01172 NCU01172 NCU01002 NCU01002 NCU02974 NCU02974 NCU03947 NCU03947 NCU09688 NCU09688 NCU06410 NCU06410 NCU06939 NCU06939 NCU06942 NCU06942 NCU04406 NCU04406 NCU00435 NCU00435 NCU03883 NCU03883 NCU08761 NCU08761 NCU05077 NCU05077 NCU04541 NCU04541 NCU00242 NCU00242 NCU09461 NCU09461 NCU07843 NCU07843 NCU06231 NCU06231 NCU07584 NCU07584 vsp-1 vsp-1 NCU06268 NCU06268 NCU07991 NCU07991 bro-1 bro-1 vps27 vps27 vma-6 vma-6 NCU01575 NCU01575 NCU01791 NCU01791 NCU01745 NCU01745 NCU05422 NCU05422 NCU08110 NCU08110 NCU02113 NCU02113 NCU00814 NCU00814 NCU07435 NCU07435 NCU08360 NCU08360 vps10 vps10 apg-13 apg-13 vsp-3 vsp-3 ssh4 ssh4 NCU04272 NCU04272 NCU05195 NCU05195 NCU01854 NCU01854 vma-3 vma-3 NCU03898 NCU03898 NCU10430 NCU10430 NCU10618 NCU10618 NCU10477 NCU10477 NCU11209 NCU11209 NCU06285 NCU06285 NCU07319 NCU07319 NCU07330 NCU07330 NCU06374 NCU06374 NCU06595 NCU06595 stk-45 stk-45 NCU06569 NCU06569
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU07665Ubiquitin-conjugating enzyme. (518 aa)
NCU05273Vps52/Sac2 family protein. (668 aa)
NCU05222CTLH domain-containing protein. (247 aa)
NCU01199SNARE domain-containing protein. (259 aa)
NCU04100Vacuolar sorting protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (706 aa)
hse1Class E vacuolar protein-sorting machinery protein hse1; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB). (745 aa)
NCU05634Uncharacterized protein. (1765 aa)
NCU05837Vacuolar protein sorting-associated protein; May be involved in recycling of membrane proteins between an endocytic compartment and the TGN; Belongs to the VPS13 family. (3209 aa)
NCU06105ADP-ribosylation factor-binding protein GGA1. (647 aa)
NCU02268Uncharacterized protein. (816 aa)
NCU05753ESCRT-I component. (580 aa)
NCU06084Uncharacterized protein. (347 aa)
NCU05902Vacuolar assembly protein. (1359 aa)
NCU08989ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (183 aa)
NCU05959Vesicle transport V-SNARE protein VTI1. (228 aa)
arp2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (395 aa)
NCU04652AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1060 aa)
NCU06713Vacuolar protein sorting protein 55. (128 aa)
NCU04188UPF0220 domain-containing protein. (173 aa)
NCU04121AP-1 complex subunit gamma. (842 aa)
NCU01172GARP complex component. (1162 aa)
NCU01002Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family. (296 aa)
NCU02974Uncharacterized protein. (438 aa)
NCU03947E3 ubiquitin-protein ligase. (817 aa)
NCU09688AP-1 complex subunit mu; Belongs to the adaptor complexes medium subunit family. (448 aa)
NCU06410GTP-binding protein YPT52. (236 aa)
NCU06939Endosome-associated ubiquitin isopeptidase. (586 aa)
NCU06942Vacuolar protein sorting-associated protein VPS4; Belongs to the AAA ATPase family. (441 aa)
NCU04406Vesicle-mediated transporter Vid24. (389 aa)
NCU00435SNF7 family protein. (227 aa)
NCU03883Vacuolar transporter chaperone 1. (127 aa)
NCU08761Vacuolar sorting receptor. (370 aa)
NCU05077Metal homeostatis protein bsd2. (359 aa)
NCU04541SNF7 family protein. (218 aa)
NCU00242V-SNARE. (562 aa)
NCU09461AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (194 aa)
NCU07843Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (267 aa)
NCU06231Vacuolar amino acid transporter 1. (688 aa)
NCU07584Vacuolar segregation protein pep7. (685 aa)
vsp-1Sorting nexin mvp1; Required for vacuolar protein sorting. (790 aa)
NCU06268Probable vacuolar protein sorting-associated protein 16 homolog; Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. (865 aa)
NCU07991DUF292 domain-containing protein. (299 aa)
bro-1Vacuolar protein-sorting protein bro-1; Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles; Belongs to the BRO1 family. (1012 aa)
vps27Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. (724 aa)
vma-6V-type proton ATPase subunit d; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. (364 aa)
NCU01575SNARE complex subunit. (292 aa)
NCU01791SNF7 family protein. (235 aa)
NCU01745SPX domain-containing protein. (800 aa)
NCU05422E3 ubiquitin-protein ligase PEP5. (1016 aa)
NCU08110Vacuolar transporter chaperone 4. (771 aa)
NCU02113Ubiquitin-conjugating enzyme E2 13; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
NCU00814Uncharacterized protein. (430 aa)
NCU07435Chitin biosynthesis protein CHS5. (454 aa)
NCU08360Uncharacterized protein. (668 aa)
vps10Vacuolar protein sorting/targeting protein 10; Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity); Belongs to the VPS10-related sortilin family. (1528 aa)
apg-13Vacuolar fusion protein mon1; Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis; Belongs to the MON1/SAND family. (678 aa)
vsp-3Vacuolar-sorting protein snf7; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH (By similarity). (228 aa)
ssh4Protein ssh4; Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity); Belongs to the SSH4 family. (503 aa)
NCU04272ZZ type zinc finger domain-containing protein, variant. (867 aa)
NCU05195Uncharacterized protein. (484 aa)
NCU01854Uncharacterized protein. (214 aa)
vma-3V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (161 aa)
NCU03898ESCRT-II complex component. (225 aa)
NCU10430SNF7 family protein. (215 aa)
NCU10618AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (155 aa)
NCU10477Ubiquitin-conjugating enzyme E2. (156 aa)
NCU11209Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (237 aa)
NCU06285N-acetylated-alpha-linked acidic dipeptidase 2. (925 aa)
NCU07319Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (858 aa)
NCU07330Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (647 aa)
NCU06374Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (710 aa)
NCU06595Vacuolar protein sorting protein. (637 aa)
stk-45Phosphoinositide 3-kinase regulatory subunit 4. (1563 aa)
NCU06569AP-3 adaptor complex subunit beta. (805 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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