STRINGSTRING
spo11 spo11 msh1 msh1 NCU07554 NCU07554 NCU04445 NCU04445 NCU06438 NCU06438 MCM7 MCM7 msh-3 msh-3 mph1 mph1 qde-3 qde-3 NCU00517 NCU00517 NCU00832 NCU00832 NCU02539 NCU02539 crf9-1 crf9-1 crf2-1 crf2-1 hel-2 hel-2 hel-1 hel-1 Prd-6 Prd-6 crf8-1 crf8-1 NCU00401 NCU00401 NCU07519 NCU07519 NCU04749 NCU04749 NCU06338 NCU06338 mlh-1 mlh-1 NCU03337 NCU03337 crf6-1 crf6-1 NCU07395 NCU07395 crf3-1 crf3-1 PIF1 PIF1 NCU09384 NCU09384 mlh-2 mlh-2 NCU06767 NCU06767 eaf-1 eaf-1 atrx atrx csb csb pms-1 pms-1 crf5-1 crf5-1 mus-51 mus-51 NCU06365 NCU06365 NCU05194 NCU05194 NCU08806 NCU08806 NCU06627 NCU06627 NCU03091 NCU03091 csa csa crf7-1 crf7-1 NCU04786 NCU04786 mus-50 mus-50 dbp-9 dbp-9 NCU09793 NCU09793 col-25 col-25 NCU05756 NCU05756 NCU02402 NCU02402 msh6 msh6 NCU08883 NCU08883 mus-41 mus-41 crf10-1 crf10-1 crf1-1 crf1-1 crf4-1 crf4-1 NCU01625 NCU01625 mus-52 mus-52 uvs-6 uvs-6 mus-25 mus-25 NCU06833 NCU06833 mei-3 mei-3 NCU08706 NCU08706 NCU05385 NCU05385 NCU01340 NCU01340 NCU03649 NCU03649 rad16 rad16 NCU03652 NCU03652 mus-8 mus-8 msh-2 msh-2 NCU01771 NCU01771 chl1 chl1 msh4 msh4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
spo11Meiosis-specific topoisomerase Spo11. (466 aa)
msh1DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1249 aa)
NCU07554Structural maintenance of chromosomes protein. (1204 aa)
NCU04445Uncharacterized protein. (1217 aa)
NCU06438DNA repair helicase RAD25. (862 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (824 aa)
msh-3DNA mismatch repair protein msh-3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh-2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh-3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bi [...] (1145 aa)
mph1ATP-dependent DNA helicase mph1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1168 aa)
qde-3RecQ family helicase. (2330 aa)
NCU00517Cell cycle checkpoint protein RAD17. (944 aa)
NCU00832Uncharacterized protein. (402 aa)
NCU02539DNA helicase; Belongs to the MCM family. (1013 aa)
crf9-1RING-13 protein. (1214 aa)
crf2-1Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1997 aa)
hel-2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (481 aa)
hel-1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
Prd-6Regulator of nonsense transcripts 1 homolog; Eliminates the production of nonsense-containing RNAs. Belongs to the DNA2/NAM7 helicase family. (1093 aa)
crf8-1TBP associated factor, variant. (1893 aa)
NCU00401Uncharacterized protein. (458 aa)
NCU07519ATP-dependent DNA helicase; Belongs to the helicase family. (813 aa)
NCU04749DNA replication helicase Dna2. (1727 aa)
NCU06338DNA topoisomerase 2. (1994 aa)
mlh-1DNA mismatch repair protein mutL, variant. (751 aa)
NCU03337ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (483 aa)
crf6-1Chromodomain helicase, variant. (1664 aa)
NCU07395DNA-binding protein SMUBP-2. (736 aa)
crf3-1SNF2-family ATP dependent chromatin remodeling factor snf21. (1482 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (931 aa)
NCU09384DNA_MISMATCH_REPAIR_2 domain-containing protein. (872 aa)
mlh-2MUTL-2. (772 aa)
NCU06767Replication factor C subunit 1. (1086 aa)
eaf-1Chromatin modification-related protein eaf-1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (2189 aa)
atrxATRX. (1869 aa)
csbDNA repair protein Rhp26/Rad26. (1173 aa)
pms-1DNA mismatch repair protein. (1157 aa)
crf5-1Chromatin remodeling factor 5-1. (907 aa)
mus-51ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (645 aa)
NCU06365DEAD/DEAH box helicase. (1175 aa)
NCU05194DNA helicase; Belongs to the MCM family. (972 aa)
NCU08806RECA_2 domain-containing protein. (442 aa)
NCU06627Uncharacterized protein. (1190 aa)
NCU03091Uncharacterized protein. (441 aa)
csaDNA excision repair protein. (1269 aa)
crf7-1Chromodomain-helicase-DNA-binding protein 4. (1726 aa)
NCU04786SNF2 family helicase/ATPase. (1197 aa)
mus-50UvrD/REP helicase. (1105 aa)
dbp-9ATP-dependent RNA helicase dbp-9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (676 aa)
NCU09793DEAD/DEAH box DNA helicase. (1563 aa)
col-25Fungal specific transcription factor. (1194 aa)
NCU05756Peptidase M4. (449 aa)
NCU02402SMC_N domain-containing protein. (1167 aa)
msh6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1246 aa)
NCU08883SNF2_N domain-containing protein. (355 aa)
mus-41DNA repair protein rad5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein uvs-2/rad18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1228 aa)
crf10-1Clockswitch protein CSW-1. (1011 aa)
crf1-1Helicase swr-1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1845 aa)
crf4-1Chromatin remodelling complex ATPase chain ISW1. (1126 aa)
NCU01625DNA repair helicase RAD3. (806 aa)
mus-52ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (725 aa)
uvs-6UVS6. (1314 aa)
mus-25DNA repair and recombination protein RAD54. (835 aa)
NCU06833UvrD_C_2 domain-containing protein. (722 aa)
mei-3DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (353 aa)
NCU08706AAA family ATPase. (622 aa)
NCU05385MutL_C domain-containing protein. (937 aa)
NCU01340Uncharacterized protein. (215 aa)
NCU03649Uncharacterized protein. (608 aa)
rad16DNA repair protein RAD16. (1079 aa)
NCU03652SNF2 family helicase/ATPase. (1548 aa)
mus-8Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
msh-2DNA mismatch repair protein msh-2; Involved in post-replicative DNA-mismatch repair. Binds to mismatch-containing DNA (By similarity). (937 aa)
NCU01771DNA repair protein rhp57. (510 aa)
chl1ATP-dependent DNA helicase chl1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (1068 aa)
msh4MutS ortholog 4 protein. (1318 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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