STRINGSTRING
atrx atrx sad-1 sad-1 NCU02968 NCU02968 dim-2 dim-2 B5K2.060 B5K2.060 NCU01493 NCU01493 NCU03517 NCU03517 NCU01248 NCU01248 NCU06405 NCU06405 NCU03505 NCU03505 NCU03860 NCU03860 NCU04091 NCU04091 ctc-1 ctc-1 ff-1 ff-1 NCU03366 NCU03366 NCU00210 NCU00210 NCU00159 NCU00159 NCU00427 NCU00427 hda-1 hda-1 NCU00019 NCU00019 NCU06479 NCU06479 NCU00120 NCU00120 NCU00118 NCU00118 NCU00093 NCU00093 NCU00415 NCU00415 vel vel NCU00366 NCU00366 hat-1 hat-1 NCU06446 NCU06446 NCU04424 NCU04424 NCU04406 NCU04406 NCU03956 NCU03956 stk-4 stk-4 NCU04073 NCU04073 NCU00363 NCU00363 NCU00334 NCU00334 NCU00319 NCU00319 vts1 vts1 NCU00293 NCU00293 cul-4 cul-4 prk-4 prk-4 NCU10046 NCU10046 NCU07364 NCU07364 NCU07358 NCU07358 NCU09152 NCU09152 crf10-1 crf10-1 nuo14 nuo14 NCU05968 NCU05968 NCU09438 NCU09438 NCU07559 NCU07559 NCU05979 NCU05979 NCU09877 NCU09877 NCU09556 NCU09556 tof-1 tof-1 NCU09542 NCU09542 NCU05945 NCU05945 NCU09130 NCU09130 NCU09120 NCU09120 NCU09357 NCU09357 NCU09001 NCU09001 fyv-10 fyv-10 un-17 un-17 mrt4 mrt4 rad23 rad23 NCU09161 NCU09161 NCU09159 NCU09159 nst-4 nst-4 sad-3 sad-3 trf-3 trf-3 NCU04927 NCU04927 NCU02382 NCU02382 NCU02424 NCU02424 rtt-106 rtt-106 msh6 msh6 NCU05861 NCU05861 NCU02256 NCU02256 hat-5 hat-5 drh-10 drh-10 hat-6 hat-6 NCU04718 NCU04718 NCU04766 NCU04766 NCU07080 NCU07080 NCU07078 NCU07078 NCU07072 NCU07072 NCU07071 NCU07071 nst-1 nst-1 NCU05608 NCU05608 NCU05540 NCU05540 NCU09681 NCU09681 NCU01409 NCU01409 crf7-1 crf7-1 NCU04101 NCU04101 NCU06678 NCU06678 NCU01097 NCU01097 NCU05267 NCU05267 NCU06627 NCU06627 NCU05222 NCU05222 dcl-1 dcl-1 NCU05246 NCU05246 NCU05244 NCU05244 NCU05300 NCU05300 NCU07297 NCU07297 NCU07294 NCU07294 NCU07036 NCU07036 esa-1 esa-1 NCU06540 NCU06540 LSM4 LSM4 NCU07679 NCU07679 NCU06623 NCU06623 dim-8 dim-8 mus-51 mus-51 NCU06331 NCU06331 NCU06316 NCU06316 atp25 atp25 NCU06998 NCU06998 NCU06993 NCU06993 NCU08009 NCU08009 NCU07975 NCU07975 NCU07874 NCU07874 nst-7 nst-7 NCU07889 NCU07889 dot-1 dot-1 NCU06204 NCU06204 NCU06199 NCU06199 drh-1 drh-1 stk-40 stk-40 NCU07852 NCU07852 NCU07843 NCU07843 dcl-2 dcl-2 nst-3 nst-3 nst-2 nst-2 NCU03244 NCU03244 NCU09365 NCU09365 NCU03065 NCU03065 fmf-1 fmf-1 NCU09380 NCU09380 NCU09378 NCU09378 mus-59 mus-59 MCM7 MCM7 NCU01855 NCU01855 NCU02104 NCU02104 NCU01930 NCU01930 par-2 par-2 NCU02134 NCU02134 set-8 set-8 hda-3 hda-3 NCU00812 NCU00812 chc-1 chc-1 NCU03273 NCU03273 NCU03268 NCU03268 prd-4 prd-4 NCU02800 NCU02800 NCU03178 NCU03178 NCU03159 NCU03159 NCU02076 NCU02076 NCU07455 NCU07455 NCU00898 NCU00898 ada-2 ada-2 NCU00798 NCU00798 NCU07505 NCU07505 NCU07495 NCU07495 NCU03232 NCU03232 NCU02964 NCU02964 csp-1 csp-1 npl4 npl4 NCU02661 NCU02661 NCU01919 NCU01919 NCU01884 NCU01884 csm-3 csm-3 NCU01857 NCU01857 NCU02932 NCU02932 NCU02913 NCU02913 NCU02540 NCU02540 NCU02521 NCU02521 NCU00693 NCU00693 NCU00690 NCU00690 NCU00611 NCU00611 crc-1 crc-1 hH2Az hH2Az hH1 hH1 spt-6 spt-6 exr-1 exr-1 B24G3.190 B24G3.190 hh2a hh2a ccr4 ccr4 rai1 rai1 Prd-6 Prd-6 asd-4 asd-4 ypi-1 ypi-1 drh-9 drh-9 crp-46 crp-46 NCU06511 NCU06511 crf8-1 crf8-1 NCU04790 NCU04790 NCU03855 NCU03855 NCU03965 NCU03965 NCU04617 NCU04617 LSM5 LSM5 NCU03768 NCU03768 NCU02404 NCU02404 NCU03981 NCU03981 NCU10547 NCU10547 NCU07079 NCU07079 NCU16966 NCU16966 NCU16972 NCU16972 NCU09866 NCU09866 NCU04369 NCU04369 NCU08948 NCU08948 rcm-1 rcm-1 NCU08955 NCU08955 NCU16822 NCU16822 NCU08049 NCU08049 NCU01496 NCU01496 NCU16328 NCU16328 NCU16771 NCU16771 NCU04364 NCU04364 NCU05343 NCU05343 un-1 un-1 NCU05375 NCU05375 NCU00879 NCU00879 NCU16397 NCU16397 NCU01762 NCU01762 cdp-2 cdp-2 NCU08378 NCU08378 NCU02688 NCU02688 NCU02547 NCU02547 NCU08362 NCU08362 NCU03274 NCU03274 NCU16560 NCU16560 NCU01668 NCU01668 NCU00550 NCU00550 NCU02578 NCU02578 NCU03048 NCU03048 NCU01599 NCU01599 NCU01760 NCU01760 NCU01737 NCU01737 NCU03905 NCU03905 NCU10185 NCU10185 NCU01501 NCU01501 NCU10538 NCU10538 NCU10809 NCU10809 snr-6 snr-6 NCU08713 NCU08713 NCU10622 NCU10622 NCU11109 NCU11109 NCU11050 NCU11050 NCU10904 NCU10904 NCU01461 NCU01461 NCU01457 NCU01457 cre-1 cre-1 par-1 par-1 nit-2 nit-2 nmr nmr mus-8 mus-8 rco-1 rco-1 ccg-8 ccg-8 cpc-2 cpc-2 mcb mcb NCU03329 NCU03329 NCU01495 NCU01495 NCU01806 NCU01806 chap chap LSM1 LSM1 NCU01844 NCU01844 tng tng NCU03435 NCU03435 hpo hpo NCU03898 NCU03898 NCU04009 NCU04009 pp-1 pp-1 NCU09929 NCU09929 NCU04615 NCU04615 NCU04597 NCU04597 qde-1 qde-1 NCU01377 NCU01377 NCU04325 NCU04325 mrc1 mrc1 NCU04187 NCU04187 NCU04155 NCU04155 dim-7 dim-7 hsp80 hsp80 NCU04139 NCU04139 NCU01315 NCU01315 NCU01310 NCU01310 gul-1 gul-1 NCU01171 NCU01171 NCU01078 NCU01078 sre sre NCU08472 NCU08472 NCU06856 NCU06856 rrp3 rrp3 NCU06838 NCU06838 NCU06790 NCU06790
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
atrxATRX. (1869 aa)
sad-1RNA dependent RNA polymerase. (1638 aa)
NCU02968TMF_TATA_bd domain-containing protein. (900 aa)
dim-2DNA methyltransferase Dim-2. (1454 aa)
B5K2.060FAS1 domain-containing protein NCU02579. (228 aa)
NCU01493Uncharacterized protein. (382 aa)
NCU03517Ski8. (342 aa)
NCU01248Telo_bind domain-containing protein. (735 aa)
NCU06405DNA polymerase epsilon subunit C. (404 aa)
NCU03505JmjC domain-containing histone demethylation protein 3D. (1977 aa)
NCU03860mRNA stability protein; Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway. (167 aa)
NCU04091Uncharacterized protein. (422 aa)
ctc-1FACT complex subunit ctc-1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (565 aa)
ff-1PTAB. (794 aa)
NCU03366Uncharacterized protein. (587 aa)
NCU00210Nuclear cap-binding protein subunit 2. (194 aa)
NCU00159Sin3-associated polypeptide Sap18. (264 aa)
NCU00427Uncharacterized protein. (801 aa)
hda-1Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (744 aa)
NCU00019FKH1. (688 aa)
NCU06479Uncharacterized protein. (363 aa)
NCU00120Uncharacterized protein. (1237 aa)
NCU00118RRM domain-containing protein. (713 aa)
NCU00093Uncharacterized protein. (177 aa)
NCU00415Uncharacterized protein. (1033 aa)
velNon-specific serine/threonine protein kinase. (833 aa)
NCU00366Eukaryotic translation initiation factor 5. (425 aa)
hat-1Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (508 aa)
NCU06446Uncharacterized protein. (489 aa)
NCU04424Uncharacterized protein. (478 aa)
NCU04406Vesicle-mediated transporter Vid24. (389 aa)
NCU03956Plus3 domain-containing protein. (601 aa)
stk-4Serine/threonine-protein kinase ste20; MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (954 aa)
NCU04073Uncharacterized protein. (1618 aa)
NCU00363Uncharacterized protein. (761 aa)
NCU003343' exoribonuclease. (297 aa)
NCU00319Uncharacterized protein. (242 aa)
vts1Protein VTS1; RNA-binding protein involved in post-transcriptional regulation through transcript degradation. May be involved in vacuolar protein transport (By similarity). (620 aa)
NCU00293NADH pyrophosphatase. (511 aa)
cul-4Ubiquitin ligase subunit CulD; Belongs to the cullin family. (1039 aa)
prk-4Protein kinase lkh1. (732 aa)
NCU10046Ubiquitin conjugating enzyme Ubc8; Belongs to the ubiquitin-conjugating enzyme family. (162 aa)
NCU07364Uncharacterized protein. (381 aa)
NCU07358Helicase C-terminal domain-containing protein. (1206 aa)
NCU09152Uncharacterized protein. (527 aa)
crf10-1Clockswitch protein CSW-1. (1011 aa)
nuo14NADH:ubiquinone oxidoreductase 14kD subunit. (121 aa)
NCU05968Uncharacterized protein. (544 aa)
NCU09438Translation repressor/antiviral protein Ski3. (1444 aa)
NCU07559Uncharacterized protein. (499 aa)
NCU05979RXT2_N domain-containing protein. (580 aa)
NCU09877Uncharacterized protein. (424 aa)
NCU09556Homeobox domain-containing protein. (727 aa)
tof-1Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with csm-3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1235 aa)
NCU09542Impact family protein. (299 aa)
NCU05945Uncharacterized protein. (408 aa)
NCU09130Uncharacterized protein. (693 aa)
NCU09120Lysine-specific histone demethylase Aof2. (1374 aa)
NCU09357Stage V sporulation protein K. (2307 aa)
NCU09001CCR4-NOT transcription complex subunit 7. (572 aa)
fyv-10Protein fyv-10; Involved in the proteasome-dependent degradation of fructose- 1,6-bisphosphatase; Belongs to the FYV10 family. (410 aa)
un-17Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (632 aa)
mrt4Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (252 aa)
rad23Rad23-like protein. (383 aa)
NCU09161Protein DOM34 homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (407 aa)
NCU09159Uncharacterized protein. (749 aa)
nst-4Hst3p. (1327 aa)
sad-3Suppressor of ascus dominance-3 protein. (1160 aa)
trf-3Transcription elongation factor spt5; The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (1054 aa)
NCU04927Uncharacterized protein. (688 aa)
NCU02382Ubiquitin carboxyl-terminal hydrolase. (522 aa)
NCU02424DnaJ and TPR domain-containing protein. (517 aa)
rtt-106Histone chaperone rtt-106; Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity). (469 aa)
msh6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1246 aa)
NCU05861Uncharacterized protein. (1640 aa)
NCU02256Exosome complex exonuclease Rrp6. (822 aa)
hat-5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (742 aa)
drh-10ATP-dependent RNA helicase dhh1; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (569 aa)
hat-6Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1188 aa)
NCU04718DUF1752 domain-containing protein. (573 aa)
NCU04766Ccr4-Not transcription complex subunit. (2098 aa)
NCU07080GFO_IDH_MocA domain-containing protein. (395 aa)
NCU07078Uncharacterized protein. (326 aa)
NCU07072Galactose-1-phosphate uridylyltransferase. (549 aa)
NCU07071Cell differentiation protein rcd1. (356 aa)
nst-1Chromatin regulatory protein sir2. (670 aa)
NCU05608Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2443 aa)
NCU05540Uncharacterized protein. (383 aa)
NCU09681Uncharacterized protein. (589 aa)
NCU01409Ran-binding protein. (721 aa)
crf7-1Chromodomain-helicase-DNA-binding protein 4. (1726 aa)
NCU04101WD domain-containing protein. (606 aa)
NCU066785'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1450 aa)
NCU01097Zn(2)-C6 fungal-type domain-containing protein. (817 aa)
NCU05267Nonsense-mediated mRNA decay factor. (1140 aa)
NCU06627Uncharacterized protein. (1190 aa)
NCU05222CTLH domain-containing protein. (247 aa)
dcl-1ATP-dependent helicase dcl-1; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume. (1584 aa)
NCU05246DNA repair and recombination protein RAD5C. (1111 aa)
NCU05244Thioesterase. (314 aa)
NCU05300WD_REPEATS_REGION domain-containing protein. (685 aa)
NCU07297PHD-type domain-containing protein. (605 aa)
NCU07294Nefa_Nip30_N domain-containing protein. (387 aa)
NCU070363'-5' exonuclease domain-containing protein. (251 aa)
esa-1Histone acetyltransferase esa-1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recr [...] (506 aa)
NCU06540Topisomerase II associated protein. (827 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (130 aa)
NCU07679Structural maintenance of chromosomes protein. (1179 aa)
NCU06623CBFD_NFYB_HMF domain-containing protein. (304 aa)
dim-8DNA damage-binding protein 1. (1158 aa)
mus-51ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (645 aa)
NCU06331Uncharacterized protein. (448 aa)
NCU06316Uncharacterized protein. (536 aa)
atp25ATPase synthesis protein 25, mitochondrial; Probable mitochondrial mRNA stabilization factor. Belongs to the ATP25 family. (699 aa)
NCU06998Scavenger mRNA decapping enzyme. (353 aa)
NCU06993Ash2-trithorax family protein. (581 aa)
NCU08009DNA helicase; Belongs to the MCM family. (944 aa)
NCU07975DNA repair and recombination protein RAD5B. (950 aa)
NCU07874Nuclear and cytoplasmic polyadenylated RNA-binding protein pub1. (480 aa)
nst-7Transcriptional regulator. (373 aa)
NCU07889Nudix hydrolase domain-containing protein. (907 aa)
dot-1Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (531 aa)
NCU06204Uncharacterized protein. (525 aa)
NCU06199RNA binding protein Jsn1. (1208 aa)
drh-1ATP-dependent RNA helicase dbp2; ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing. (562 aa)
stk-40Serine/threonine protein kinase. (1221 aa)
NCU07852Ribosomal protein L13. (183 aa)
NCU07843Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (267 aa)
dcl-2ATP-dependent helicase dcl-2; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume. (1534 aa)
nst-3SIR2 family histone deacetylase. (647 aa)
nst-2NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (377 aa)
NCU03244WD repeat protein. (571 aa)
NCU09365YTH domain-containing protein. (707 aa)
NCU03065Mitotic control protein dis3; Belongs to the RNR ribonuclease family. (984 aa)
fmf-1Female and male fertility protein 1. (614 aa)
NCU09380Pumilio domain-containing protein. (679 aa)
NCU09378DNA-directed RNA polymerase II polypeptide. (146 aa)
mus-59Serine/threonine-protein kinase. (1233 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (824 aa)
NCU01855NTP_transf_9 domain-containing protein. (162 aa)
NCU02104WD domain-containing protein. (473 aa)
NCU01930U6 snRNP-associated protein Lsm7. (143 aa)
par-2PAN2-PAN3 deadenylation complex subunit pan3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pabp-1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' e [...] (656 aa)
NCU02134Transcription factor. (880 aa)
set-8SET-8. (1442 aa)
hda-3Histone deacetylase RPD3. (658 aa)
NCU00812Exosome complex exonuclease RRP41. (273 aa)
chc-1Conidiation at high carbon dioxide-1 protein. (422 aa)
NCU03273NF-X1 finger transcription factor. (1241 aa)
NCU03268RNase_PH domain-containing protein. (251 aa)
prd-4Serine/threonine-protein kinase chk2. (702 aa)
NCU02800Arsenite resistance protein Ars2. (900 aa)
NCU03178PHD-type domain-containing protein. (580 aa)
NCU031593' exoribonuclease. (357 aa)
NCU02076Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (248 aa)
NCU07455Uncharacterized protein. (544 aa)
NCU00898Uncharacterized protein. (465 aa)
ada-2CBF/NF-Y family transcription factor. (138 aa)
NCU00798Uncharacterized protein. (312 aa)
NCU07505Mito ribosomal protein L18. (537 aa)
NCU07495Sphingolipid long chain base-responsive protein LSP1. (374 aa)
NCU03232RNA binding protein Pym. (198 aa)
NCU02964Uncharacterized protein. (432 aa)
csp-1Conidial separation-1. (287 aa)
npl4Nuclear protein localization protein 4; Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity); Belongs to the NPL4 family. (660 aa)
NCU02661DNA-directed RNA polymerase II polypeptide. (171 aa)
NCU01919Ubiquitin carboxyl-terminal hydrolase. (548 aa)
NCU01884DUF2439 domain-containing protein. (1053 aa)
csm-3Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with tof-1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (409 aa)
NCU01857DEAD/DEAH box RNA helicase. (1294 aa)
NCU02932mRNA stability protein; Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway. (199 aa)
NCU02913DNA repair protein rad5. (679 aa)
NCU02540Meiotic expression up-regulated protein 14. (339 aa)
NCU02521Uncharacterized protein. (489 aa)
NCU00693Exosome complex exonuclease RRP40. (246 aa)
NCU00690Ribonuclease P complex subunit Pop1. (930 aa)
NCU00611EST1_DNA_bind domain-containing protein. (779 aa)
crc-1SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (733 aa)
hH2AzHistone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (143 aa)
hH1Histone H1; Could act as an H1-type linker histone; Belongs to the histone H1/H5 family. (236 aa)
spt-6Transcription elongation factor spt-6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1402 aa)
exr-15'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity); Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (1072 aa)
B24G3.190Uncharacterized protein B24G3.190; Belongs to the protease inhibitor I9 family. (94 aa)
hh2aHistone H2A; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (134 aa)
ccr4Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (793 aa)
rai1Decapping nuclease rai1; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). Belongs to the DXO/Dom3Z family. (412 aa)
Prd-6Regulator of nonsense transcripts 1 homolog; Eliminates the production of nonsense-containing RNAs. Belongs to the DNA2/NAM7 helicase family. (1093 aa)
asd-4GATA type zinc finger protein asd-4; Transcriptional regulator that functions in sexual development; disruption of asd-4 gene results in agenesis of ascus and ascospore with macroscopically normal fruiting body formation. The GATA-type zinc finger domain binds to DNA sequences from its own promoter region. (426 aa)
ypi-1Type 1 phosphatases regulator ypi-1; Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control; Belongs to the YPI1 family. (186 aa)
drh-9ATP-dependent RNA helicase ded1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (688 aa)
crp-4660S ribosomal protein L16; Belongs to the universal ribosomal protein uL13 family. (202 aa)
NCU06511PUM-HD domain-containing protein. (833 aa)
crf8-1TBP associated factor, variant. (1893 aa)
NCU04790Eukaryotic peptide chain release factor GTP-binding subunit. (730 aa)
NCU03855CCR4-NOT transcription complex, variant. (640 aa)
NCU03965Catabolite repression protein creC. (643 aa)
NCU04617CCHC-type domain-containing protein. (756 aa)
LSM5U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (84 aa)
NCU03768Lysophospholipase, variant 1. (595 aa)
NCU02404RNP domain-containing protein, variant 1. (483 aa)
NCU03981Elongation factor Tu GTP binding domain-containing protein. (782 aa)
NCU10547Uncharacterized protein. (510 aa)
NCU07079Uncharacterized protein. (652 aa)
NCU16966Uncharacterized protein. (77 aa)
NCU16972Uncharacterized protein. (302 aa)
NCU09866Thyroid hormone receptor interactor 12. (2020 aa)
NCU04369Uncharacterized protein. (561 aa)
NCU08948NIF domain-containing protein, variant. (531 aa)
rcm-1RCM-1, variant. (917 aa)
NCU08955UBX domain-containing protein, variant. (317 aa)
NCU16822Inhibitor I9 domain-containing protein. (115 aa)
NCU08049Zn(2)-C6 fungal-type domain-containing protein. (991 aa)
NCU01496Stc1 domain-containing protein. (376 aa)
NCU16328Uncharacterized protein. (254 aa)
NCU16771Rpp14 family protein. (187 aa)
NCU04364PAP-associated domain-containing protein. (1187 aa)
NCU05343R3H domain-containing protein. (645 aa)
un-1Serine/threonine protein kinase. (620 aa)
NCU05375Uncharacterized protein. (1707 aa)
NCU00879WD domain-containing protein, variant. (352 aa)
NCU16397Nuclear polyadenylated RNA-binding protein Nab2. (522 aa)
NCU01762Nucleolar RNAse III, variant. (352 aa)
cdp-2Chromodomain protein-2, variant. (572 aa)
NCU08378Ubiquitin carboxyl-terminal hydrolase. (849 aa)
NCU02688Ubiquitin-conjugating enzyme E2Z. (451 aa)
NCU02547Thioredoxin-like_fold domain-containing protein. (276 aa)
NCU08362Chromo domain-containing protein. (353 aa)
NCU03274zf-LYAR domain-containing protein. (422 aa)
NCU16560PUM-HD domain-containing protein. (992 aa)
NCU01668Uncharacterized protein. (871 aa)
NCU00550zf-C3H1 domain-containing protein. (1226 aa)
NCU02578Paired amphipathic helix protein Sin3a, variant. (1490 aa)
NCU03048CCCH zinc finger protein. (441 aa)
NCU01599Uncharacterized protein. (570 aa)
NCU01760Pumilio-family RNA binding repeat protein. (776 aa)
NCU01737Uncharacterized protein. (1051 aa)
NCU03905BZIP domain-containing protein. (577 aa)
NCU10185tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (471 aa)
NCU01501Mitochondrial peptidyl-tRNA hydrolase Pth2. (330 aa)
NCU10538Clr5 domain-containing protein. (438 aa)
NCU10809Uncharacterized protein. (830 aa)
snr-6U6 snRNA-associated Sm-like protein LSm6; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2- LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 [...] (82 aa)
NCU08713Uncharacterized protein. (428 aa)
NCU10622Uncharacterized protein. (221 aa)
NCU11109ORM1. (180 aa)
NCU11050DUF455 domain-containing protein. (1368 aa)
NCU10904UPF0029 domain-containing protein. (579 aa)
NCU01461Uncharacterized protein. (1325 aa)
NCU01457Ubiquitin C-terminal hydrolase; Belongs to the peptidase C19 family. (755 aa)
cre-1DNA-binding protein cre-1; Involved in carbon catabolite repression. Represses the transcription of a number of genes by binding to a GC-rich region in their promoter (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. (430 aa)
par-1PAN2-PAN3 deadenylation complex catalytic subunit pan2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pabp-1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequen [...] (1310 aa)
nit-2Nitrogen catabolic enzyme regulatory protein; Major nitrogen regulatory protein. During conditions of nitrogen limitation it turns on the expression of genes for enzymes which are required for the use of a variety of secondary nitrogen sources, including nitrates, purines, amino acids, and proteins. (1036 aa)
nmrNitrogen metabolite repression protein nmr; May be a redox sensor protein. Negative transcriptional regulator involved in the post-transcriptional modulation of the GATA- type transcription factor nit-2, forming part of a system controlling nitrogen metabolite repression (By similarity). (488 aa)
mus-8Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
rco-1Transcriptional repressor rco-1; Represses transcription by RNA polymerase II. May be involved at several stages of conidiation and other growth and development processes. Appears to regulate genes that are expressed in asexual and sexual spore pathways. (604 aa)
ccg-8Clock-controlled protein 8. (661 aa)
cpc-2Guanine nucleotide-binding protein subunit beta-like protein; Required to activate general amino acid control under conditions of amino acid limitation in the vegetative growth phase, and for formation of protoperithecia in preparation for the sexual phase of the life cycle of N.crassa. (316 aa)
mcbcAMP-dependent protein kinase regulatory subunit. (385 aa)
NCU03329Uncharacterized protein. (294 aa)
NCU01495Uncharacterized protein. (902 aa)
NCU018063' exoribonuclease. (391 aa)
chapCDP-2-and HDA-1 associating protein. (552 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation. (188 aa)
NCU01844Uncharacterized protein. (240 aa)
tngSerine/threonine-protein phosphatase. (388 aa)
NCU03435RRM domain-containing protein. (839 aa)
hpoHeterochromatin protein 1. (266 aa)
NCU03898ESCRT-II complex component. (225 aa)
NCU04009Exosome complex exonuclease Rrp4. (387 aa)
pp-1Transcription factor steA. (722 aa)
NCU09929Uncharacterized protein. (281 aa)
NCU04615Osmolarity two-component system protein sln1. (1266 aa)
NCU04597Repressor of RNA polymerase III transcription MAF1; Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. (391 aa)
qde-1RNA-dependent RNA polymerase. (1402 aa)
NCU01377Anaphase-promoting complex subunit Cut9. (654 aa)
NCU04325Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (760 aa)
mrc1MRC1. (1464 aa)
NCU04187Cap binding protein. (829 aa)
NCU04155Exosome component 1. (214 aa)
dim-7Defective in methylation-7 protein. (666 aa)
hsp80Heat shock protein 80. (705 aa)
NCU04139Flavin_Reduct domain-containing protein. (357 aa)
NCU01315UDP-N-acetylglucosaminyltransferase. (1655 aa)
NCU01310Uncharacterized protein. (484 aa)
gul-1Cell wall biogenesis protein phosphatase Ssd1. (1365 aa)
NCU01171DNA helicase; Belongs to the MCM family. (724 aa)
NCU01078D-mandelate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (442 aa)
sreGATA-type transcription factor sre; GATA-type transcription repressor that regulates iron- acquisition genes through specific binding the GATA sequence elements of target promoters in a zinc-dependent manner. Iron acquisition regulation is critical for survival under both iron-limiting conditions (to acquire essential iron) and iron-replete conditions (to limit iron toxicity). Represses the synthesis of siderophores in high iron conditions. (587 aa)
NCU08472Uncharacterized protein. (425 aa)
NCU06856Ubiquitin fusion degradation protein. (382 aa)
rrp3RNA-dependent RNA polymerase. (1351 aa)
NCU06838Uncharacterized protein. (648 aa)
NCU06790Uncharacterized protein. (281 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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