32 items (Neurospora crassa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Others

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protein homology

Your Input:
	mus-8	Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	cpc-2	Guanine nucleotide-binding protein subunit beta-like protein; Required to activate general amino acid control under conditions of amino acid limitation in the vegetative growth phase, and for formation of protoperithecia in preparation for the sexual phase of the life cycle of N.crassa. (316 aa)
	gna-2	Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. (355 aa)
	NCU01798	Uncharacterized protein. (889 aa)
	cpc-3	Cpc-3 protein. (1646 aa)
	NCU00434	Protein phosphatase 2C isoform beta. (619 aa)
	NCU06479	Uncharacterized protein. (363 aa)
	mus-21	Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2939 aa)
	NCU00237	cAMP-specific phosphodiesterase. (698 aa)
	NCU10028	Bax Inhibitor family protein. (352 aa)
	nuo14	NADH:ubiquinone oxidoreductase 14kD subunit. (121 aa)
	NCU09565	Uncharacterized protein; Belongs to the cytochrome P450 family. (554 aa)
	NCU02244	C2 domain-containing protein. (592 aa)
	NCU06122	GTPase activating protein Sar1. (780 aa)
	iml1	Vacuolar membrane-associated protein iml1. (2004 aa)
	NCU07707	FNIP_N domain-containing protein. (1229 aa)
	NCU06989	Senescence domain-containing protein. (518 aa)
	NCU06252	Uncharacterized protein. (811 aa)
	NCU06269	FHA domain-containing protein. (790 aa)
	NCU00520	Oxidoreductase. (663 aa)
	NCU02725	Uncharacterized protein. (984 aa)
	NCU03237	Mitotic check point protein. (536 aa)
	NCU03029	Uncharacterized protein. (623 aa)
	amyc	LIM and Rho-GAP domain-containing protein. (1279 aa)
	NCU02524	Rho GAP domain-containing protein. (1464 aa)
	pph-3	Serine/threonine-protein phosphatase PP1; Belongs to the PPP phosphatase family. PP-1 subfamily. (308 aa)
	NCU08331	Uncharacterized protein. (1008 aa)
	NCU04105	Rap-GAP domain-containing protein. (1655 aa)
	rgb-1	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (481 aa)
	NCU00879	WD domain-containing protein, variant. (352 aa)
	NCU08319	Developmental regulator flbA. (766 aa)
	NCU01584	Uncharacterized protein. (1012 aa)

Your Current Organism:

Neurospora crassa

NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NCU00434	NCU06252	Q7RXS5	Q7SB61	Protein phosphatase 2C isoform beta.	Uncharacterized protein.	0.428
NCU01584	NCU03237	V5IR46	Q7SGT3	Uncharacterized protein.	Mitotic check point protein.	0.858
NCU01798	gna-2	Q1K550	Q05424	Uncharacterized protein.	Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily.	0.677
NCU02524	amyc	Q7SHT9	Q7SH40	Rho GAP domain-containing protein.	LIM and Rho-GAP domain-containing protein.	0.555
NCU02725	NCU03029	Q7SGC4	Q7SGY7	Uncharacterized protein.	Uncharacterized protein.	0.999
NCU02725	NCU04105	Q7SGC4	V5IPH2	Uncharacterized protein.	Rap-GAP domain-containing protein.	0.486
NCU02725	iml1	Q7SGC4	Q7S9J6	Uncharacterized protein.	Vacuolar membrane-associated protein iml1.	0.999
NCU03029	NCU02725	Q7SGY7	Q7SGC4	Uncharacterized protein.	Uncharacterized protein.	0.999
NCU03029	NCU04105	Q7SGY7	V5IPH2	Uncharacterized protein.	Rap-GAP domain-containing protein.	0.472
NCU03029	iml1	Q7SGY7	Q7S9J6	Uncharacterized protein.	Vacuolar membrane-associated protein iml1.	0.999
NCU03237	NCU01584	Q7SGT3	V5IR46	Mitotic check point protein.	Uncharacterized protein.	0.858
NCU03237	NCU06269	Q7SGT3	Q7SB71	Mitotic check point protein.	FHA domain-containing protein.	0.634
NCU03237	rgb-1	Q7SGT3	V5IPN6	Mitotic check point protein.	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.963
NCU04105	NCU02725	V5IPH2	Q7SGC4	Rap-GAP domain-containing protein.	Uncharacterized protein.	0.486
NCU04105	NCU03029	V5IPH2	Q7SGY7	Rap-GAP domain-containing protein.	Uncharacterized protein.	0.472
NCU04105	NCU08331	V5IPH2	V5IMF2	Rap-GAP domain-containing protein.	Uncharacterized protein.	0.972
NCU06252	NCU00434	Q7SB61	Q7RXS5	Uncharacterized protein.	Protein phosphatase 2C isoform beta.	0.428
NCU06269	NCU03237	Q7SB71	Q7SGT3	FHA domain-containing protein.	Mitotic check point protein.	0.634
NCU06269	mus-21	Q7SB71	Q7RZT9	FHA domain-containing protein.	Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).	0.558
NCU08319	gna-2	V5IQ27	Q05424	Developmental regulator flbA.	Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily.	0.898

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