STRINGSTRING
ngf-1 ngf-1 NCU10760 NCU10760 NCU08475 NCU08475 NCU06788 NCU06788 NCU01599 NCU01599 mus-8 mus-8 act act NCU07174 NCU07174 NCU01315 NCU01315 NCU06838 NCU06838 NCU06787 NCU06787 B5K2.060 B5K2.060 NCU03517 NCU03517 NCU03461 NCU03461 NCU03885 NCU03885 NCU00444 NCU00444 NCU00423 NCU00423 hda-1 hda-1 NCU04459 NCU04459 stk-13 stk-13 NCU00095 NCU00095 NCU00407 NCU00407 vel vel hat-1 hat-1 NCU06446 NCU06446 stk-42 stk-42 stk-4 stk-4 yaf9 yaf9 NCU00296 NCU00296 mus-21 mus-21 set-2 set-2 NCU07419 NCU07419 NCU07412 NCU07412 NCU09825 NCU09825 asf-1 asf-1 NCU05979 NCU05979 NCU09877 NCU09877 NCU09130 NCU09130 NCU09120 NCU09120 upl-1 upl-1 nst-4 nst-4 NCU06882 NCU06882 NCU06037 NCU06037 NCU09569 NCU09569 NCU02375 NCU02375 NCU02367 NCU02367 bdp-2 bdp-2 hat-5 hat-5 hat-6 hat-6 NCU04761 NCU04761 stk-18 stk-18 hat-2 hat-2 NCU05300 NCU05300 esa-1 esa-1 NCU06993 NCU06993 NCU08047 NCU08047 NCU07992 NCU07992 nst-7 nst-7 NCU07885 NCU07885 dot-1 dot-1 hlm-1 hlm-1 eaf-1 eaf-1 set-6 set-6 NCU08729 NCU08729 nst-3 nst-3 NCU03244 NCU03244 NCU03037 NCU03037 NCU02104 NCU02104 set-3 set-3 NCU03138 NCU03138 eaf6 eaf6 hda-3 hda-3 NCU03315 NCU03315 NCU03178 NCU03178 NCU00577 NCU00577 set-7 set-7 NCU02962 NCU02962 hat-2-2 hat-2-2 arp-4 arp-4 crc-1 crc-1 hel-2 hel-2 hel-1 hel-1 set-1 set-1 dim-5 dim-5 nop-1 nop-1 NCU16790 NCU16790 pp-2 pp-2 NCU01534 NCU01534 NCU02547 NCU02547 NCU02578 NCU02578
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ngf-1Histone acetyltransferase GCN5. (410 aa)
NCU10760Jumonji domain-containing protein 5. (617 aa)
NCU08475Post-SET domain-containing protein. (328 aa)
NCU06788Chromo domain-containing protein. (145 aa)
NCU01599Uncharacterized protein. (570 aa)
mus-8Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
actActin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (375 aa)
NCU07174SGF29 C-terminal domain-containing protein. (461 aa)
NCU01315UDP-N-acetylglucosaminyltransferase. (1655 aa)
NCU06838Uncharacterized protein. (648 aa)
NCU06787MRG domain-containing protein. (366 aa)
B5K2.060FAS1 domain-containing protein NCU02579. (228 aa)
NCU03517Ski8. (342 aa)
NCU03461Chromatin modification-related protein. (824 aa)
NCU03885Uncharacterized protein. (680 aa)
NCU00444Transcription initiation factor TFIID subunit 14. (226 aa)
NCU00423PHD-type domain-containing protein. (1413 aa)
hda-1Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (744 aa)
NCU04459Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. (522 aa)
stk-13Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (420 aa)
NCU00095Tetratricopeptide repeat protein 1. (1279 aa)
NCU00407Protein kinase domain-containing protein. (689 aa)
velNon-specific serine/threonine protein kinase. (833 aa)
hat-1Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (508 aa)
NCU06446Uncharacterized protein. (489 aa)
stk-42Serine/threonine protein kinase-42. (562 aa)
stk-4Serine/threonine-protein kinase ste20; MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (954 aa)
yaf9Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (309 aa)
NCU00296SET domain-containing protein. (510 aa)
mus-21Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2939 aa)
set-2Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that trimethylates histone H3 'Lys- 36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (954 aa)
NCU07419F-box domain-containing protein. (511 aa)
NCU07412PHD finger and BAH domain-containing protein. (1842 aa)
NCU09825Histone acetyltransferase. (630 aa)
asf-1Histone chaperone asf-1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (271 aa)
NCU05979RXT2_N domain-containing protein. (580 aa)
NCU09877Uncharacterized protein. (424 aa)
NCU09130Uncharacterized protein. (693 aa)
NCU09120Lysine-specific histone demethylase Aof2. (1374 aa)
upl-1E3 ubiquitin-protein ligase bre1; E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation; Belongs to the BRE1 family. (724 aa)
nst-4Hst3p. (1327 aa)
NCU06882RBR-type E3 ubiquitin transferase. (537 aa)
NCU06037N-acetyltransferase domain-containing protein. (280 aa)
NCU09569Uncharacterized protein. (533 aa)
NCU02375Ubiquitinyl hydrolase 1. (522 aa)
NCU02367HAD_SAK_1 domain-containing protein. (732 aa)
bdp-2Transcriptional activator spt7. (1172 aa)
hat-5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (742 aa)
hat-6Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1188 aa)
NCU04761Uncharacterized protein. (568 aa)
stk-18Histone acetylase complex subunit Paf400; Belongs to the PI3/PI4-kinase family. (3895 aa)
hat-2Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. (446 aa)
NCU05300WD_REPEATS_REGION domain-containing protein. (685 aa)
esa-1Histone acetyltransferase esa-1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recr [...] (506 aa)
NCU06993Ash2-trithorax family protein. (581 aa)
NCU08047Uncharacterized protein. (784 aa)
NCU07992Spt3. (562 aa)
nst-7Transcriptional regulator. (373 aa)
NCU07885WD repeat containing protein 82. (377 aa)
dot-1Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (531 aa)
hlm-1Histone-lysine N-methyltransferase set9; Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3. (777 aa)
eaf-1Chromatin modification-related protein eaf-1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (2189 aa)
set-6SET-6. (320 aa)
NCU08729Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (245 aa)
nst-3SIR2 family histone deacetylase. (647 aa)
NCU03244WD repeat protein. (571 aa)
NCU03037Uncharacterized protein. (200 aa)
NCU02104WD domain-containing protein. (473 aa)
set-3SET-3. (1238 aa)
NCU03138Transcription initiation factor TFIID. (320 aa)
eaf6Chromatin modification-related protein eaf6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (187 aa)
hda-3Histone deacetylase RPD3. (658 aa)
NCU03315Uncharacterized protein. (407 aa)
NCU03178PHD-type domain-containing protein. (580 aa)
NCU00577Uncharacterized protein. (398 aa)
set-7SET-7. (1611 aa)
NCU02962Uncharacterized protein. (567 aa)
hat-2-2Histone acetyl transferase-2. (1116 aa)
arp-4Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosome [...] (469 aa)
crc-1SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (733 aa)
hel-2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (481 aa)
hel-1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
set-1Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. Belongs to the class V-like SAM-binding methyltransferase superfamily. (1313 aa)
dim-5Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5; Histone methyltransferase that specifically trimethylates histone H3 to form H3K9me3. H3K9me3 marks chromatin regions for DNA methylation. (331 aa)
nop-1rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gl [...] (323 aa)
NCU16790CDC73_C domain-containing protein. (409 aa)
pp-2Protein arginine N-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. (798 aa)
NCU01534PAPA-1 domain-containing protein. (430 aa)
NCU02547Thioredoxin-like_fold domain-containing protein. (276 aa)
NCU02578Paired amphipathic helix protein Sin3a, variant. (1490 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
Server load: low (20%) [HD]