STRINGSTRING
stk-25 stk-25 NCU06091 NCU06091 COQ3 COQ3 COQ7 COQ7 NCU04406 NCU04406 NCU04429 NCU04429 NCU00395 NCU00395 atp23 atp23 NCU00126 NCU00126 apg-1 apg-1 gng-1 gng-1 NCU03947 NCU03947 NCU03817 NCU03817 NCU04281 NCU04281 NCU06719 NCU06719 NCU05119 NCU05119 NCU03438 NCU03438 NCU01814 NCU01814 NCU01444 NCU01444 NCU01445 NCU01445 gna-1 gna-1 gna-2 gna-2 gnb-1 gnb-1 NCU01255 NCU01255 NCU11319 NCU11319 NCU05196 NCU05196 NCU01658 NCU01658 NCU08961 NCU08961 NCU16968 NCU16968 NCU02409 NCU02409 gna-3 gna-3 apg-10 apg-10 apg-2 apg-2 NCU00656 NCU00656 COQ6 COQ6 NCU01922 NCU01922 NCU03029 NCU03029 NCU02725 NCU02725 apg-14 apg-14 NCU02083 NCU02083 coq-4 coq-4 NCU03303 NCU03303 NCU03135 NCU03135 NCU07906 NCU07906 stk-45 stk-45 iml1 iml1 NCU05302 NCU05302 NCU08689 NCU08689 NCU06653 NCU06653 COQ5 COQ5 NCU09865 NCU09865 NCU05837 NCU05837 NCU02305 NCU02305 NCU02359 NCU02359
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
stk-25ABC1 protein. (774 aa)
NCU06091Vacuolar protein sorting-associated protein 74. (349 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (343 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. (256 aa)
NCU04406Vesicle-mediated transporter Vid24. (389 aa)
NCU04429Mitochondrial import protein mmp37. (557 aa)
NCU00395mRNA processing protein. (527 aa)
atp23Mitochondrial inner membrane protease atp23; Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring (By similarity); Belongs to the peptidase M76 family. (293 aa)
NCU00126Erf4 domain-containing protein. (257 aa)
apg-1Serine/threonine-protein kinase apg-1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventin [...] (968 aa)
gng-1Guanine nucleotide-binding protein subunit gamma; Belongs to the G protein gamma family. (93 aa)
NCU03947E3 ubiquitin-protein ligase. (817 aa)
NCU03817FMI1 protein. (398 aa)
NCU04281WD-repeat protein pop3. (318 aa)
NCU06719MSF1 domain-containing protein. (235 aa)
NCU05119Uncharacterized protein. (116 aa)
NCU03438Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (205 aa)
NCU01814Uncharacterized protein. (299 aa)
NCU01444Rheb small monomeric GTPase RhbA. (188 aa)
NCU01445WAPL domain-containing protein. (847 aa)
gna-1Guanine nucleotide-binding protein alpha-1 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. (353 aa)
gna-2Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. (355 aa)
gnb-1Guanine nucleotide-binding protein beta subunit. (358 aa)
NCU01255Mitochondrial dynamin GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (939 aa)
NCU11319Uncharacterized protein. (315 aa)
NCU05196Mitochondrial DnaJ chaperone, variant. (531 aa)
NCU01658WD repeat protein. (1352 aa)
NCU08961Uncharacterized protein. (1047 aa)
NCU16968Cytochrome c mitochondrial import factor. (543 aa)
NCU02409Uncharacterized protein. (892 aa)
gna-3Guanine nucleotide-binding protein alpha-3 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Involved in conidiation; Belongs to the G-alpha family. G(q) subfamily. (356 aa)
apg-10Autophagy-related protein 18; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation- induced autophagy. Involved in correct apg-7/atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). (436 aa)
apg-2Autophagy-related protein 2; Required for cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes completion and peroxisome degradation. Belongs to the ATG2 family. (2051 aa)
NCU00656Phosphatidylinositol 3-kinase VPS34. (914 aa)
COQ6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (490 aa)
NCU01922Uncharacterized protein. (238 aa)
NCU03029Uncharacterized protein. (623 aa)
NCU02725Uncharacterized protein. (984 aa)
apg-14SVP1-like protein 2; Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways. (429 aa)
NCU020831-phosphatidylinositol-3-phosphate 5-kinase. (2558 aa)
coq-4Ubiquinone biosynthesis protein coq-4, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. (347 aa)
NCU03303TUG-UBL1 domain-containing protein. (530 aa)
NCU03135Uncharacterized protein. (204 aa)
NCU07906Methyltransferase. (258 aa)
stk-45Phosphoinositide 3-kinase regulatory subunit 4. (1563 aa)
iml1Vacuolar membrane-associated protein iml1. (2004 aa)
NCU05302GTP-binding protein Obg. (591 aa)
NCU08689Polyphosphoinositide phosphatase Fig4. (1190 aa)
NCU06653Uncharacterized protein. (130 aa)
COQ52-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (341 aa)
NCU09865Methylase. (216 aa)
NCU05837Vacuolar protein sorting-associated protein; May be involved in recycling of membrane proteins between an endocytic compartment and the TGN; Belongs to the VPS13 family. (3209 aa)
NCU02305Probable hexaprenyl pyrophosphate synthase, mitochondrial; Assembly of polyisoprenoid side chains. The polyprenyl synthase of coenzyme Q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species (By similarity); Belongs to the FPP/GGPP synthase family. (449 aa)
NCU02359Uncharacterized protein. (643 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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