(110 nodes) GTPase regulator activity network (Neurospora crassa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NCU10309	TBC domain-containing protein. (776 aa)
	NCU11228	DUF1339 domain-containing protein. (1112 aa)
	NCU11085	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (161 aa)
	NCU10282	Uncharacterized protein; Belongs to the globin family. (2251 aa)
	NCU01539	Vacuolar morphogenesis protein AvaB. (1138 aa)
	cpc-2	Guanine nucleotide-binding protein subunit beta-like protein; Required to activate general amino acid control under conditions of amino acid limitation in the vegetative growth phase, and for formation of protoperithecia in preparation for the sexual phase of the life cycle of N.crassa. (316 aa)
	NCU03330	TBC domain-containing protein. (1137 aa)
	NCU01798	Uncharacterized protein. (889 aa)
	NCU06715	Uncharacterized protein. (1454 aa)
	NCU06668	Uncharacterized protein. (918 aa)
	NCU01150	UBA domain-containing protein 3. (745 aa)
	NCU06774	Intracellular protein transporter. (1089 aa)
	NCU03001	Uncharacterized protein. (552 aa)
	NCU08499	GTPase-activating protein GYP5. (926 aa)
	rdi-1	Rho-gdp dissociation inhibitor. (201 aa)
	NCU03852	GTPase activating protein. (1476 aa)
	NCU01642	Ras-GAP domain-containing protein. (2640 aa)
	NCU00442	Uncharacterized protein. (824 aa)
	NCU00476	UPF0023 family protein. (315 aa)
	NCU04514	GTPase-activating protein gyp3. (1216 aa)
	NCU06500	Cell division control protein 25. (1210 aa)
	NCU01782	Ras guanyl-nucleotide exchange factor RasGEF. (1083 aa)
	NCU00120	Uncharacterized protein. (1237 aa)
	NCU00379	Uncharacterized protein. (671 aa)
	NCU00366	Eukaryotic translation initiation factor 5. (425 aa)
	NCU03890	Stromal membrane-associated protein. (581 aa)
	NCU00283	Uncharacterized protein. (435 aa)
	NCU00233	Glycoside hydrolase. (300 aa)
	NCU07350	AB hydrolase-1 domain-containing protein. (391 aa)
	NCU09537	Rho-GTPase-activating protein 8. (879 aa)
	NCU06875	Uncharacterized protein. (202 aa)
	NCU02347	Sec7 domain-containing protein. (1607 aa)
	NCU02244	C2 domain-containing protein. (592 aa)
	NCU02211	Rab-GAP TBC domain-containing protein. (725 aa)
	apg-7	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machinerie [...] (908 aa)
	NCU02414	Translation initiation factor eif-2b epsilon subunit. (746 aa)
	NCU06035	Elongation factor 1-beta; Belongs to the EF-1-beta/EF-1-delta family. (231 aa)
	NCU02225	Uncharacterized protein. (1631 aa)
	cdc24	Rho guanyl nucleotide exchange factor. (997 aa)
	NCU02259	UDENN FLCN/SMCR8-type domain-containing protein. (523 aa)
	NCU06122	GTPase activating protein Sar1. (780 aa)
	NCU05634	Uncharacterized protein. (1765 aa)
	NCU09781	Uncharacterized protein. (363 aa)
	NCU07061	Uncharacterized protein. (177 aa)
	NCU04789	RanGTP-binding protein. (643 aa)
	NCU05513	Uncharacterized protein. (618 aa)
	NCU05602	Uncharacterized protein. (607 aa)
	NCU05553	Uncharacterized protein. (675 aa)
	NCU08874	Trafficking protein particle complex subunit; Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. (244 aa)
	NCU03661	GTPase-activating protein GYP7. (870 aa)
	NCU04241	TBC1 domain family member 22A. (595 aa)
	NCU07004	TFCD_C domain-containing protein. (1259 aa)
	NCU05272	TBC domain-containing protein. (412 aa)
	bud3	BUD3. (1603 aa)
	NCU07734	Zinc finger protein gcs1. (390 aa)
	NCU08811	Arf GTPase-activating protein. (496 aa)
	NCU08677	Uncharacterized protein. (82 aa)
	NCU05288	Rab GDP dissociation inhibitor; Belongs to the Rab GDI family. (465 aa)
	NCU07274	Uncharacterized protein. (501 aa)
	iml1	Vacuolar membrane-associated protein iml1. (2004 aa)
	NCU06362	GTPase activating protein. (1092 aa)
	NCU08023	Cytohesin-2. (1626 aa)
	NCU07658	Protein transporter sec72. (1940 aa)
	NCU06257	Rab-GAP TBC domain-containing protein. (905 aa)
	NCU07854	Cytosolic regulator Pianissimo. (1547 aa)
	NCU02830	ARF GTPase activator. (1151 aa)
	NCU02120	Uncharacterized protein. (1729 aa)
	ric8	RIC8. (479 aa)
	NCU09812	LIM domain-containing protein. (944 aa)
	Rsp	Round spore. (1017 aa)
	NCU02048	VPS9 domain-containing protein. (1345 aa)
	NCU00563	Uncharacterized protein. (449 aa)
	NCU00553	Rho GTPase activator. (742 aa)
	NCU08379	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (114 aa)
	NCU03237	Mitotic check point protein. (536 aa)
	NCU03207	Ran GTPase activating protein 1. (419 aa)
	NCU03205	Uncharacterized protein. (188 aa)
	NCU03191	Rab proteins geranylgeranyltransferase; Belongs to the Rab GDI family. (490 aa)
	amyc	LIM and Rho-GAP domain-containing protein. (1279 aa)
	NCU01911	GDP/GTP exchange factor Sec2p. (688 aa)
	NCU02938	Uncharacterized protein. (139 aa)
	NCU02524	Rho GAP domain-containing protein. (1464 aa)
	NCU00681	GTPase activating protein. (1182 aa)
	rgf1	Rho guanyl nucleotide exchange factor. (1251 aa)
	get3	ATPase get3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] (339 aa)
	sec23-1	Protein transport protein sec23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (775 aa)
	NCU06435	VPS9 domain-containing protein, variant. (778 aa)
	NCU00196	Rho GTPase activator. (985 aa)
	NCU00443	Ran-specific GTPase-activating protein 1, variant. (250 aa)
	NCU06176	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (187 aa)
	NCU15831	Uncharacterized protein. (847 aa)
	NCU02254	Tubulin folding cofactor C, variant 1. (384 aa)
	NCU09432	SNARE-dependent exocytosis protein, variant. (999 aa)
	NCU01465	Uncharacterized protein. (1500 aa)
	NCU05796	Trafficking protein particle complex subunit BET3. (193 aa)
	NCU08331	Uncharacterized protein. (1008 aa)
	NCU10659	Uncharacterized protein. (340 aa)
	NCU07301	Uncharacterized protein. (752 aa)
	NCU07688	Rho GTPase activator Rga. (1170 aa)
	NCU10647	Rho GTPase activator. (736 aa)
	NCU04105	Rap-GAP domain-containing protein. (1655 aa)
	NCU01659	DDENN domain-containing protein. (1226 aa)
	rgf3	Rho guanyl nucleotide exchange factor. (1744 aa)
	NCU08319	Developmental regulator flbA. (766 aa)
	NCU09758	Ras guanine-nucleotide exchange protein, variant. (1191 aa)
	NCU09492	Uncharacterized protein; Belongs to the DOCK family. (2182 aa)
	NCU16330	Uncharacterized protein. (158 aa)
	NCU03379	Uncharacterized protein. (1820 aa)
	NCU03116	Ras GTPase activating protein, variant 1. (1799 aa)
	NCU01584	Uncharacterized protein. (1012 aa)

Your Current Organism:

Neurospora crassa

NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NCU00120	NCU03237	Q7RYK9	Q7SGT3	Uncharacterized protein.	Mitotic check point protein.	0.899
NCU00120	NCU03330	Q7RYK9	Q1K4P9	Uncharacterized protein.	TBC domain-containing protein.	0.422
NCU00120	NCU03379	Q7RYK9	V5IQW9	Uncharacterized protein.	Uncharacterized protein.	0.617
NCU00120	NCU04514	Q7RYK9	Q7RY49	Uncharacterized protein.	GTPase-activating protein gyp3.	0.422
NCU00196	NCU00553	U9W393	Q7SF96	Rho GTPase activator.	Rho GTPase activator.	0.482
NCU00196	NCU07688	U9W393	V5INV2	Rho GTPase activator.	Rho GTPase activator Rga.	0.764
NCU00196	NCU09537	U9W393	Q7S2C4	Rho GTPase activator.	Rho-GTPase-activating protein 8.	0.437
NCU00196	amyc	U9W393	Q7SH40	Rho GTPase activator.	LIM and Rho-GAP domain-containing protein.	0.493
NCU00196	rgf1	U9W393	Q7SHY5	Rho GTPase activator.	Rho guanyl nucleotide exchange factor.	0.446
NCU00283	NCU00553	Q7RZT1	Q7SF96	Uncharacterized protein.	Rho GTPase activator.	0.502
NCU00366	NCU02414	Q7RYU2	Q7S4E5	Eukaryotic translation initiation factor 5.	Translation initiation factor eif-2b epsilon subunit.	0.716
NCU00366	cpc-2	Q7RYU2	Q01369	Eukaryotic translation initiation factor 5.	Guanine nucleotide-binding protein subunit beta-like protein; Required to activate general amino acid control under conditions of amino acid limitation in the vegetative growth phase, and for formation of protoperithecia in preparation for the sexual phase of the life cycle of N.crassa.	0.918
NCU00379	sec23-1	Q7RYT0	Q9C284	Uncharacterized protein.	Protein transport protein sec23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).	0.868
NCU00442	NCU03001	Q7RXR7	Q1K939	Uncharacterized protein.	Uncharacterized protein.	0.600
NCU00442	NCU03207	Q7RXR7	Q7SGW2	Uncharacterized protein.	Ran GTPase activating protein 1.	0.848
NCU00442	NCU05513	Q7RXR7	Q7S6S6	Uncharacterized protein.	Uncharacterized protein.	0.600
NCU00442	NCU06875	Q7RXR7	Q7S3H8	Uncharacterized protein.	Uncharacterized protein.	0.495
NCU00442	NCU15831	Q7RXR7	U9WGU8	Uncharacterized protein.	Uncharacterized protein.	0.848
NCU00443	NCU03001	U9W553	Q1K939	Ran-specific GTPase-activating protein 1, variant.	Uncharacterized protein.	0.600
NCU00443	NCU03207	U9W553	Q7SGW2	Ran-specific GTPase-activating protein 1, variant.	Ran GTPase activating protein 1.	0.876

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