STRINGSTRING
NCU07519 NCU07519 NCU07395 NCU07395 NCU03337 NCU03337 NCU04749 NCU04749 Prd-6 Prd-6 hel-1 hel-1 hel-2 hel-2 NCU02539 NCU02539 drc-1 drc-1 qde-3 qde-3 mph1 mph1 MCM7 MCM7 atrx atrx NCU08009 NCU08009 mus-51 mus-51 NCU06365 NCU06365 NCU05194 NCU05194 NCU06627 NCU06627 mus-50 mus-50 dbp-9 dbp-9 NCU09793 NCU09793 NCU06049 NCU06049 NCU05756 NCU05756 crf1-1 crf1-1 NCU06438 NCU06438 PIF1 PIF1 NCU01625 NCU01625 mus-52 mus-52 uvs-6 uvs-6 NCU08706 NCU08706 NCU01171 NCU01171 NCU01340 NCU01340 rpa-1 rpa-1 NCU04327 NCU04327 NCU01746 NCU01746 mus-8 mus-8 chl1 chl1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU07519ATP-dependent DNA helicase; Belongs to the helicase family. (813 aa)
NCU07395DNA-binding protein SMUBP-2. (736 aa)
NCU03337ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (483 aa)
NCU04749DNA replication helicase Dna2. (1727 aa)
Prd-6Regulator of nonsense transcripts 1 homolog; Eliminates the production of nonsense-containing RNAs. Belongs to the DNA2/NAM7 helicase family. (1093 aa)
hel-1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
hel-2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (481 aa)
NCU02539DNA helicase; Belongs to the MCM family. (1013 aa)
drc-1DNA replication complex GINS protein psf1; The GINS complex plays an essential role in the initiation of DNA replication. (216 aa)
qde-3RecQ family helicase. (2330 aa)
mph1ATP-dependent DNA helicase mph1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1168 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (824 aa)
atrxATRX. (1869 aa)
NCU08009DNA helicase; Belongs to the MCM family. (944 aa)
mus-51ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (645 aa)
NCU06365DEAD/DEAH box helicase. (1175 aa)
NCU05194DNA helicase; Belongs to the MCM family. (972 aa)
NCU06627Uncharacterized protein. (1190 aa)
mus-50UvrD/REP helicase. (1105 aa)
dbp-9ATP-dependent RNA helicase dbp-9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (676 aa)
NCU09793DEAD/DEAH box DNA helicase. (1563 aa)
NCU06049DNA damage response protein RcaA. (912 aa)
NCU05756Peptidase M4. (449 aa)
crf1-1Helicase swr-1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1845 aa)
NCU06438DNA repair helicase RAD25. (862 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (931 aa)
NCU01625DNA repair helicase RAD3. (806 aa)
mus-52ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (725 aa)
uvs-6UVS6. (1314 aa)
NCU08706AAA family ATPase. (622 aa)
NCU01171DNA helicase; Belongs to the MCM family. (724 aa)
NCU01340Uncharacterized protein. (215 aa)
rpa-1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
NCU04327DNA helicase; Belongs to the MCM family. (882 aa)
NCU01746Uncharacterized protein. (177 aa)
mus-8Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
chl1ATP-dependent DNA helicase chl1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (1068 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
Server load: low (24%) [HD]