STRINGSTRING
NCU10538 NCU10538 NCU10809 NCU10809 NCU01599 NCU01599 NCU03898 NCU03898 cre-1 cre-1 nit-2 nit-2 nmr nmr rco-1 rco-1 ccg-8 ccg-8 NCU03329 NCU03329 tng tng hpo hpo pp-1 pp-1 NCU04597 NCU04597 NCU01377 NCU01377 NCU04325 NCU04325 mrc1 mrc1 NCU01078 NCU01078 sre sre NCU06856 NCU06856 NCU06838 NCU06838 dim-2 dim-2 B5K2.060 B5K2.060 NCU01248 NCU01248 NCU06405 NCU06405 NCU03505 NCU03505 ff-1 ff-1 NCU00159 NCU00159 hda-1 hda-1 NCU00019 NCU00019 NCU00120 NCU00120 vel vel NCU04424 NCU04424 NCU03956 NCU03956 stk-4 stk-4 NCU00363 NCU00363 prk-4 prk-4 NCU07358 NCU07358 nuo14 nuo14 NCU05968 NCU05968 NCU09877 NCU09877 tof-1 tof-1 NCU05945 NCU05945 NCU09130 NCU09130 rad23 rad23 nst-4 nst-4 trf-3 trf-3 NCU04927 NCU04927 rtt-106 rtt-106 msh6 msh6 hat-6 hat-6 NCU04718 NCU04718 NCU07080 NCU07080 NCU07078 NCU07078 nst-1 nst-1 NCU09681 NCU09681 NCU01097 NCU01097 NCU05246 NCU05246 NCU05300 NCU05300 esa-1 esa-1 NCU07679 NCU07679 mus-51 mus-51 atp25 atp25 NCU07975 NCU07975 nst-7 nst-7 NCU07843 NCU07843 nst-3 nst-3 NCU09365 NCU09365 fmf-1 fmf-1 NCU03273 NCU03273 prd-4 prd-4 ada-2 ada-2 NCU00798 NCU00798 csp-1 csp-1 npl4 npl4 csm-3 csm-3 NCU02913 NCU02913 crc-1 crc-1 hH1 hH1 spt-6 spt-6 hh2a hh2a asd-4 asd-4 crf8-1 crf8-1 NCU03965 NCU03965 NCU16966 NCU16966 NCU09866 NCU09866 rcm-1 rcm-1 NCU08049 NCU08049 un-1 un-1 NCU00879 NCU00879 NCU16397 NCU16397 cdp-2 cdp-2 NCU08378 NCU08378 NCU02547 NCU02547 NCU08362 NCU08362 NCU03274 NCU03274 NCU02578 NCU02578
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU10538Clr5 domain-containing protein. (438 aa)
NCU10809Uncharacterized protein. (830 aa)
NCU01599Uncharacterized protein. (570 aa)
NCU03898ESCRT-II complex component. (225 aa)
cre-1DNA-binding protein cre-1; Involved in carbon catabolite repression. Represses the transcription of a number of genes by binding to a GC-rich region in their promoter (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. (430 aa)
nit-2Nitrogen catabolic enzyme regulatory protein; Major nitrogen regulatory protein. During conditions of nitrogen limitation it turns on the expression of genes for enzymes which are required for the use of a variety of secondary nitrogen sources, including nitrates, purines, amino acids, and proteins. (1036 aa)
nmrNitrogen metabolite repression protein nmr; May be a redox sensor protein. Negative transcriptional regulator involved in the post-transcriptional modulation of the GATA- type transcription factor nit-2, forming part of a system controlling nitrogen metabolite repression (By similarity). (488 aa)
rco-1Transcriptional repressor rco-1; Represses transcription by RNA polymerase II. May be involved at several stages of conidiation and other growth and development processes. Appears to regulate genes that are expressed in asexual and sexual spore pathways. (604 aa)
ccg-8Clock-controlled protein 8. (661 aa)
NCU03329Uncharacterized protein. (294 aa)
tngSerine/threonine-protein phosphatase. (388 aa)
hpoHeterochromatin protein 1. (266 aa)
pp-1Transcription factor steA. (722 aa)
NCU04597Repressor of RNA polymerase III transcription MAF1; Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. (391 aa)
NCU01377Anaphase-promoting complex subunit Cut9. (654 aa)
NCU04325Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (760 aa)
mrc1MRC1. (1464 aa)
NCU01078D-mandelate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (442 aa)
sreGATA-type transcription factor sre; GATA-type transcription repressor that regulates iron- acquisition genes through specific binding the GATA sequence elements of target promoters in a zinc-dependent manner. Iron acquisition regulation is critical for survival under both iron-limiting conditions (to acquire essential iron) and iron-replete conditions (to limit iron toxicity). Represses the synthesis of siderophores in high iron conditions. (587 aa)
NCU06856Ubiquitin fusion degradation protein. (382 aa)
NCU06838Uncharacterized protein. (648 aa)
dim-2DNA methyltransferase Dim-2. (1454 aa)
B5K2.060FAS1 domain-containing protein NCU02579. (228 aa)
NCU01248Telo_bind domain-containing protein. (735 aa)
NCU06405DNA polymerase epsilon subunit C. (404 aa)
NCU03505JmjC domain-containing histone demethylation protein 3D. (1977 aa)
ff-1PTAB. (794 aa)
NCU00159Sin3-associated polypeptide Sap18. (264 aa)
hda-1Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (744 aa)
NCU00019FKH1. (688 aa)
NCU00120Uncharacterized protein. (1237 aa)
velNon-specific serine/threonine protein kinase. (833 aa)
NCU04424Uncharacterized protein. (478 aa)
NCU03956Plus3 domain-containing protein. (601 aa)
stk-4Serine/threonine-protein kinase ste20; MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (954 aa)
NCU00363Uncharacterized protein. (761 aa)
prk-4Protein kinase lkh1. (732 aa)
NCU07358Helicase C-terminal domain-containing protein. (1206 aa)
nuo14NADH:ubiquinone oxidoreductase 14kD subunit. (121 aa)
NCU05968Uncharacterized protein. (544 aa)
NCU09877Uncharacterized protein. (424 aa)
tof-1Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with csm-3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1235 aa)
NCU05945Uncharacterized protein. (408 aa)
NCU09130Uncharacterized protein. (693 aa)
rad23Rad23-like protein. (383 aa)
nst-4Hst3p. (1327 aa)
trf-3Transcription elongation factor spt5; The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (1054 aa)
NCU04927Uncharacterized protein. (688 aa)
rtt-106Histone chaperone rtt-106; Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity). (469 aa)
msh6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1246 aa)
hat-6Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1188 aa)
NCU04718DUF1752 domain-containing protein. (573 aa)
NCU07080GFO_IDH_MocA domain-containing protein. (395 aa)
NCU07078Uncharacterized protein. (326 aa)
nst-1Chromatin regulatory protein sir2. (670 aa)
NCU09681Uncharacterized protein. (589 aa)
NCU01097Zn(2)-C6 fungal-type domain-containing protein. (817 aa)
NCU05246DNA repair and recombination protein RAD5C. (1111 aa)
NCU05300WD_REPEATS_REGION domain-containing protein. (685 aa)
esa-1Histone acetyltransferase esa-1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recr [...] (506 aa)
NCU07679Structural maintenance of chromosomes protein. (1179 aa)
mus-51ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (645 aa)
atp25ATPase synthesis protein 25, mitochondrial; Probable mitochondrial mRNA stabilization factor. Belongs to the ATP25 family. (699 aa)
NCU07975DNA repair and recombination protein RAD5B. (950 aa)
nst-7Transcriptional regulator. (373 aa)
NCU07843Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (267 aa)
nst-3SIR2 family histone deacetylase. (647 aa)
NCU09365YTH domain-containing protein. (707 aa)
fmf-1Female and male fertility protein 1. (614 aa)
NCU03273NF-X1 finger transcription factor. (1241 aa)
prd-4Serine/threonine-protein kinase chk2. (702 aa)
ada-2CBF/NF-Y family transcription factor. (138 aa)
NCU00798Uncharacterized protein. (312 aa)
csp-1Conidial separation-1. (287 aa)
npl4Nuclear protein localization protein 4; Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity); Belongs to the NPL4 family. (660 aa)
csm-3Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with tof-1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (409 aa)
NCU02913DNA repair protein rad5. (679 aa)
crc-1SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (733 aa)
hH1Histone H1; Could act as an H1-type linker histone; Belongs to the histone H1/H5 family. (236 aa)
spt-6Transcription elongation factor spt-6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1402 aa)
hh2aHistone H2A; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (134 aa)
asd-4GATA type zinc finger protein asd-4; Transcriptional regulator that functions in sexual development; disruption of asd-4 gene results in agenesis of ascus and ascospore with macroscopically normal fruiting body formation. The GATA-type zinc finger domain binds to DNA sequences from its own promoter region. (426 aa)
crf8-1TBP associated factor, variant. (1893 aa)
NCU03965Catabolite repression protein creC. (643 aa)
NCU16966Uncharacterized protein. (77 aa)
NCU09866Thyroid hormone receptor interactor 12. (2020 aa)
rcm-1RCM-1, variant. (917 aa)
NCU08049Zn(2)-C6 fungal-type domain-containing protein. (991 aa)
un-1Serine/threonine protein kinase. (620 aa)
NCU00879WD domain-containing protein, variant. (352 aa)
NCU16397Nuclear polyadenylated RNA-binding protein Nab2. (522 aa)
cdp-2Chromodomain protein-2, variant. (572 aa)
NCU08378Ubiquitin carboxyl-terminal hydrolase. (849 aa)
NCU02547Thioredoxin-like_fold domain-containing protein. (276 aa)
NCU08362Chromo domain-containing protein. (353 aa)
NCU03274zf-LYAR domain-containing protein. (422 aa)
NCU02578Paired amphipathic helix protein Sin3a, variant. (1490 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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