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NCU00434 NCU00434 vac8 vac8 nmp-1 nmp-1 clu1 clu1 NCU00117 NCU00117 gem-1 gem-1 NCU03937 NCU03937 mdm34 mdm34 NCU00243 NCU00243 NCU00242 NCU00242 NCU07400 NCU07400 tif-6 tif-6 dml-1 dml-1 mrt4 mrt4 NCU06878 NCU06878 NCU05902 NCU05902 NCU09572 NCU09572 NCU02364 NCU02364 NCU06144 NCU06144 nop9 nop9 NCU01276 NCU01276 nmp-2 nmp-2 NCU01199 NCU01199 NCU05259 NCU05259 NCU05233 NCU05233 NCU05282 NCU05282 NCU08811 NCU08811 NCU05289 NCU05289 pod-1 pod-1 kpr-2 kpr-2 NCU06560 NCU06560 sec5 sec5 NCU08312 NCU08312 NCU07984 NCU07984 NCU06268 NCU06268 mdm10 mdm10 NCU07584 NCU07584 NCU06183 NCU06183 NCU09488 NCU09488 NCU05422 NCU05422 NCU03246 NCU03246 NCU03066 NCU03066 NCU03061 NCU03061 NCU08121 NCU08121 NCU09317 NCU09317 NCU02626 NCU02626 NCU09808 NCU09808 myo-1 myo-1 eat-3 eat-3 NCU01971 NCU01971 NCU03263 NCU03263 mdm12 mdm12 cdc5 cdc5 NCU00777 NCU00777 NCU03103 NCU03103 NCU08064 NCU08064 NCU02695 NCU02695 NCU01907 NCU01907 NCU01860 NCU01860 nog-2 nog-2 kpr-1 kpr-1 sec8 sec8 sec16 sec16 mmm-1 mmm-1 pph-3 pph-3 NCU07571 NCU07571 NCU02432 NCU02432 NCU04498 NCU04498 NCU05180 NCU05180 NCU02588 NCU02588 NCU02610 NCU02610 NCU08599 NCU08599 cdc7 cdc7 NCU01539 NCU01539 ro-11 ro-11 tba-1 tba-1 tba-2 tba-2 ro-4 ro-4 ro-1 ro-1 ro-3 ro-3 NCU01575 NCU01575 NCU01644 NCU01644 NCU01809 NCU01809 NCU03438 NCU03438 NCU01510 NCU01510 arp2 arp2 NCU04590 NCU04590 NCU04581 NCU04581 NCU08920 NCU08920 NCU08956 NCU08956 NCU04166 NCU04166 NCU04165 NCU04165 NCU08946 NCU08946 mcl-1 mcl-1 syn-2 syn-2 NCU04124 NCU04124 NCU04119 NCU04119 NCU06777 NCU06777 NCU03009 NCU03009 cen-c cen-c crp-10 crp-10 ran ran hsp70-2 hsp70-2 NCU01820 NCU01820 NCU03562 NCU03562 NCU00493 NCU00493 NCU00209 NCU00209
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU00434Protein phosphatase 2C isoform beta. (619 aa)
vac8Vacuolar protein 8; Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole; Belongs to the beta-catenin family. (559 aa)
nmp-1Nuclear distribution protein nudF-2; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs; Belongs to the WD repeat LIS1/nudF family. (453 aa)
clu1Clustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. (1282 aa)
NCU00117Exocyst complex component SEC15; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (777 aa)
gem-1Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. (629 aa)
NCU03937Intermediate filament protein. (1262 aa)
mdm34Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm-1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. (615 aa)
NCU00243Microtubule-associated protein RP/EB family member 1. (248 aa)
NCU00242V-SNARE. (562 aa)
NCU07400CAP-Gly domain-containing protein. (872 aa)
tif-6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (246 aa)
dml-1Protein dml-1; Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance; Belongs to the misato family. (540 aa)
mrt4Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (252 aa)
NCU06878Uncharacterized protein. (248 aa)
NCU05902Vacuolar assembly protein. (1359 aa)
NCU09572Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (192 aa)
NCU02364C2H2 finger domain-containing protein. (114 aa)
NCU06144Kinesin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1289 aa)
nop9Nucleolar protein 9; RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity); Belongs to the NOP9 family. (775 aa)
NCU01276N-acetyltransferase 5. (190 aa)
nmp-2Nuclear distribution protein nudF-1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs; Belongs to the WD repeat LIS1/nudF family. (486 aa)
NCU01199SNARE domain-containing protein. (259 aa)
NCU05259Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (477 aa)
NCU05233Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (452 aa)
NCU05282Spindle pole body component. (1042 aa)
NCU08811Arf GTPase-activating protein. (496 aa)
NCU05289Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (666 aa)
pod-1Mitochondrion biogenesis protein. (806 aa)
kpr-2Probable kinetochore protein nuf2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (464 aa)
NCU06560HTH APSES-type domain-containing protein. (484 aa)
sec5Exocyst complex component SEC5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (1074 aa)
NCU08312Sec1 family superfamily protein; Belongs to the STXBP/unc-18/SEC1 family. (703 aa)
NCU07984Chromosome segregation protein. (616 aa)
NCU06268Probable vacuolar protein sorting-associated protein 16 homolog; Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. (865 aa)
mdm10Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the recepto [...] (480 aa)
NCU07584Vacuolar segregation protein pep7. (685 aa)
NCU06183Vacuolar protein sorting protein DigA. (973 aa)
NCU09488Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (744 aa)
NCU05422E3 ubiquitin-protein ligase PEP5. (1016 aa)
NCU03246Tyrosine-protein phosphatase CDC14. (654 aa)
NCU03066GTP-binding protein. (550 aa)
NCU03061Translation initiation factor RLI1. (607 aa)
NCU08121Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (200 aa)
NCU09317Uncharacterized protein. (652 aa)
NCU02626Kinesin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1009 aa)
NCU09808Dynamin-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (801 aa)
myo-1Myosin-1; Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1235 aa)
eat-3AMI1 protein. (1988 aa)
NCU01971Uncharacterized protein. (373 aa)
NCU03263Transmembrane protein. (1493 aa)
mdm12Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm-1 subcomplex functions in the major beta-barrel assembly pa [...] (675 aa)
cdc5Serine/threonine protein kinase. (1021 aa)
NCU00777Methyltransferase. (278 aa)
NCU03103Spc7 domain-containing protein. (1483 aa)
NCU08064Meiotically up-regulated 190 protein. (1366 aa)
NCU02695HMG box domain-containing protein. (324 aa)
NCU01907Syntaxin 5. (317 aa)
NCU01860Uncharacterized protein. (543 aa)
nog-2Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (619 aa)
kpr-1Probable kinetochore protein ndc80; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (743 aa)
sec8Probable exocyst complex component sec8; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC8 family. (1111 aa)
sec16COPII coat assembly protein sec16; Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity); Belongs to the SEC16 family. (2084 aa)
mmm-1Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria (By similarity). Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The mdm12-mmm-1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The mdm [...] (415 aa)
pph-3Serine/threonine-protein phosphatase PP1; Belongs to the PPP phosphatase family. PP-1 subfamily. (308 aa)
NCU07571Uncharacterized protein. (322 aa)
NCU02432DnaJ domain-containing protein. (552 aa)
NCU04498Uncharacterized protein. (498 aa)
NCU05180Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (909 aa)
NCU02588Nuclear movement protein nudC, variant 1. (191 aa)
NCU02610Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. (103 aa)
NCU08599Uncharacterized protein. (620 aa)
cdc7Cell cycle protein kinase. (526 aa)
NCU01539Vacuolar morphogenesis protein AvaB. (1138 aa)
ro-11Nuclear distribution protein nudE homolog 1; Required for nuclear migration within hyphae during vegetative growth. (697 aa)
tba-1Tubulin alpha-A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
tba-2Tubulin alpha-B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
ro-4Actin-like protein; Involved in nuclear migration. May function as a component of the dynactin complex which activates force generation by cytoplasmic dynein; Belongs to the actin family. ARP1 subfamily. (380 aa)
ro-1Dynein heavy chain, cytoplasmic; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae; Belongs to the dynein heavy chain family. (4367 aa)
ro-3Dynactin, 150 kDa isoform; Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles (By similarity). (1367 aa)
NCU01575SNARE complex subunit. (292 aa)
NCU01644Intracellular protein transporter UsoA. (1171 aa)
NCU01809AAA family ATPase/60S ribosome export protein Rix7. (884 aa)
NCU03438Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (205 aa)
NCU01510Meiotically up-regulated 190 protein. (1281 aa)
arp2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (395 aa)
NCU04590Uncharacterized protein. (444 aa)
NCU04581Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (835 aa)
NCU08920ATP-binding cassette sub-family F member 2. (613 aa)
NCU08956MSP domain-containing protein. (279 aa)
NCU04166Nucleolar GTP-binding protein 2. (653 aa)
NCU04165Low-temperature viability protein ltv1. (417 aa)
NCU08946Prohibitin. (276 aa)
mcl-1Myosin chain-like-1 protein. (834 aa)
syn-2Syntaxin 2. (335 aa)
NCU04124Golgi membrane protein. (743 aa)
NCU04119SNARE complex subunit; Belongs to the syntaxin family. (362 aa)
NCU06777Syntaxin; Belongs to the syntaxin family. (275 aa)
NCU03009Zuotin. (445 aa)
cen-cCentromere protein C. (755 aa)
crp-10Cytoplasmic ribosomal protein 10; Belongs to the universal ribosomal protein uS3 family. (262 aa)
ranGTP-binding nuclear protein GSP1/Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). (215 aa)
hsp70-2Heat shock protein 70; Belongs to the heat shock protein 70 family. (585 aa)
NCU01820Exportin-1. (1078 aa)
NCU03562Uncharacterized protein. (937 aa)
NCU00493Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (512 aa)
NCU00209Uncharacterized protein. (888 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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