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NCU01821 NCU01821 cys-16 cys-16 NCU08434 NCU08434 met-2 met-2 arg-14 arg-14 NCU01071 NCU01071 NCU03697 NCU03697 trp-2 trp-2 Arg-4 Arg-4 NCU03607 NCU03607 NCU03788 NCU03788 NCU03756 NCU03756 thr-4 thr-4 NCU04292 NCU04292 NCU04303 NCU04303 pro-3 pro-3 met-8 met-8 NCU05093 NCU05093 ilv-4 ilv-4 arg-12 arg-12 NCU03425 NCU03425 pro-1 pro-1 arg-6 arg-6 met-7 met-7 ilv-2 ilv-2 for for leu-1 leu-1 arg-2 arg-2 trp-3 trp-3 trp-1 trp-1 gdh gdh NCU03748 NCU03748 lys-4-2 lys-4-2 pdx-1 pdx-1 arg-8 arg-8 NCU00468 NCU00468 NCU16651 NCU16651 ota ota NCU00409 NCU00409 NCU02450 NCU02450 lys-5 lys-5 gln-2 gln-2 en(am)-2 en(am)-2 NCU17026 NCU17026 NCU06320 NCU06320 NCU07982 NCU07982 arg-1 arg-1 NCU09116 NCU09116 gln-1 gln-1 NCU00581 NCU00581 cys-12 cys-12 NCU02937 NCU02937 arg-3 arg-3 lys-7 lys-7 thr-5 thr-5 lys-4 lys-4 NCU00780 NCU00780 NCU00799 NCU00799 NCU02004 NCU02004 NCU02005 NCU02005 leu-4 leu-4 hom-1 hom-1 mde-1 mde-1 cys-11 cys-11 NCU00536 NCU00536 NCU08117 NCU08117 utr4 utr4 NCU07623 NCU07623 NCU07941 NCU07941 asn-2 asn-2 NCU07725 NCU07725 pyr-3 pyr-3 NCU07690 NCU07690 ilv-6 ilv-6 NCU07115 NCU07115 cbs-2 cbs-2 NCU06117 NCU06117 arg-10 arg-10 mri-1 mri-1 NCU08216 NCU08216 NCU09545 NCU09545 NCU09896 NCU09896 NCU10020 NCU10020 NCU03935 NCU03935 Nic-7 Nic-7 leu-2 leu-2 trp-4 trp-4 cys-17 cys-17 pro-4 pro-4 adi1 adi1 his-7 his-7 ser-7 ser-7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU01821Alanine-glyoxylate aminotransferase. (446 aa)
cys-16Cystathionine gamma-lyase. (417 aa)
NCU084345-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase. (401 aa)
met-2Cystathionine beta-lyase; Involved in de novo synthesis of methionine. Belongs to the trans-sulfuration enzymes family. (457 aa)
arg-14Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. (712 aa)
NCU01071Uncharacterized protein. (388 aa)
NCU03697FAD binding domain-containing protein. (622 aa)
trp-2Anthranilate synthase component I. (582 aa)
Arg-4Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate. (469 aa)
NCU03607Threonine dehydratase catabolic. (388 aa)
NCU03788Cysteine synthase B. (525 aa)
NCU03756Aromatic amino acid aminotransferase 1. (688 aa)
thr-4Homoserine kinase. (358 aa)
NCU04292Branched-chain-amino-acid aminotransferase. (414 aa)
NCU04303Asparagine synthetase 2. (581 aa)
pro-3Gamma-glutamyl phosphate reductase. (445 aa)
met-8Methionine synthase. (769 aa)
NCU05093Cystathionine gamma-synthase. (657 aa)
ilv-4Acetolactate synthase small subunit. (330 aa)
arg-12Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (385 aa)
NCU03425Threonine synthase. (553 aa)
pro-1Pyrroline-5-carboxylate reductase. (332 aa)
arg-6N-acetyl-gamma-glutamyl-phosphate reductase; In the N-terminal section; belongs to the acetylglutamate kinase family. (871 aa)
met-7Cystathionine gamma-synthase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity). (621 aa)
ilv-2Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family. (402 aa)
forSerine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. (480 aa)
leu-13-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (368 aa)
arg-2Carbamoyl-phosphate synthase arginine-specific small chain, mitochondrial. (453 aa)
trp-3Tryptophan synthase; In the C-terminal section; belongs to the TrpB family. (708 aa)
trp-1Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities. (762 aa)
gdhNADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (454 aa)
NCU03748Saccharopine dehydrogenase. (448 aa)
lys-4-2Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. (784 aa)
pdx-1Probable pyridoxal 5'-phosphate synthase subunit pdx-1; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by pdx-2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme- catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers. (308 aa)
arg-8Acetylornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa)
NCU00468Prephenate dehydrogenase [NADP(+)]; Belongs to the prephenate/arogenate dehydrogenase family. (445 aa)
NCU16651Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. (241 aa)
otaOrnithine aminotransferase. (452 aa)
NCU00409Chorismate mutase/prephenate dehydratase, variant. (388 aa)
NCU02450Threonine dehydratase. (584 aa)
lys-5Homocitrate synthase, variant 1; Belongs to the alpha-IPM synthase/homocitrate synthase family. (425 aa)
gln-2Glutamine synthetase. (394 aa)
en(am)-2Glutamate synthase, variant. (2116 aa)
NCU17026HET domain-containing protein. (153 aa)
NCU06320Uncharacterized protein. (687 aa)
NCU07982Acetolactate synthase. (689 aa)
arg-1Argininosuccinate synthase. (417 aa)
NCU09116Aromatic aminotransferase Aro8, variant. (560 aa)
gln-1Glutamine synthetase. (362 aa)
NCU00581Phosphopantetheinyl transferase. (348 aa)
cys-12Cysteine synthase 2; Putative cysteine synthase that catalyzes the conversion of O-acetyl-L-serine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway. However, in contrast to cysteine synthase cys-17, this CS-like protein may not function in cysteine biosynthesis. (456 aa)
NCU02937Uncharacterized protein. (203 aa)
arg-3Carbamoyl-phosphate synthase large subunit. (1168 aa)
lys-7Homoisocitrate dehydrogenase. (402 aa)
thr-5L-allo-threonine aldolase. (470 aa)
lys-4Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Catalyzes the NAD(+)-dependent cleavage of saccharopine to L- lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis; Belongs to the AlaDH/PNT family. (372 aa)
NCU00780D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (363 aa)
NCU00799Homocysteine S-methyltransferase. (361 aa)
NCU02004Phosphoserine phosphatase. (496 aa)
NCU02005Phosphoadenosine phosphosulfate reductase. (398 aa)
leu-42-isopropylmalate synthase. (625 aa)
hom-1Aspartate-semialdehyde dehydrogenase. (362 aa)
mde-1Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). (258 aa)
cys-11Sulfate adenylyltransferase; Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. In the C-terminal section; belongs to the APS kinase family. (573 aa)
NCU00536Homoserine O-acetyltransferase. (525 aa)
NCU08117Uncharacterized protein. (675 aa)
utr4Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (234 aa)
NCU076232,2-dialkylglycine decarboxylase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (535 aa)
NCU07941Aspartate aminotransferase. (482 aa)
asn-2Asparagine synthetase domain-containing protein 1. (597 aa)
NCU07725Chorismate mutase. (269 aa)
pyr-3PyrABCN. (1832 aa)
NCU07690Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (613 aa)
ilv-6Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (405 aa)
NCU07115HET domain-containing protein. (622 aa)
cbs-2Putative serine hydroxymethyltransferase, mitochondrial; Interconversion of serine and glycine. (546 aa)
NCU06117Uncharacterized protein. (595 aa)
arg-10Argininosuccinate lyase. (466 aa)
mri-1Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (388 aa)
NCU08216Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (528 aa)
NCU09545Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (681 aa)
NCU09896Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (211 aa)
NCU10020Methionine synthase. (385 aa)
NCU03935Homoserine dehydrogenase. (365 aa)
Nic-7S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (310 aa)
leu-23-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (779 aa)
trp-4Anthranilate phosphoribosyltransferase. (436 aa)
cys-17Cysteine synthase 1; Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine; Belongs to the cysteine synthase/cystathionine beta- synthase family. (376 aa)
pro-4Glutamate 5-kinase. (468 aa)
adi11,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (178 aa)
his-71-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (257 aa)
ser-7Phosphoserine aminotransferase. (429 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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