STRINGSTRING
NCU09439 NCU09439 mus-9 mus-9 msh4 msh4 NCU10651 NCU10651 NCU10400 NCU10400 cdc7 cdc7 NCU01771 NCU01771 NCU03905 NCU03905 mus-8 mus-8 tbg tbg chs-4 chs-4 arp2 arp2 NCU04590 NCU04590 NCU04581 NCU04581 NCU04604 NCU04604 NCU04665 NCU04665 mcl-1 mcl-1 spo11 spo11 syn-2 syn-2 NCU03629 NCU03629 rpa-1 rpa-1 NCU01344 NCU01344 NCU03714 NCU03714 NCU01058 NCU01058 NCU05385 NCU05385 mei-3 mei-3 cen-c cen-c NCU03517 NCU03517 NCU00424 NCU00424 mus-25 mus-25 hpth-1 hpth-1 uvs-6 uvs-6 mus-38 mus-38 NCU00081 NCU00081 NCU00205 NCU00205 NCU00399 NCU00399 NCU06463 NCU06463 hcp-1 hcp-1 NCU03956 NCU03956 NCU03955 NCU03955 NCU06935 NCU06935 NCU09297 NCU09297 NCU09715 NCU09715 msh6 msh6 NCU05756 NCU05756 NCU06049 NCU06049 mss4 mss4 NCU02263 NCU02263 NCU09793 NCU09793 mus-44 mus-44 NCU03786 NCU03786 NCU08806 NCU08806 NCU06401 NCU06401 kpr-2 kpr-2 NCU06560 NCU06560 NCU07699 NCU07699 NCU06342 NCU06342 NCU08039 NCU08039 pms-1 pms-1 NCU07984 NCU07984 NCU07870 NCU07870 NCU03246 NCU03246 mlh-2 mlh-2 mus-81 mus-81 polh polh eat-3 eat-3 NCU01971 NCU01971 NCU09742 NCU09742 NCU07442 NCU07442 cdc5 cdc5 NCU01989 NCU01989 NCU03190 NCU03190 NCU02540 NCU02540 sgo-1 sgo-1 mus-23 mus-23 NCU07571 NCU07571 NCU00401 NCU00401 NCU16699 NCU16699 NCU08875 NCU08875 NCU03820 NCU03820 NCU06338 NCU06338 mlh-1 mlh-1 ck-1a ck-1a NCU10788 NCU10788 NCU16423 NCU16423 NCU16422 NCU16422 NCU02610 NCU02610 NCU10030 NCU10030
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU09439RecQ mediated genome instability protein Rmi1. (284 aa)
mus-9Phosphatidyl inositol 3-kinase; Belongs to the PI3/PI4-kinase family. (2492 aa)
msh4MutS ortholog 4 protein. (1318 aa)
NCU10651Chitin binding protein. (396 aa)
NCU10400Phospholipase. (912 aa)
cdc7Cell cycle protein kinase. (526 aa)
NCU01771DNA repair protein rhp57. (510 aa)
NCU03905BZIP domain-containing protein. (577 aa)
mus-8Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
tbgTubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. (461 aa)
chs-4Chitin synthase 4; Belongs to the chitin synthase family. Class IV subfamily. (1235 aa)
arp2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (395 aa)
NCU04590Uncharacterized protein. (444 aa)
NCU04581Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (835 aa)
NCU04604Uncharacterized protein. (548 aa)
NCU04665Uncharacterized protein. (235 aa)
mcl-1Myosin chain-like-1 protein. (834 aa)
spo11Meiosis-specific topoisomerase Spo11. (466 aa)
syn-2Syntaxin 2. (335 aa)
NCU03629Uncharacterized protein. (112 aa)
rpa-1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
NCU01344Uncharacterized protein. (532 aa)
NCU03714Thioredoxin. (580 aa)
NCU01058Uncharacterized protein. (604 aa)
NCU05385MutL_C domain-containing protein. (937 aa)
mei-3DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (353 aa)
cen-cCentromere protein C. (755 aa)
NCU03517Ski8. (342 aa)
NCU00424Spo76 protein. (1595 aa)
mus-25DNA repair and recombination protein RAD54. (835 aa)
hpth-1Ubiquitin ligase complex F-box protein GRR1. (800 aa)
uvs-6UVS6. (1314 aa)
mus-38MUS38. (960 aa)
NCU00081DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (695 aa)
NCU00205Peptidase C50 domain-containing protein. (2185 aa)
NCU00399Cell wall protein PhiA. (198 aa)
NCU06463Uncharacterized protein. (509 aa)
hcp-1Two-component system protein A. (925 aa)
NCU03956Plus3 domain-containing protein. (601 aa)
NCU03955Phospholipase. (1885 aa)
NCU06935Integrase_H2C2 domain-containing protein. (1347 aa)
NCU09297Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1249 aa)
NCU09715Trehalose-6-phosphate synthase. (523 aa)
msh6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1246 aa)
NCU05756Peptidase M4. (449 aa)
NCU06049DNA damage response protein RcaA. (912 aa)
mss4Phosphatidylinositol-4-phosphate 5-kinase its3. (1012 aa)
NCU02263Sec14 cytosolic factor. (334 aa)
NCU09793DEAD/DEAH box DNA helicase. (1563 aa)
mus-44Mating-type switching protein swi10. (405 aa)
NCU03786Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (670 aa)
NCU08806RECA_2 domain-containing protein. (442 aa)
NCU06401Uncharacterized protein. (241 aa)
kpr-2Probable kinetochore protein nuf2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (464 aa)
NCU06560HTH APSES-type domain-containing protein. (484 aa)
NCU07699Uncharacterized protein. (793 aa)
NCU06342Phospholipase. (978 aa)
NCU08039RING-type domain-containing protein. (359 aa)
pms-1DNA mismatch repair protein. (1157 aa)
NCU07984Chromosome segregation protein. (616 aa)
NCU07870DNA polymerase. (1479 aa)
NCU03246Tyrosine-protein phosphatase CDC14. (654 aa)
mlh-2MUTL-2. (772 aa)
mus-81Crossover junction endonuclease mus-81; Interacts with eme-1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (645 aa)
polhSister chromatid cohesion protein Eso1. (672 aa)
eat-3AMI1 protein. (1988 aa)
NCU01971Uncharacterized protein. (373 aa)
NCU09742Sporulation-specific protein. (552 aa)
NCU07442Betaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (606 aa)
cdc5Serine/threonine protein kinase. (1021 aa)
NCU01989Uncharacterized protein. (288 aa)
NCU03190Rec8. (763 aa)
NCU02540Meiotic expression up-regulated protein 14. (339 aa)
sgo-1Shugoshin; Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms; Belongs to the shugoshin family. (774 aa)
mus-23Double-strand break repair protein mus-23; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity); Belongs to the MRE11/RAD32 family. (739 aa)
NCU07571Uncharacterized protein. (322 aa)
NCU00401Uncharacterized protein. (458 aa)
NCU16699PIPK domain-containing protein. (401 aa)
NCU08875Cullin binding protein CanA, variant 1. (1348 aa)
NCU03820Checkpoint protein; Belongs to the HUS1 family. (371 aa)
NCU06338DNA topoisomerase 2. (1994 aa)
mlh-1DNA mismatch repair protein mutL, variant. (751 aa)
ck-1aCasein kinase I isoform delta; Belongs to the protein kinase superfamily. (384 aa)
NCU10788Uncharacterized protein. (386 aa)
NCU16423Uncharacterized protein. (378 aa)
NCU16422Uncharacterized protein. (79 aa)
NCU02610Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. (103 aa)
NCU10030Alpha-L-rhamnosidase C, variant. (822 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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