STRINGSTRING
B5K2.060 B5K2.060 NCU01362 NCU01362 NCU08934 NCU08934 set-2 set-2 NCU09496 NCU09496 NCU07554 NCU07554 gpr-2 gpr-2 NCU07364 NCU07364 NCU01410 NCU01410 NCU02750 NCU02750 NCU08068 NCU08068 NCU03190 NCU03190 NCU02965 NCU02965 NCU02683 NCU02683 csm-3 csm-3 arp-4 arp-4 NCU02531 NCU02531 NCU00694 NCU00694 crc-1 crc-1 crf2-1 crf2-1 hel-2 hel-2 hH1 hH1 5F3.150 5F3.150 hel-1 hel-1 ctc-2 ctc-2 slx1 slx1 NCU06503 NCU06503 NCU00470 NCU00470 crf8-1 crf8-1 NCU00244 NCU00244 NCU07571 NCU07571 NCU15832 NCU15832 qde-2 qde-2 NCU03820 NCU03820 NCU16971 NCU16971 NCU10346 NCU10346 NCU08700 NCU08700 NCU01534 NCU01534 NCU03070 NCU03070 NCU10788 NCU10788 NCU02547 NCU02547 NCU10376 NCU10376 NCU16423 NCU16423 NCU02121 NCU02121 NCU02578 NCU02578 NCU16496 NCU16496 NCU03064 NCU03064 NCU07395 NCU07395 rpa-3 rpa-3 NCU10232 NCU10232 sms-2 sms-2 NCU03572 NCU03572 NCU04548 NCU04548 NCU00424 NCU00424 NCU09221 NCU09221 NCU03101 NCU03101 NCU09078 NCU09078 slx4 slx4 NCU00897 NCU00897 NCU00941 NCU00941 NCU09261 NCU09261 NCU02078 NCU02078 hda-2 hda-2 NCU00729 NCU00729 NCU00730 NCU00730 hda-3 hda-3 NCU03291 NCU03291 NCU03073 NCU03073 drc-1 drc-1 NCU09388 NCU09388 NCU09365 NCU09365 NCU02086 NCU02086 eaf-1 eaf-1 NCU07870 NCU07870 arp-8 arp-8 NCU07878 NCU07878 NCU07998 NCU07998 NCU08003 NCU08003 NCU08022 NCU08022 NCU08039 NCU08039 drc-2 drc-2 NCU08317 NCU08317 NCU07313 NCU07313 NCU06623 NCU06623 arp-5 arp-5 NCU06395 NCU06395 NCU07290 NCU07290 NCU08840 NCU08840 rpa-2 rpa-2 NCU05280 NCU05280 NCU07893 NCU07893 NCU07896 NCU07896 NCU08688 NCU08688 hat-2 hat-2 NCU03461 NCU03461 NCU03564 NCU03564 ctc-1 ctc-1 NCU05040 NCU05040 NCU00070 NCU00070 crf4-1 crf4-1 crf4-2 crf4-2 NCU00444 NCU00444 NCU00423 NCU00423 snf5 snf5 hda-1 hda-1 crc-2 crc-2 NCU06838 NCU06838 NCU06787 NCU06787 mei-3 mei-3 NCU00345 NCU00345 yaf9 yaf9 NCU03892 NCU03892 set-4 set-4 NCU04412 NCU04412 NCU04413 NCU04413 NCU06463 NCU06463 NCU00412 NCU00412 NCU00118 NCU00118 crf7-1 crf7-1 arp-6 arp-6 NCU05530 NCU05530 NCU04848 NCU04848 NCU04738 NCU04738 NCU04741 NCU04741 NCU09793 NCU09793 NCU05891 NCU05891 pbd-1 pbd-1 NCU08169 NCU08169 NCU02221 NCU02221 NCU02232 NCU02232 drc-3 drc-3 NCU06878 NCU06878 NCU06928 NCU06928 NCU09130 NCU09130 tof-1 tof-1 NCU09877 NCU09877 NCU05979 NCU05979 NCU07568 NCU07568 NCU05968 NCU05968 crf1-1 crf1-1 NCU10155 NCU10155 NCU05909 NCU05909 NCU06866 NCU06866 asa-1 asa-1 NCU10897 NCU10897 stk-52 stk-52 NCU06788 NCU06788 NCU01599 NCU01599 NCU01799 NCU01799 NCU01841 NCU01841 NCU03528 NCU03528 crf3-1 crf3-1 NCU03405 NCU03405 NCU07157 NCU07157 NCU05433 NCU05433 pold-1 pold-1 NCU01344 NCU01344 NCU03597 NCU03597 rpa-1 rpa-1 NCU03792 NCU03792 NCU03763 NCU03763 NCU06696 NCU06696 mrc1 mrc1 NCU01370 NCU01370
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
B5K2.060FAS1 domain-containing protein NCU02579. (228 aa)
NCU01362INO80 chromatin remodeling complex. (750 aa)
NCU08934Uncharacterized protein. (349 aa)
set-2Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that trimethylates histone H3 'Lys- 36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (954 aa)
NCU09496C2H2 transcription factor. (1159 aa)
NCU07554Structural maintenance of chromosomes protein. (1204 aa)
gpr-2G-protein coupled receptor. (484 aa)
NCU07364Uncharacterized protein. (381 aa)
NCU01410DUF1711 domain-containing protein. (291 aa)
NCU02750PH domain-containing protein. (1319 aa)
NCU08068Mitotic spindle biogenesis protein Spc19. (194 aa)
NCU03190Rec8. (763 aa)
NCU02965Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (766 aa)
NCU02683Uncharacterized protein. (738 aa)
csm-3Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with tof-1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (409 aa)
arp-4Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosome [...] (469 aa)
NCU02531Telomere_reg-2 domain-containing protein. (922 aa)
NCU00694Uncharacterized protein. (708 aa)
crc-1SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (733 aa)
crf2-1Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1997 aa)
hel-2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (481 aa)
hH1Histone H1; Could act as an H1-type linker histone; Belongs to the histone H1/H5 family. (236 aa)
5F3.150Probable DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (513 aa)
hel-1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
ctc-2FACT complex subunit ctc-2; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1032 aa)
slx1Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (402 aa)
NCU06503C2H2 finger domain-containing protein. (808 aa)
NCU00470DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (484 aa)
crf8-1TBP associated factor, variant. (1893 aa)
NCU00244Glycosyl transferase, variant. (311 aa)
NCU07571Uncharacterized protein. (322 aa)
NCU15832Cytochrome b561 domain-containing protein. (877 aa)
qde-2Post-transcriptional silencing protein QDE-2. (1089 aa)
NCU03820Checkpoint protein; Belongs to the HUS1 family. (371 aa)
NCU16971Uncharacterized protein. (236 aa)
NCU10346Uncharacterized protein. (2592 aa)
NCU08700Uncharacterized protein. (1043 aa)
NCU01534PAPA-1 domain-containing protein. (430 aa)
NCU03070Homeobox domain-containing protein. (653 aa)
NCU10788Uncharacterized protein. (386 aa)
NCU02547Thioredoxin-like_fold domain-containing protein. (276 aa)
NCU10376Uncharacterized protein. (441 aa)
NCU16423Uncharacterized protein. (378 aa)
NCU02121Transcriptional regulator. (633 aa)
NCU02578Paired amphipathic helix protein Sin3a, variant. (1490 aa)
NCU16496NUDIX family hydrolase. (461 aa)
NCU03064RSC complex subunit Rsc7. (648 aa)
NCU07395DNA-binding protein SMUBP-2. (736 aa)
rpa-3Replication protein A-3. (108 aa)
NCU10232Uncharacterized protein. (557 aa)
sms-2Meiotic silencing suppressor 2; Belongs to the argonaute family. (989 aa)
NCU03572SWI-SNF complex subunit. (570 aa)
NCU04548DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2259 aa)
NCU00424Spo76 protein. (1595 aa)
NCU09221HIT finger domain-containing protein. (373 aa)
NCU03101Uncharacterized protein. (716 aa)
NCU09078Uncharacterized protein. (156 aa)
slx4Structure-specific endonuclease subunit slx4; Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (1013 aa)
NCU00897Sin3 complex subunit. (924 aa)
NCU00941Uncharacterized protein. (1048 aa)
NCU09261DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (221 aa)
NCU02078Uncharacterized protein. (713 aa)
hda-2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (499 aa)
NCU00729Uncharacterized protein. (251 aa)
NCU00730Fungal_trans domain-containing protein. (904 aa)
hda-3Histone deacetylase RPD3. (658 aa)
NCU03291Double-strand-break repair protein rad21. (658 aa)
NCU03073CBFD_NFYB_HMF domain-containing protein. (397 aa)
drc-1DNA replication complex GINS protein psf1; The GINS complex plays an essential role in the initiation of DNA replication. (216 aa)
NCU09388PHD domain-containing protein. (789 aa)
NCU09365YTH domain-containing protein. (707 aa)
NCU02086Uncharacterized protein. (562 aa)
eaf-1Chromatin modification-related protein eaf-1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (2189 aa)
NCU07870DNA polymerase. (1479 aa)
arp-8Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (748 aa)
NCU07878RRM domain-containing protein. (356 aa)
NCU07998Uncharacterized protein. (441 aa)
NCU08003RSC complex subunit. (690 aa)
NCU08022Poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (619 aa)
NCU08039RING-type domain-containing protein. (359 aa)
drc-2DNA replication complex GINS protein psf2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (273 aa)
NCU08317PHD-type domain-containing protein. (1021 aa)
NCU07313Chromosome transmission fidelity protein 18. (997 aa)
NCU06623CBFD_NFYB_HMF domain-containing protein. (304 aa)
arp-5Chromatin remodeling complex subunit; Belongs to the actin family. (762 aa)
NCU06395YL1_C domain-containing protein. (210 aa)
NCU07290Nuclear localization protein. (527 aa)
NCU08840Chromatin remodeling complex subunit; Belongs to the actin family. (751 aa)
rpa-2Replication protein A-2. (284 aa)
NCU05280Uncharacterized protein. (487 aa)
NCU07893RSC complex subunit Sfh1. (591 aa)
NCU07896Uncharacterized protein. (739 aa)
NCU08688Uncharacterized protein. (592 aa)
hat-2Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. (446 aa)
NCU03461Chromatin modification-related protein. (824 aa)
NCU03564Flap structure-specific endonuclease. (1037 aa)
ctc-1FACT complex subunit ctc-1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (565 aa)
NCU05040GFA domain-containing protein. (297 aa)
NCU00070PHD-type domain-containing protein. (888 aa)
crf4-1Chromatin remodelling complex ATPase chain ISW1. (1126 aa)
crf4-2DDT domain-containing protein. (1092 aa)
NCU00444Transcription initiation factor TFIID subunit 14. (226 aa)
NCU00423PHD-type domain-containing protein. (1413 aa)
snf5SWI-SNF complex subunit. (732 aa)
hda-1Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (744 aa)
crc-2SWR1-complex protein 5; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (342 aa)
NCU06838Uncharacterized protein. (648 aa)
NCU06787MRG domain-containing protein. (366 aa)
mei-3DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (353 aa)
NCU00345Uncharacterized protein. (1125 aa)
yaf9Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (309 aa)
NCU03892Uncharacterized protein. (1043 aa)
set-4SET-4. (948 aa)
NCU04412Uncharacterized protein. (347 aa)
NCU04413UPF0132 domain-containing protein. (239 aa)
NCU06463Uncharacterized protein. (509 aa)
NCU00412WHIM1 domain-containing protein. (663 aa)
NCU00118RRM domain-containing protein. (713 aa)
crf7-1Chromodomain-helicase-DNA-binding protein 4. (1726 aa)
arp-6Actin-related protein 6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (446 aa)
NCU05530Chromo domain-containing protein. (336 aa)
NCU04848Uncharacterized protein. (929 aa)
NCU04738Zf-primase domain-containing protein. (977 aa)
NCU04741Uncharacterized protein. (324 aa)
NCU09793DEAD/DEAH box DNA helicase. (1563 aa)
NCU05891Arid/bright domain-containing protein. (1289 aa)
pbd-1RSC complex subunit. (1206 aa)
NCU08169Uncharacterized protein. (208 aa)
NCU02221Uncharacterized protein. (253 aa)
NCU02232DNA primase; Belongs to the eukaryotic-type primase small subunit family. (576 aa)
drc-3DNA replication complex GINS protein psf3; The GINS complex plays an essential role in the initiation of DNA replication. (218 aa)
NCU06878Uncharacterized protein. (248 aa)
NCU06928Uncharacterized protein. (853 aa)
NCU09130Uncharacterized protein. (693 aa)
tof-1Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with csm-3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1235 aa)
NCU09877Uncharacterized protein. (424 aa)
NCU05979RXT2_N domain-containing protein. (580 aa)
NCU07568HMG box domain-containing protein. (353 aa)
NCU05968Uncharacterized protein. (544 aa)
crf1-1Helicase swr-1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1845 aa)
NCU10155DNA polymerase epsilon subunit B. (851 aa)
NCU05909Uncharacterized protein. (503 aa)
NCU06866Asparaginyl-tRNA synthetase. (604 aa)
asa-1ASTRA-associated protein 1; Component of the ASTRA complex involved in chromatin remodeling. (485 aa)
NCU10897Uncharacterized protein. (72 aa)
stk-52Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (543 aa)
NCU06788Chromo domain-containing protein. (145 aa)
NCU01599Uncharacterized protein. (570 aa)
NCU01799Uncharacterized protein. (119 aa)
NCU01841Uncharacterized protein. (130 aa)
NCU03528DNA polymerase delta subunit 4. (241 aa)
crf3-1SNF2-family ATP dependent chromatin remodeling factor snf21. (1482 aa)
NCU03405Uncharacterized protein. (137 aa)
NCU07157TFIIIC_sub6 domain-containing protein. (464 aa)
NCU05433Uncharacterized protein. (412 aa)
pold-1DNA polymerase. (1104 aa)
NCU01344Uncharacterized protein. (532 aa)
NCU03597DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (667 aa)
rpa-1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
NCU03792Inositol polyphosphate phosphatase. (1206 aa)
NCU03763DNA polymerase delta subunit 2. (525 aa)
NCU06696Chromo domain-containing protein. (1464 aa)
mrc1MRC1. (1464 aa)
NCU01370Uncharacterized protein. (603 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
Server load: medium (44%) [HD]