STRINGSTRING
mus-9 mus-9 NCU09466 NCU09466 NCU06222 NCU06222 stk-5 stk-5 NCU05726 NCU05726 NCU06269 NCU06269 mus-53 mus-53 nst-7 nst-7 NCU07998 NCU07998 NCU06345 NCU06345 NCU06547 NCU06547 esa-1 esa-1 NCU07293 NCU07293 NCU08806 NCU08806 parp parp mus-81 mus-81 qde-3 qde-3 ham-4 ham-4 ptk-2 ptk-2 NCU02187 NCU02187 prd-4 prd-4 NCU09085 NCU09085 NCU00800 NCU00800 csm-3 csm-3 stk-20 stk-20 mus-23 mus-23 mus-11 mus-11 slx1 slx1 NCU00124 NCU00124 NCU17268 NCU17268 NCU08955 NCU08955 NCU03486 NCU03486 un-1 un-1 NCU03337 NCU03337 NCU08637 NCU08637 mus-59 mus-59 NCU04847 NCU04847 NCU06049 NCU06049 tof-1 tof-1 NCU09439 NCU09439 NCU05966 NCU05966 NCU09503 NCU09503 NCU09288 NCU09288 fi fi mus-21 mus-21 NCU04058 NCU04058 NCU06457 NCU06457 crf4-1 crf4-1 NCU00081 NCU00081 stk-30 stk-30 NCU03564 NCU03564 uvs-6 uvs-6 pp4 pp4 NCU03765 NCU03765 mei-3 mei-3 pp2A pp2A NCU01321 NCU01321 rpa-1 rpa-1 NCU01365 NCU01365 NCU03924 NCU03924 NCU03528 NCU03528 NCU08772 NCU08772 preg preg hh2b hh2b ubi::crp-6 ubi::crp-6 ubi ubi NCU01771 NCU01771
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mus-9Phosphatidyl inositol 3-kinase; Belongs to the PI3/PI4-kinase family. (2492 aa)
NCU09466Uncharacterized protein. (553 aa)
NCU06222Tyrosyl-DNA phosphodiesterase domain-containing protein. (691 aa)
stk-5Serine/threonine-protein kinase hal4; Belongs to the protein kinase superfamily. (497 aa)
NCU05726Mucin. (785 aa)
NCU06269FHA domain-containing protein. (790 aa)
mus-53DNA ligase 4; Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining; Belongs to the ATP-dependent DNA ligase family. (1050 aa)
nst-7Transcriptional regulator. (373 aa)
NCU07998Uncharacterized protein. (441 aa)
NCU06345Tyrosyl-DNA phosphodiesterase. (661 aa)
NCU06547Uncharacterized protein. (624 aa)
esa-1Histone acetyltransferase esa-1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recr [...] (506 aa)
NCU07293Uncharacterized protein. (339 aa)
NCU08806RECA_2 domain-containing protein. (442 aa)
parpPoly [ADP-ribose] polymerase. (670 aa)
mus-81Crossover junction endonuclease mus-81; Interacts with eme-1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (645 aa)
qde-3RecQ family helicase. (2330 aa)
ham-4FHA domain-containing protein. (797 aa)
ptk-2Serine/threonine protein kinase. (713 aa)
NCU02187Uncharacterized protein. (291 aa)
prd-4Serine/threonine-protein kinase chk2. (702 aa)
NCU09085Cyclin. (672 aa)
NCU00800Protein kinase domain-containing protein. (756 aa)
csm-3Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with tof-1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (409 aa)
stk-20Serine/threonine protein kinase-20. (602 aa)
mus-23Double-strand break repair protein mus-23; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity); Belongs to the MRE11/RAD32 family. (739 aa)
mus-11DNA repair and recombination protein mus-11; Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the mei-3/rad51 recombinase (By similarity). (600 aa)
slx1Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (402 aa)
NCU00124Uncharacterized protein. (1568 aa)
NCU17268Uncharacterized protein. (286 aa)
NCU08955UBX domain-containing protein, variant. (317 aa)
NCU03486C3H1-type domain-containing protein. (488 aa)
un-1Serine/threonine protein kinase. (620 aa)
NCU03337ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (483 aa)
NCU08637Uncharacterized protein. (513 aa)
mus-59Serine/threonine-protein kinase. (1233 aa)
NCU04847Cyclin. (393 aa)
NCU06049DNA damage response protein RcaA. (912 aa)
tof-1Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with csm-3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1235 aa)
NCU09439RecQ mediated genome instability protein Rmi1. (284 aa)
NCU05966DNA repair protein. (603 aa)
NCU09503Uncharacterized protein. (1048 aa)
NCU09288Uncharacterized protein. (662 aa)
fiProtein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
mus-21Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2939 aa)
NCU04058BZIP domain-containing protein. (306 aa)
NCU06457Asparaginyl-tRNA synthetase. (580 aa)
crf4-1Chromatin remodelling complex ATPase chain ISW1. (1126 aa)
NCU00081DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (695 aa)
stk-30Protein kinase. (757 aa)
NCU03564Flap structure-specific endonuclease. (1037 aa)
uvs-6UVS6. (1314 aa)
pp4Serine/threonine-protein phosphatase. (423 aa)
NCU037653'-5' exonuclease/helicase. (753 aa)
mei-3DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (353 aa)
pp2ASerine/threonine-protein phosphatase. (320 aa)
NCU01321DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (602 aa)
rpa-1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
NCU01365ATP dependent DNA ligase domain-containing protein. (1072 aa)
NCU03924DNA repair protein Rtt107. (847 aa)
NCU03528DNA polymerase delta subunit 4. (241 aa)
NCU08772Cyclin-dependent protein kinase complex component. (369 aa)
pregNuc-1 negative regulatory protein preg; Negative regulator, together with pgov, of the transcriptional activator nuc-1, which controls the expression of phosphorous acquisition enzymes. (483 aa)
hh2bHistone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (137 aa)
ubi::crp-6Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (154 aa)
ubiPolyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys [...] (305 aa)
NCU01771DNA repair protein rhp57. (510 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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