STRINGSTRING
ubi ubi ubi::crp-6 ubi::crp-6 hh2b hh2b uvs-6 uvs-6 crf4-1 crf4-1 NCU04058 NCU04058 mus-21 mus-21 NCU06049 NCU06049 esa-1 esa-1 NCU06269 NCU06269 mus-59 mus-59 ham-4 ham-4 prd-4 prd-4 NCU00800 NCU00800 mus-23 mus-23 NCU08955 NCU08955
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ubiPolyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys [...] (305 aa)
ubi::crp-6Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (154 aa)
hh2bHistone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (137 aa)
uvs-6UVS6. (1314 aa)
crf4-1Chromatin remodelling complex ATPase chain ISW1. (1126 aa)
NCU04058BZIP domain-containing protein. (306 aa)
mus-21Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2939 aa)
NCU06049DNA damage response protein RcaA. (912 aa)
esa-1Histone acetyltransferase esa-1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recr [...] (506 aa)
NCU06269FHA domain-containing protein. (790 aa)
mus-59Serine/threonine-protein kinase. (1233 aa)
ham-4FHA domain-containing protein. (797 aa)
prd-4Serine/threonine-protein kinase chk2. (702 aa)
NCU00800Protein kinase domain-containing protein. (756 aa)
mus-23Double-strand break repair protein mus-23; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity); Belongs to the MRE11/RAD32 family. (739 aa)
NCU08955UBX domain-containing protein, variant. (317 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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