41 items (Neurospora crassa) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	prk-3	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (407 aa)
	NCU01515	DNA-directed RNA polymerase II polypeptide. (337 aa)
	NCU01831	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (469 aa)
	NCU01067	CYCLIN domain-containing protein. (427 aa)
	NCU04363	Uncharacterized protein. (690 aa)
	ctc-1	FACT complex subunit ctc-1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (565 aa)
	NCU01625	DNA repair helicase RAD3. (806 aa)
	NCU04508	Uncharacterized protein. (75 aa)
	NCU04495	C-type cyclin. (442 aa)
	NCU05120	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1287 aa)
	NCU06438	DNA repair helicase RAD25. (862 aa)
	NCU05943	TFIIS central domain-containing protein. (1050 aa)
	trf-3	Transcription elongation factor spt5; The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (1054 aa)
	NCU06889	Uncharacterized protein. (532 aa)
	NCU05523	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (501 aa)
	trf-2	Transcription elongation factor spt4; The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (120 aa)
	NCU05305	DNA-directed RNA polymerase II polypeptide. (234 aa)
	NCU08030	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (152 aa)
	NCU08006	Uncharacterized protein. (727 aa)
	NCU08553	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (130 aa)
	NCU00806	Uncharacterized protein. (238 aa)
	NCU09382	TPR domain-containing protein. (386 aa)
	NCU09378	DNA-directed RNA polymerase II polypeptide. (146 aa)
	NCU03047	Uncharacterized protein. (345 aa)
	NCU03406	Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (109 aa)
	stk-47	Protein kinase. (1250 aa)
	NCU09300	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (868 aa)
	NCU03782	DNA-directed RNA polymerase II subunit RPB11. (133 aa)
	tcf-29	General transcription and DNA repair factor IIH subunit tcf-29; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has [...] (663 aa)
	ctc-2	FACT complex subunit ctc-2; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1032 aa)
	rtf-1	General transcription and DNA repair factor IIH subunit rtf-1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has b [...] (72 aa)
	stk-1	Serine/threonine-protein kinase bur1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the mus-8/ubc2 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). (559 aa)
	NCU01580	Transcription factor TFIIH subunit Tfb4. (439 aa)
	NCU11252	Cyclin Pch1; Belongs to the cyclin family. (547 aa)
	NCU11012	DNA-directed RNA polymerase I. (160 aa)
	NCU02563	Transcription elongation factor S-II. (298 aa)
	NCU02587	RNA polymerase II transcription factor B subunit 3. (362 aa)
	NCU02661	DNA-directed RNA polymerase II polypeptide. (171 aa)
	NCU02605	DNA-directed RNA polymerase I/II/III subunit 10. (84 aa)
	NCU09259	Uncharacterized protein. (625 aa)
	NCU02103	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1761 aa)

Your Current Organism:

Neurospora crassa

NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NCU00806	NCU01067	Q7SCT6	Q1K8A2	Uncharacterized protein.	CYCLIN domain-containing protein.	0.635
NCU00806	NCU01515	Q7SCT6	Q1K5K1	Uncharacterized protein.	DNA-directed RNA polymerase II polypeptide.	0.906
NCU00806	NCU01580	Q7SCT6	Q1K4W6	Uncharacterized protein.	Transcription factor TFIIH subunit Tfb4.	0.614
NCU00806	NCU02103	Q7SCT6	Q7SDN0	Uncharacterized protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.867
NCU00806	NCU02563	Q7SCT6	Q7SHQ2	Uncharacterized protein.	Transcription elongation factor S-II.	0.722
NCU00806	NCU02587	Q7SCT6	Q7SHN1	Uncharacterized protein.	RNA polymerase II transcription factor B subunit 3.	0.620
NCU00806	NCU02605	Q7SCT6	Q7SG15	Uncharacterized protein.	DNA-directed RNA polymerase I/II/III subunit 10.	0.664
NCU00806	NCU02661	Q7SCT6	Q7SH68	Uncharacterized protein.	DNA-directed RNA polymerase II polypeptide.	0.903
NCU00806	NCU03047	Q7SCT6	Q7SD24	Uncharacterized protein.	Uncharacterized protein.	0.856
NCU00806	NCU03782	Q7SCT6	V5IL63	Uncharacterized protein.	DNA-directed RNA polymerase II subunit RPB11.	0.807
NCU00806	NCU04363	Q7SCT6	Q7RWR7	Uncharacterized protein.	Uncharacterized protein.	0.946
NCU00806	NCU04495	Q7SCT6	Q7RYB2	Uncharacterized protein.	C-type cyclin.	0.469
NCU00806	NCU04508	Q7SCT6	Q7RY55	Uncharacterized protein.	Uncharacterized protein.	0.668
NCU00806	NCU05120	Q7SCT6	Q7RYF4	Uncharacterized protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.865
NCU00806	NCU05305	Q7SCT6	Q7S8Z5	Uncharacterized protein.	DNA-directed RNA polymerase II polypeptide.	0.735
NCU00806	NCU06889	Q7SCT6	Q7S3G4	Uncharacterized protein.	Uncharacterized protein.	0.867
NCU00806	NCU08006	Q7SCT6	Q7SAN5	Uncharacterized protein.	Uncharacterized protein.	0.469
NCU00806	NCU08030	Q7SCT6	Q7SAL1	Uncharacterized protein.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.662
NCU00806	NCU08553	Q7SCT6	Q7SBJ7	Uncharacterized protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.711
NCU00806	NCU09259	Q7SCT6	Q7SF51	Uncharacterized protein.	Uncharacterized protein.	0.810

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