STRINGSTRING
stk-20 stk-20 ckb-2 ckb-2 ckb-1 ckb-1 cka cka ctc-2 ctc-2 NCU17268 NCU17268 stk-46 stk-46 un-1 un-1 NCU03337 NCU03337 prk-11 prk-11 mus-9 mus-9 ubi ubi ubi::crp-6 ubi::crp-6 rpa-1 rpa-1 NCU03765 NCU03765 ctc-1 ctc-1 stk-30 stk-30 NCU00081 NCU00081 NCU04058 NCU04058 mdm34 mdm34 NCU09503 NCU09503 NCU09439 NCU09439 NCU05536 NCU05536 stk-5 stk-5 qde-3 qde-3 ptk-2 ptk-2 prd-4 prd-4 NCU02066 NCU02066
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
stk-20Serine/threonine protein kinase-20. (602 aa)
ckb-2Casein kinase II subunit beta-2; Plays a complex role in regulating the basal catalytic activity of the alpha subunit. (285 aa)
ckb-1Casein kinase II subunit beta-1; Plays a complex role in regulating the basal catalytic activity of the alpha subunit. (333 aa)
ckaCasein kinase II subunit alpha; Phosphorylates the frq clock protein thus regulating the circadian clock; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily. (336 aa)
ctc-2FACT complex subunit ctc-2; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1032 aa)
NCU17268Uncharacterized protein. (286 aa)
stk-46Serine/threonine protein kinase. (1405 aa)
un-1Serine/threonine protein kinase. (620 aa)
NCU03337ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (483 aa)
prk-11Serine/threonine-protein kinase BUD32. (299 aa)
mus-9Phosphatidyl inositol 3-kinase; Belongs to the PI3/PI4-kinase family. (2492 aa)
ubiPolyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys [...] (305 aa)
ubi::crp-6Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (154 aa)
rpa-1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
NCU037653'-5' exonuclease/helicase. (753 aa)
ctc-1FACT complex subunit ctc-1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (565 aa)
stk-30Protein kinase. (757 aa)
NCU00081DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (695 aa)
NCU04058BZIP domain-containing protein. (306 aa)
mdm34Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm-1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. (615 aa)
NCU09503Uncharacterized protein. (1048 aa)
NCU09439RecQ mediated genome instability protein Rmi1. (284 aa)
NCU05536Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit. (1010 aa)
stk-5Serine/threonine-protein kinase hal4; Belongs to the protein kinase superfamily. (497 aa)
qde-3RecQ family helicase. (2330 aa)
ptk-2Serine/threonine protein kinase. (713 aa)
prd-4Serine/threonine-protein kinase chk2. (702 aa)
NCU02066Ribosome assembly protein Noc2. (790 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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