STRINGSTRING
NCU16705 NCU16705 rpa-3 rpa-3 mus-9 mus-9 NCU10467 NCU10467 cdc7 cdc7 NCU01090 NCU01090 ubi ubi hh2b hh2b NCU01824 NCU01824 NCU01370 NCU01370 NCU04327 NCU04327 mrc1 mrc1 rpa-1 rpa-1 NCU01171 NCU01171 NCU05433 NCU05433 NCU08427 NCU08427 NCU03765 NCU03765 cdc28 cdc28 nfh-2 nfh-2 mdk-1 mdk-1 stk-30 stk-30 NCU00081 NCU00081 NCU04378 NCU04378 fi fi NCU05972 NCU05972 NCU05907 NCU05907 NCU09855 NCU09855 NCU09503 NCU09503 NCU09439 NCU09439 NCU05820 NCU05820 NCU04738 NCU04738 NCU03840 NCU03840 rpa-2 rpa-2 NCU05194 NCU05194 NCU08317 NCU08317 NCU08009 NCU08009 NCU06269 NCU06269 stk-5 stk-5 mus-59 mus-59 MCM7 MCM7 qde-3 qde-3 ham-4 ham-4 ptk-2 ptk-2 NCU02776 NCU02776 NCU00517 NCU00517 prd-4 prd-4 NCU00800 NCU00800 NCU02496 NCU02496 NCU02965 NCU02965 NCU02687 NCU02687 NCU02683 NCU02683 stk-20 stk-20 NCU02539 NCU02539 B14D6.460 B14D6.460 NCU16653 NCU16653 NCU00470 NCU00470 NCU17268 NCU17268 NCU03820 NCU03820 NCU09860 NCU09860 NCU04212 NCU04212 un-1 un-1 NCU03337 NCU03337 NCU10376 NCU10376 NCU16423 NCU16423 NCU16422 NCU16422 nfh-1 nfh-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU16705Chromo domain-containing protein. (145 aa)
rpa-3Replication protein A-3. (108 aa)
mus-9Phosphatidyl inositol 3-kinase; Belongs to the PI3/PI4-kinase family. (2492 aa)
NCU10467Replication factor C subunit 4. (357 aa)
cdc7Cell cycle protein kinase. (526 aa)
NCU01090Uncharacterized protein. (656 aa)
ubiPolyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys [...] (305 aa)
hh2bHistone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (137 aa)
NCU01824UDP-galactopyranose mutase. (517 aa)
NCU01370Uncharacterized protein. (603 aa)
NCU04327DNA helicase; Belongs to the MCM family. (882 aa)
mrc1MRC1. (1464 aa)
rpa-1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
NCU01171DNA helicase; Belongs to the MCM family. (724 aa)
NCU05433Uncharacterized protein. (412 aa)
NCU08427Activator 1 subunit 3. (389 aa)
NCU037653'-5' exonuclease/helicase. (753 aa)
cdc28Cell division control protein 2; Belongs to the protein kinase superfamily. (328 aa)
nfh-214-3-3 family protein 7; Belongs to the 14-3-3 family. (262 aa)
mdk-1Cyclin-dependent protein kinase; Belongs to the protein kinase superfamily. (337 aa)
stk-30Protein kinase. (757 aa)
NCU00081DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (695 aa)
NCU04378DNA replication initiation factor Cdc45. (874 aa)
fiProtein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
NCU05972Sporulation-specific protein 6. (706 aa)
NCU05907Uncharacterized protein. (129 aa)
NCU09855Nicotianamine synthase. (339 aa)
NCU09503Uncharacterized protein. (1048 aa)
NCU09439RecQ mediated genome instability protein Rmi1. (284 aa)
NCU05820Uncharacterized protein. (477 aa)
NCU04738Zf-primase domain-containing protein. (977 aa)
NCU0384014_3_3 domain-containing protein. (314 aa)
rpa-2Replication protein A-2. (284 aa)
NCU05194DNA helicase; Belongs to the MCM family. (972 aa)
NCU08317PHD-type domain-containing protein. (1021 aa)
NCU08009DNA helicase; Belongs to the MCM family. (944 aa)
NCU06269FHA domain-containing protein. (790 aa)
stk-5Serine/threonine-protein kinase hal4; Belongs to the protein kinase superfamily. (497 aa)
mus-59Serine/threonine-protein kinase. (1233 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (824 aa)
qde-3RecQ family helicase. (2330 aa)
ham-4FHA domain-containing protein. (797 aa)
ptk-2Serine/threonine protein kinase. (713 aa)
NCU02776Cell division control protein; Belongs to the CDC6/cdc18 family. (691 aa)
NCU00517Cell cycle checkpoint protein RAD17. (944 aa)
prd-4Serine/threonine-protein kinase chk2. (702 aa)
NCU00800Protein kinase domain-containing protein. (756 aa)
NCU02496M-phase inducer phosphatase 3. (554 aa)
NCU02965Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (766 aa)
NCU02687Activator 1 41 kDa subunit. (387 aa)
NCU02683Uncharacterized protein. (738 aa)
stk-20Serine/threonine protein kinase-20. (602 aa)
NCU02539DNA helicase; Belongs to the MCM family. (1013 aa)
B14D6.460Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. (352 aa)
NCU16653Uncharacterized protein. (210 aa)
NCU00470DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (484 aa)
NCU17268Uncharacterized protein. (286 aa)
NCU03820Checkpoint protein; Belongs to the HUS1 family. (371 aa)
NCU09860Telomere silencing protein Zds1, variant. (870 aa)
NCU04212Uncharacterized protein. (511 aa)
un-1Serine/threonine protein kinase. (620 aa)
NCU03337ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (483 aa)
NCU10376Uncharacterized protein. (441 aa)
NCU16423Uncharacterized protein. (378 aa)
NCU16422Uncharacterized protein. (79 aa)
nfh-1DNA damage checkpoint protein rad24, variant; Belongs to the 14-3-3 family. (224 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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