STRINGSTRING
acr-2 acr-2 crp-79 crp-79 hh2b hh2b NCU01580 NCU01580 NCU01831 NCU01831 NCU07166 NCU07166 prk-3 prk-3 NCU01067 NCU01067 NCU04770 NCU04770 NCU01625 NCU01625 NCU04508 NCU04508 NCU06485 NCU06485 NCU06438 NCU06438 NCU06874 NCU06874 NCU05523 NCU05523 NCU05251 NCU05251 NCU05240 NCU05240 NCU05305 NCU05305 NCU08030 NCU08030 tcf-29 tcf-29 NCU16890 NCU16890 NCU09247 NCU09247 NCU02605 NCU02605 NCU02587 NCU02587 NCU02533 NCU02533 rtf-1 rtf-1 NCU11012 NCU11012 NCU01638 NCU01638
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acr-2DNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). (1234 aa)
crp-79Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
hh2bHistone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (137 aa)
NCU01580Transcription factor TFIIH subunit Tfb4. (439 aa)
NCU01831General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (469 aa)
NCU07166Uncharacterized protein. (448 aa)
prk-3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (407 aa)
NCU01067CYCLIN domain-containing protein. (427 aa)
NCU04770TATA-binding protein. (257 aa)
NCU01625DNA repair helicase RAD3. (806 aa)
NCU04508Uncharacterized protein. (75 aa)
NCU06485Uncharacterized protein. (436 aa)
NCU06438DNA repair helicase RAD25. (862 aa)
NCU06874HMG box-containing protein. (892 aa)
NCU05523RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (501 aa)
NCU05251DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (122 aa)
NCU05240SAP30_Sin3_bdg domain-containing protein. (219 aa)
NCU05305DNA-directed RNA polymerase II polypeptide. (234 aa)
NCU08030DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (152 aa)
tcf-29General transcription and DNA repair factor IIH subunit tcf-29; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has [...] (663 aa)
NCU16890RRN7-type domain-containing protein. (576 aa)
NCU09247Uncharacterized protein. (716 aa)
NCU02605DNA-directed RNA polymerase I/II/III subunit 10. (84 aa)
NCU02587RNA polymerase II transcription factor B subunit 3. (362 aa)
NCU02533DNA-directed RNA polymerase I and III polypeptide. (378 aa)
rtf-1General transcription and DNA repair factor IIH subunit rtf-1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has b [...] (72 aa)
NCU11012DNA-directed RNA polymerase I. (160 aa)
NCU01638DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1701 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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