STRINGSTRING
NCU04786 NCU04786 NCU09793 NCU09793 dbp-3 dbp-3 NCU05802 NCU05802 drh-10 drh-10 has-1 has-1 mus-41 mus-41 crf10-1 crf10-1 crf1-1 crf1-1 NCU09756 NCU09756 NCU07411 NCU07411 mak-5 mak-5 NCU04424 NCU04424 dbp-4 dbp-4 NCU04445 NCU04445 dbp-8 dbp-8 NCU06438 NCU06438 crf3-1 crf3-1 rrp-3 rrp-3 crf4-1 crf4-1 NCU01625 NCU01625 NCU04354 NCU04354 NCU09076 NCU09076 mus-25 mus-25 tif-1 tif-1 NCU06735 NCU06735 cyt-19 cyt-19 rad16 rad16 NCU03808 NCU03808 NCU08928 NCU08928 NCU01612 NCU01612 frh frh drh-11 drh-11 NCU01143 NCU01143 NCU10809 NCU10809 chl1 chl1 crf5-1 crf5-1 NCU07975 NCU07975 drh-1 drh-1 csb csb atrx atrx drh-15 drh-15 dcl-2 dcl-2 mph1 mph1 qde-3 qde-3 prp-28 prp-28 NCU09254 NCU09254 drh-16 drh-16 NCU09093 NCU09093 NCU02728 NCU02728 prp-5 prp-5 NCU02685 NCU02685 NCU01857 NCU01857 NCU02913 NCU02913 crf9-1 crf9-1 crf2-1 crf2-1 spb-4 spb-4 dbp-5 dbp-5 drh-9 drh-9 fal-1 fal-1 crf8-1 crf8-1 NCU04472 NCU04472 NCU03337 NCU03337 crf6-1 crf6-1 NCU06318 NCU06318 NCU06365 NCU06365 NCU06371 NCU06371 dbp-10 dbp-10 NCU05246 NCU05246 NCU08267 NCU08267 dcl-1 dcl-1 dbp-7 dbp-7 NCU01104 NCU01104 csa csa crf7-1 crf7-1 dbp-9 dbp-9
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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NCU04786SNF2 family helicase/ATPase. (1197 aa)
NCU09793DEAD/DEAH box DNA helicase. (1563 aa)
dbp-3ATP-dependent RNA helicase dbp-3; ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity); Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. (614 aa)
NCU05802ATP-dependent RNA helicase A. (1491 aa)
drh-10ATP-dependent RNA helicase dhh1; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (569 aa)
has-1ATP-dependent RNA helicase has-1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (578 aa)
mus-41DNA repair protein rad5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein uvs-2/rad18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1228 aa)
crf10-1Clockswitch protein CSW-1. (1011 aa)
crf1-1Helicase swr-1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1845 aa)
NCU09756Uncharacterized protein; Belongs to the DEAD box helicase family. (784 aa)
NCU07411DNA-directed DNA polymerase theta. (999 aa)
mak-5ATP-dependent RNA helicase mak-5; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily. (805 aa)
NCU04424Uncharacterized protein. (478 aa)
dbp-4ATP-dependent RNA helicase dbp-4; ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity). (823 aa)
NCU04445Uncharacterized protein. (1217 aa)
dbp-8ATP-dependent RNA helicase dbp-8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. (626 aa)
NCU06438DNA repair helicase RAD25. (862 aa)
crf3-1SNF2-family ATP dependent chromatin remodeling factor snf21. (1482 aa)
rrp-3ATP-dependent rRNA helicase rrp-3; Required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA (By similarity). (515 aa)
crf4-1Chromatin remodelling complex ATPase chain ISW1. (1126 aa)
NCU01625DNA repair helicase RAD3. (806 aa)
NCU04354DEAD box family helicase. (684 aa)
NCU09076ATP-dependent RNA helicase. (434 aa)
mus-25DNA repair and recombination protein RAD54. (835 aa)
tif-1ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). (397 aa)
NCU06735ATP dependent RNA helicase. (682 aa)
cyt-19ATP-dependent RNA helicase cyt-19, mitochondrial; Acts as an RNA chaperone to resolve non-native structures formed during RNA folding to promote mitochondrial group I, but also group II, intron splicing. Functions predominantly by disrupting accessible RNA secondary structure and depends on spontaneous openings in tightly packed RNAs to gain access to RNA helices. Belongs to the DEAD box helicase family. (626 aa)
rad16DNA repair protein RAD16. (1079 aa)
NCU03808Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16. (1258 aa)
NCU08928ATP-dependent RNA helicase DHX8. (917 aa)
NCU01612Pre-mRNA splicing factor ATP-dependent RNA helicase PRP43. (774 aa)
frhFRQ-interacting RNA helicase. (1106 aa)
drh-11ATP-dependent RNA helicase drs1; ATP-binding RNA helicase involved in ribosome assembly. (829 aa)
NCU01143DEAD/DEAH box helicase. (1391 aa)
NCU10809Uncharacterized protein. (830 aa)
chl1ATP-dependent DNA helicase chl1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (1068 aa)
crf5-1Chromatin remodeling factor 5-1. (907 aa)
NCU07975DNA repair and recombination protein RAD5B. (950 aa)
drh-1ATP-dependent RNA helicase dbp2; ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing. (562 aa)
csbDNA repair protein Rhp26/Rad26. (1173 aa)
atrxATRX. (1869 aa)
drh-15ATP-dependent RNA helicase mrh4, mitochondrial; ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity); Belongs to the DEAD box helicase family. MRH4 subfamily. (625 aa)
dcl-2ATP-dependent helicase dcl-2; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume. (1534 aa)
mph1ATP-dependent DNA helicase mph1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1168 aa)
qde-3RecQ family helicase. (2330 aa)
prp-28Pre-mRNA-splicing ATP-dependent RNA helicase prp-28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). (728 aa)
NCU09254Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16. (840 aa)
drh-16ATP-dependent RNA helicase rok1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (781 aa)
NCU09093DEAD box RNA helicase-PL10B; Belongs to the DEAD box helicase family. (593 aa)
NCU02728Pre-mRNA splicing factor ATP-dependent RNA helicase prp16. (1005 aa)
prp-5Pre-mRNA-processing ATP-dependent RNA helicase prp-5; ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity); Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (1194 aa)
NCU02685Pre-mRNA splicing helicase. (2209 aa)
NCU01857DEAD/DEAH box RNA helicase. (1294 aa)
NCU02913DNA repair protein rad5. (679 aa)
crf9-1RING-13 protein. (1214 aa)
crf2-1Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1997 aa)
spb-4ATP-dependent rRNA helicase spb-4; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. (654 aa)
dbp-5ATP-dependent RNA helicase dbp-5; ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity). (483 aa)
drh-9ATP-dependent RNA helicase ded1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (688 aa)
fal-1ATP-dependent RNA helicase fal-1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity). Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily. (400 aa)
crf8-1TBP associated factor, variant. (1893 aa)
NCU04472DEAD/DEAH box helicase. (1847 aa)
NCU03337ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (483 aa)
crf6-1Chromodomain helicase, variant. (1664 aa)
NCU06318ATP-dependent RNA helicase DHX8. (1179 aa)
NCU06365DEAD/DEAH box helicase. (1175 aa)
NCU06371Mitochondrial ATP-dependent RNA helicase Suv3. (796 aa)
dbp-10ATP-dependent RNA helicase dbp-10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (934 aa)
NCU05246DNA repair and recombination protein RAD5C. (1111 aa)
NCU08267Activating signal cointegrator 1 complex subunit 3. (2066 aa)
dcl-1ATP-dependent helicase dcl-1; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume. (1584 aa)
dbp-7ATP-dependent RNA helicase dbp-7; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. (814 aa)
NCU01104ATP-dependent RNA helicase MSS116. (696 aa)
csaDNA excision repair protein. (1269 aa)
crf7-1Chromodomain-helicase-DNA-binding protein 4. (1726 aa)
dbp-9ATP-dependent RNA helicase dbp-9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (676 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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