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NCU04596 NCU04596 met-7 met-7 eth-1 eth-1 NCU01652 NCU01652 NCU05093 NCU05093 met-8 met-8 NCU04292 NCU04292 NCU03761 NCU03761 NCU04118 NCU04118 NCU01163 NCU01163 spe-2 spe-2 met-5 met-5 met-2 met-2 cys-16 cys-16 dim-2 dim-2 NCU01439 NCU01439 ser-7 ser-7 adi1 adi1 cys-17 cys-17 Nic-7 Nic-7 NCU03935 NCU03935 NCU10020 NCU10020 tca-15 tca-15 NCU04657 NCU04657 NCU08216 NCU08216 NCU06017 NCU06017 mri-1 mri-1 ilv-6 ilv-6 NCU06625 NCU06625 NCU07941 NCU07941 utr4 utr4 NCU08117 NCU08117 tca-17 tca-17 mde-1 mde-1 hom-1 hom-1 NCU00799 NCU00799 NCU00792 NCU00792 cys-12 cys-12 gcs-1 gcs-1 spe-3 spe-3 NCU06191 NCU06191 tca-16 tca-16 cys-18 cys-18 rid-1 rid-1 NCU08411 NCU08411 NCU09116 NCU09116
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU04596Gamma-cysteine synthetase regulatory subunit. (333 aa)
met-7Cystathionine gamma-synthase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity). (621 aa)
eth-1S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. (395 aa)
NCU01652O-acetylhomoserine. (454 aa)
NCU05093Cystathionine gamma-synthase. (657 aa)
met-8Methionine synthase. (769 aa)
NCU04292Branched-chain-amino-acid aminotransferase. (414 aa)
NCU03761PALP domain-containing protein. (404 aa)
NCU04118Aspartokinase. (522 aa)
NCU01163GAF domain nucleotide-binding protein. (176 aa)
spe-2S-adenosylmethionine decarboxylase. (503 aa)
met-5Homoserine O-acetyltransferase. (437 aa)
met-2Cystathionine beta-lyase; Involved in de novo synthesis of methionine. Belongs to the trans-sulfuration enzymes family. (457 aa)
cys-16Cystathionine gamma-lyase. (417 aa)
dim-2DNA methyltransferase Dim-2. (1454 aa)
NCU01439D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (466 aa)
ser-7Phosphoserine aminotransferase. (429 aa)
adi11,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (178 aa)
cys-17Cysteine synthase 1; Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine; Belongs to the cysteine synthase/cystathionine beta- synthase family. (376 aa)
Nic-7S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (310 aa)
NCU03935Homoserine dehydrogenase. (365 aa)
NCU10020Methionine synthase. (385 aa)
tca-15Malate dehydrogenase. (336 aa)
NCU046571-aminocyclopropane-1-carboxylate deaminase. (359 aa)
NCU08216Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (528 aa)
NCU06017Thiosulfate sulfurtransferase. (333 aa)
mri-1Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (388 aa)
ilv-6Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (405 aa)
NCU06625Cysteine dioxygenase. (235 aa)
NCU07941Aspartate aminotransferase. (482 aa)
utr4Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (234 aa)
NCU08117Uncharacterized protein. (675 aa)
tca-17L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (324 aa)
mde-1Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). (258 aa)
hom-1Aspartate-semialdehyde dehydrogenase. (362 aa)
NCU00799Homocysteine S-methyltransferase. (361 aa)
NCU00792Branched-chain-amino-acid aminotransferase. (413 aa)
cys-12Cysteine synthase 2; Putative cysteine synthase that catalyzes the conversion of O-acetyl-L-serine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway. However, in contrast to cysteine synthase cys-17, this CS-like protein may not function in cysteine biosynthesis. (456 aa)
gcs-1Glutamate--cysteine ligase; Belongs to the glutamate--cysteine ligase type 3 family. (728 aa)
spe-3Spermidine synthase; Belongs to the spermidine/spermine synthase family. (291 aa)
NCU06191Glutathione synthetase. (554 aa)
tca-16Malate dehydrogenase. (331 aa)
cys-18Adenosylhomocysteinase. (449 aa)
rid-1RIP defective; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (837 aa)
NCU08411Aspartate aminotransferase. (428 aa)
NCU09116Aromatic aminotransferase Aro8, variant. (560 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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