STRINGSTRING
Arg-4 Arg-4 NCU10107 NCU10107 NCU10106 NCU10106 trp-2 trp-2 NCU01328 NCU01328 NCU03748 NCU03748 trp-1 trp-1 qa-2 qa-2 his-3 his-3 trp-3 trp-3 aga-1 aga-1 cit-1 cit-1 leu-1 leu-1 for for pgk-1 pgk-1 ilv-2 ilv-2 met-7 met-7 eth-1 eth-1 fba fba gpd-1 gpd-1 arg-6 arg-6 aro-8 aro-8 aro-2 aro-2 pro-1 pro-1 NCU01786 NCU01786 NCU01652 NCU01652 NCU03425 NCU03425 arg-12 arg-12 ilv-4 ilv-4 NCU05093 NCU05093 met-8 met-8 his-6 his-6 NCU04579 NCU04579 pro-3 pro-3 NCU04303 NCU04303 NCU04298 NCU04298 NCU04292 NCU04292 NCU04280 NCU04280 thr-4 thr-4 NCU03761 NCU03761 NCU04118 NCU04118 NCU03607 NCU03607 arg-14 arg-14 met-5 met-5 met-2 met-2 cys-16 cys-16 lys-3 lys-3 emp-7 emp-7 ace-8 ace-8 NCU01439 NCU01439 ser-7 ser-7 his-7 his-7 pro-4 pro-4 cys-17 cys-17 trp-4 trp-4 NCU04401 NCU04401 leu-2 leu-2 ala ala NCU03935 NCU03935 NCU10020 NCU10020 tpi-1 tpi-1 NCU08216 NCU08216 NCU02227 NCU02227 arg-10 arg-10 tca-3 tca-3 emp-6 emp-6 cbs-2 cbs-2 ilv-6 ilv-6 aro-6 aro-6 NCU05254 NCU05254 NCU07725 NCU07725 tca-4 tca-4 NCU06360 NCU06360 NCU07941 NCU07941 NCU06974 NCU06974 NCU05683 NCU05683 NCU00519 NCU00519 aro-7 aro-7 NCU08117 NCU08117 his-2 his-2 NCU02136 NCU02136 hom-1 hom-1 leu-4 leu-4 NCU02004 NCU02004 NCU00792 NCU00792 tca-6 tca-6 lys-4 lys-4 NCU02479 NCU02479 thr-5 thr-5 lys-7 lys-7 NCU01870 NCU01870 cys-12 cys-12 suc suc emp-3 emp-3 gln-1 gln-1 lys-4-2 lys-4-2 aro-1 aro-1 65E11.030 65E11.030 arg-8 arg-8 NCU00468 NCU00468 NCU00409 NCU00409 NCU02450 NCU02450 lys-5 lys-5 tca-5 tca-5 gln-2 gln-2 ppm-3 ppm-3 NCU06970 NCU06970 en(am)-2 en(am)-2 NCU07982 NCU07982 rpd rpd arg-1 arg-1 NCU08411 NCU08411 tca-2 tca-2 NCU09116 NCU09116
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Arg-4Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate. (469 aa)
NCU10107Ribose 5-phosphate isomerase. (173 aa)
NCU10106Triosephosphate isomerase. (300 aa)
trp-2Anthranilate synthase component I. (582 aa)
NCU01328Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (686 aa)
NCU03748Saccharopine dehydrogenase. (448 aa)
trp-1Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities. (762 aa)
qa-2Catabolic 3-dehydroquinase; Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway; Belongs to the type-II 3-dehydroquinase family. (173 aa)
his-3Histidine biosynthesis trifunctional protein. (870 aa)
trp-3Tryptophan synthase; In the C-terminal section; belongs to the TrpB family. (708 aa)
aga-1Arginase; Belongs to the arginase family. (358 aa)
cit-1Citrate synthase, mitochondrial. (469 aa)
leu-13-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (368 aa)
forSerine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. (480 aa)
pgk-1Phosphoglycerate kinase. (418 aa)
ilv-2Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family. (402 aa)
met-7Cystathionine gamma-synthase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity). (621 aa)
eth-1S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. (395 aa)
fbaFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (362 aa)
gpd-1Glyceraldehyde-3-phosphate dehydrogenase. (338 aa)
arg-6N-acetyl-gamma-glutamyl-phosphate reductase; In the N-terminal section; belongs to the acetylglutamate kinase family. (871 aa)
aro-8Phospho-2-dehydro-3-deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (481 aa)
aro-2Chorismate synthase; Bifunctional enzyme that possesses chorismate synthase and intrinsic flavin reductase activity, it uses NADPH to reduce FMN. (432 aa)
pro-1Pyrroline-5-carboxylate reductase. (332 aa)
NCU01786Ribose-phosphate pyrophosphokinase II. (412 aa)
NCU01652O-acetylhomoserine. (454 aa)
NCU03425Threonine synthase. (553 aa)
arg-12Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (385 aa)
ilv-4Acetolactate synthase small subunit. (330 aa)
NCU05093Cystathionine gamma-synthase. (657 aa)
met-8Methionine synthase. (769 aa)
his-6Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family. (553 aa)
NCU04579Dihydroxy-acid dehydratase. (596 aa)
pro-3Gamma-glutamyl phosphate reductase. (445 aa)
NCU04303Asparagine synthetase 2. (581 aa)
NCU04298Pentafunctional AROM polypeptide. (760 aa)
NCU04292Branched-chain-amino-acid aminotransferase. (414 aa)
NCU04280Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (809 aa)
thr-4Homoserine kinase. (358 aa)
NCU03761PALP domain-containing protein. (404 aa)
NCU04118Aspartokinase. (522 aa)
NCU03607Threonine dehydratase catabolic. (388 aa)
arg-14Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. (712 aa)
met-5Homoserine O-acetyltransferase. (437 aa)
met-2Cystathionine beta-lyase; Involved in de novo synthesis of methionine. Belongs to the trans-sulfuration enzymes family. (457 aa)
cys-16Cystathionine gamma-lyase. (417 aa)
lys-3L-aminoadipate-semialdehyde dehydrogenase large subunit. (1174 aa)
emp-7Enolase. (438 aa)
ace-8Pyruvate kinase. (527 aa)
NCU01439D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (466 aa)
ser-7Phosphoserine aminotransferase. (429 aa)
his-71-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (257 aa)
pro-4Glutamate 5-kinase. (468 aa)
cys-17Cysteine synthase 1; Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine; Belongs to the cysteine synthase/cystathionine beta- synthase family. (376 aa)
trp-4Anthranilate phosphoribosyltransferase. (436 aa)
NCU04401Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (288 aa)
leu-23-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (779 aa)
alaAlanine aminotransferase. (566 aa)
NCU03935Homoserine dehydrogenase. (365 aa)
NCU10020Methionine synthase. (385 aa)
tpi-1Triosephosphate isomerase; Belongs to the triosephosphate isomerase family. (248 aa)
NCU08216Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (528 aa)
NCU02227Acetylornithine deacetylase. (452 aa)
arg-10Argininosuccinate lyase. (466 aa)
tca-3Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (784 aa)
emp-6Phosphoglycerate mutase. (519 aa)
cbs-2Putative serine hydroxymethyltransferase, mitochondrial; Interconversion of serine and glycine. (546 aa)
ilv-6Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (405 aa)
aro-6Phospho-2-dehydro-3-deoxyheptonate aldolase. (379 aa)
NCU05254Ribose-phosphate pyrophosphokinase. (485 aa)
NCU07725Chorismate mutase. (269 aa)
tca-4Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (379 aa)
NCU06360Histidinol-phosphate aminotransferase. (401 aa)
NCU07941Aspartate aminotransferase. (482 aa)
NCU06974Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (316 aa)
NCU05683Dihydroxy-acid dehydratase. (640 aa)
NCU00519Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (251 aa)
aro-7Phospho-2-dehydro-3-deoxyheptonate aldolase. (376 aa)
NCU08117Uncharacterized protein. (675 aa)
his-2ATP phosphoribosyltransferase. (337 aa)
NCU02136Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (324 aa)
hom-1Aspartate-semialdehyde dehydrogenase. (362 aa)
leu-42-isopropylmalate synthase. (625 aa)
NCU02004Phosphoserine phosphatase. (496 aa)
NCU00792Branched-chain-amino-acid aminotransferase. (413 aa)
tca-6Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
lys-4Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Catalyzes the NAD(+)-dependent cleavage of saccharopine to L- lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis; Belongs to the AlaDH/PNT family. (372 aa)
NCU02479Glutamine synthetase; Belongs to the glutamine synthetase family. (484 aa)
thr-5L-allo-threonine aldolase. (470 aa)
lys-7Homoisocitrate dehydrogenase. (402 aa)
NCU01870Eno3 protein. (441 aa)
cys-12Cysteine synthase 2; Putative cysteine synthase that catalyzes the conversion of O-acetyl-L-serine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway. However, in contrast to cysteine synthase cys-17, this CS-like protein may not function in cysteine biosynthesis. (456 aa)
sucPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1192 aa)
emp-3ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (845 aa)
gln-1Glutamine synthetase. (362 aa)
lys-4-2Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. (784 aa)
aro-13-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. In the 3rd section; belongs to the shikimate kinase family. In the C-terminal section; belongs to the shikimate dehydrogenase family. (1563 aa)
65E11.030Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family. (229 aa)
arg-8Acetylornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa)
NCU00468Prephenate dehydrogenase [NADP(+)]; Belongs to the prephenate/arogenate dehydrogenase family. (445 aa)
NCU00409Chorismate mutase/prephenate dehydratase, variant. (388 aa)
NCU02450Threonine dehydratase. (584 aa)
lys-5Homocitrate synthase, variant 1; Belongs to the alpha-IPM synthase/homocitrate synthase family. (425 aa)
tca-5Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (462 aa)
gln-2Glutamine synthetase. (394 aa)
ppm-3Ribose 5-phosphate isomerase A. (366 aa)
NCU06970Ribose-phosphate pyrophosphokinase II, variant. (323 aa)
en(am)-2Glutamate synthase, variant. (2116 aa)
NCU07982Acetolactate synthase. (689 aa)
rpdRibose-phosphate pyrophosphokinase II. (501 aa)
arg-1Argininosuccinate synthase. (417 aa)
NCU08411Aspartate aminotransferase. (428 aa)
tca-2Citrate synthase; Belongs to the citrate synthase family. (470 aa)
NCU09116Aromatic aminotransferase Aro8, variant. (560 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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