39 items (Neurospora crassa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:
	rpa-3	Replication protein A-3. (108 aa)
	NCU10467	Replication factor C subunit 4. (357 aa)
	NCU01580	Transcription factor TFIIH subunit Tfb4. (439 aa)
	NCU01831	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (469 aa)
	NCU03528	DNA polymerase delta subunit 4. (241 aa)
	prk-3	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (407 aa)
	NCU03763	DNA polymerase delta subunit 2. (525 aa)
	rpa-1	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
	pold-1	DNA polymerase. (1104 aa)
	NCU01067	CYCLIN domain-containing protein. (427 aa)
	NCU08427	Activator 1 subunit 3. (389 aa)
	mus-38	MUS38. (960 aa)
	NCU04548	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2259 aa)
	NCU01625	DNA repair helicase RAD3. (806 aa)
	NCU06481	DNA ligase. (923 aa)
	NCU06438	DNA repair helicase RAD25. (862 aa)
	cul-4	Ubiquitin ligase subunit CulD; Belongs to the cullin family. (1039 aa)
	NCU10155	DNA polymerase epsilon subunit B. (851 aa)
	NCU09706	DNA ligase. (917 aa)
	rad23	Rad23-like protein. (383 aa)
	mus-44	Mating-type switching protein swi10. (405 aa)
	mus-50	UvrD/REP helicase. (1105 aa)
	NCU05523	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (501 aa)
	NCU06585	Rad4 family protein. (1040 aa)
	rpa-2	Replication protein A-2. (284 aa)
	dim-8	DNA damage-binding protein 1. (1158 aa)
	NCU07998	Uncharacterized protein. (441 aa)
	csb	DNA repair protein Rhp26/Rad26. (1173 aa)
	NCU06767	Replication factor C subunit 1. (1086 aa)
	mus-43	DNA repair protein rad14. (435 aa)
	pcn	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
	mus-40	DNA excision repair protein Rad2. (1269 aa)
	NCU02687	Activator 1 41 kDa subunit. (387 aa)
	NCU02587	RNA polymerase II transcription factor B subunit 3. (362 aa)
	B14D6.460	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. (352 aa)
	rtf-1	General transcription and DNA repair factor IIH subunit rtf-1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has b [...] (72 aa)
	tcf-29	General transcription and DNA repair factor IIH subunit tcf-29; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has [...] (663 aa)
	NCU04821	Uncharacterized protein. (160 aa)
	NCU12087	Nitrilase. (897 aa)

Your Current Organism:

Neurospora crassa

NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B14D6.460	NCU01625	Q8X082	Q7RXF5	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	DNA repair helicase RAD3.	0.416
B14D6.460	NCU01831	Q8X082	Q1K578	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family.	0.576
B14D6.460	NCU02687	Q8X082	Q7SH42	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	Activator 1 41 kDa subunit.	0.999
B14D6.460	NCU03763	Q8X082	Q1K7B3	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	DNA polymerase delta subunit 2.	0.842
B14D6.460	NCU04548	Q8X082	Q7RWE3	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.927
B14D6.460	NCU06438	Q8X082	Q7RYX9	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	DNA repair helicase RAD25.	0.596
B14D6.460	NCU06481	Q8X082	Q7RYJ3	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	DNA ligase.	0.796
B14D6.460	NCU06767	Q8X082	Q7SCC0	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	Replication factor C subunit 1.	0.999
B14D6.460	NCU08427	Q8X082	Q1K8P6	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	Activator 1 subunit 3.	0.999
B14D6.460	NCU09706	Q8X082	Q7S2S0	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	DNA ligase.	0.794
B14D6.460	NCU10155	Q8X082	Q7S126	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	DNA polymerase epsilon subunit B.	0.934
B14D6.460	NCU10467	Q8X082	A7UWD6	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	Replication factor C subunit 4.	0.999
B14D6.460	dim-8	Q8X082	Q7S9R0	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	DNA damage-binding protein 1.	0.751
B14D6.460	mus-38	Q8X082	Q7RW07	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	MUS38.	0.697
B14D6.460	mus-40	Q8X082	Q7SG44	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	DNA excision repair protein Rad2.	0.451
B14D6.460	mus-43	Q8X082	Q7SCF3	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	DNA repair protein rad14.	0.568
B14D6.460	mus-44	Q8X082	Q7S6F7	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	Mating-type switching protein swi10.	0.657
B14D6.460	pcn	Q8X082	Q7SF71	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.965
B14D6.460	pold-1	Q8X082	Q1K845	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	DNA polymerase.	0.858
B14D6.460	rpa-1	Q8X082	Q1K7R9	Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.790

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