STRINGSTRING
NCU11209 NCU11209 NCU10430 NCU10430 NCU10400 NCU10400 NCU01523 NCU01523 NCU04137 NCU04137 NCU03898 NCU03898 kin kin hsps-1 hsps-1 NCU01791 NCU01791 NCU03440 NCU03440 NCU03438 NCU03438 NCU07173 NCU07173 NCU04014 NCU04014 NCU09673 NCU09673 NCU03947 NCU03947 NCU06404 NCU06404 NCU08340 NCU08340 hsp70-2 hsp70-2 NCU01822 NCU01822 NCU06410 NCU06410 NCU04541 NCU04541 NCU00435 NCU00435 rho-1 rho-1 NCU03955 NCU03955 NCU03890 NCU03890 vps27 vps27 NCU06942 NCU06942 NCU06939 NCU06939 NCU04637 NCU04637 NCU09572 NCU09572 NCU05753 NCU05753 prr-1 prr-1 mss4 mss4 NCU04783 NCU04783 hse1 hse1 NCU05232 NCU05232 NCU07734 NCU07734 NCU08811 NCU08811 NCU06595 NCU06595 NCU06342 NCU06342 NCU06284 NCU06284 NCU06989 NCU06989 NCU08023 NCU08023 NCU07991 NCU07991 aps-2 aps-2 NCU07658 NCU07658 NCU07584 NCU07584 NCU06192 NCU06192 NCU07843 NCU07843 NCU09469 NCU09469 NCU02830 NCU02830 fac-2 fac-2 NCU02781 NCU02781 NCU00814 NCU00814 NCU00725 NCU00725 NCU07438 NCU07438 NCU00895 NCU00895 NCU02743 NCU02743 vsp-5 vsp-5 NCU01918 NCU01918 snx-3 snx-3 NCU02510 NCU02510 vsp-3 vsp-3 17E5.300 17E5.300 fac-1 fac-1 cdc42 cdc42 NCU05195 NCU05195 NCU01854 NCU01854 NCU03050 NCU03050
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU11209Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (237 aa)
NCU10430SNF7 family protein. (215 aa)
NCU10400Phospholipase. (912 aa)
NCU01523GTP-binding protein ypt3. (214 aa)
NCU04137Vacuolar protein sorting-associated protein Vps5. (580 aa)
NCU03898ESCRT-II complex component. (225 aa)
kinKinesin heavy chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end. (928 aa)
hsps-1Heat shock 70 kDa protein. (646 aa)
NCU01791SNF7 family protein. (235 aa)
NCU03440AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (988 aa)
NCU03438Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (205 aa)
NCU07173ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (184 aa)
NCU04014Uncharacterized protein. (1116 aa)
NCU09673AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (437 aa)
NCU03947E3 ubiquitin-protein ligase. (817 aa)
NCU06404GTP-binding protein. (205 aa)
NCU08340ADP-ribosylation factor; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family. (185 aa)
hsp70-2Heat shock protein 70; Belongs to the heat shock protein 70 family. (585 aa)
NCU01822Vacuolar protein sorting-associated protein 29; Belongs to the VPS29 family. (239 aa)
NCU06410GTP-binding protein YPT52. (236 aa)
NCU04541SNF7 family protein. (218 aa)
NCU00435SNF7 family protein. (227 aa)
rho-1Rho-type GTPase. (195 aa)
NCU03955Phospholipase. (1885 aa)
NCU03890Stromal membrane-associated protein. (581 aa)
vps27Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. (724 aa)
NCU06942Vacuolar protein sorting-associated protein VPS4; Belongs to the AAA ATPase family. (441 aa)
NCU06939Endosome-associated ubiquitin isopeptidase. (586 aa)
NCU04637BAR adaptor protein RVS167. (467 aa)
NCU09572Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (192 aa)
NCU05753ESCRT-I component. (580 aa)
prr-1pH-response regulator protein palA/prr-1; Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease palB/cpr-8 via snf7/vps-3 to its substrate pacc-1 (By similarity); Belongs to the palA/RIM20 family. (854 aa)
mss4Phosphatidylinositol-4-phosphate 5-kinase its3. (1012 aa)
NCU04783EH domain binding protein epsin 2. (597 aa)
hse1Class E vacuolar protein-sorting machinery protein hse1; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB). (745 aa)
NCU05232AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (748 aa)
NCU07734Zinc finger protein gcs1. (390 aa)
NCU08811Arf GTPase-activating protein. (496 aa)
NCU06595Vacuolar protein sorting protein. (637 aa)
NCU06342Phospholipase. (978 aa)
NCU06284Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (881 aa)
NCU06989Senescence domain-containing protein. (518 aa)
NCU08023Cytohesin-2. (1626 aa)
NCU07991DUF292 domain-containing protein. (299 aa)
aps-2AP-2 complex subunit sigma; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). (143 aa)
NCU07658Protein transporter sec72. (1940 aa)
NCU07584Vacuolar segregation protein pep7. (685 aa)
NCU06192Vacuolar protein sorting-associated protein 45; Belongs to the STXBP/unc-18/SEC1 family. (590 aa)
NCU07843Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (267 aa)
NCU09469EF hand domain-containing protein. (1286 aa)
NCU02830ARF GTPase activator. (1151 aa)
fac-2F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (289 aa)
NCU02781Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family. (368 aa)
NCU00814Uncharacterized protein. (430 aa)
NCU00725Epsin-3. (521 aa)
NCU07438WASP-like protein las17p. (636 aa)
NCU00895RAB GTPase Ypt5. (220 aa)
NCU02743Vacuolar protein sorting protein 26. (327 aa)
vsp-5Sorting nexin-4; Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans- Golgi network, for cytoplasm to vacuole transport (Cvt), mitophagy, and pexophagy (By similarity). (493 aa)
NCU01918Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (169 aa)
snx-3Sorting nexin-3; Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity). (142 aa)
NCU02510Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1678 aa)
vsp-3Vacuolar-sorting protein snf7; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH (By similarity). (228 aa)
17E5.300Probable Ras-related protein Rab7; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (205 aa)
fac-1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (273 aa)
cdc42Rho-type GTPase. (196 aa)
NCU05195Uncharacterized protein. (484 aa)
NCU01854Uncharacterized protein. (214 aa)
NCU03050Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (319 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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