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| | dnaN | DNA polymerase III, beta subunit; Pfam matches to PF00712 DNA_pol3_beta, score 79.7, E-value 8.1E-021, and to PF02767 DNA_pol3_beta_2, score 52.1, E-value 1.9E-015. (356 aa) |
| | queF | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (127 aa) |
| | purB | Pfam match to PF00206 Lyase_1, score 189.2, E-value 9.4E-054; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (442 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase, beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (339 aa) |
| | Abu_0026 | Conserved hypothetical protein. (157 aa) |
| | gatB | glutamyl-tRNA(Gln) amidotransferase, subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (477 aa) |
| | accC1 | Acetyl CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa) |
| | Abu_0048 | Conserved hypothetical integral membrane protein; Pfam match to PF03653 UPF0093, score 173.1, E-value 6.2E-049. (183 aa) |
| | gltX1 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (469 aa) |
| | Abu_0067 | Fibronectin/fibrinogen-binding protein, putative; Pfam match to PF05670 DUF814, score 73.9, E-value 4.8E-019. (442 aa) |
| | thrS | threonyl-tRNA synthetase; Pfam matches to PF00587 tRNA-synt_2b, score 193.2, E-value 1.1E-055, and to PF03129 HGTP_anticodon, score 109.1, E-value 1.2E-029, and to PF07973 tRNA_SAD, score 93.6, E-value 5.4E-025; Belongs to the class-II aminoacyl-tRNA synthetase family. (602 aa) |
| | infC | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (175 aa) |
| | rpmI | Pfam match to PF01632 Ribosomal_L35p, score 42.6, E-value 1E-005; Belongs to the bacterial ribosomal protein bL35 family. (65 aa) |
| | rplT | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (118 aa) |
| | rpsT | 30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (86 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (355 aa) |
| | rplM | 50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (139 aa) |
| | rpsI | Pfam match to PF00380 Ribosomal_S9, score 166, E-value 8.9E-047; Belongs to the universal ribosomal protein uS9 family. (129 aa) |
| | Abu_0110 | Hypothetical protein. (527 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (450 aa) |
| | carA | Carbamoylphosphate synthase, small subunit; Pfam matches to PF00988 CPSase_sm_chain, score 234.8, E-value 1.7E-067, and to PF00117 GATase, score 169.1, E-value 1E-047; Belongs to the CarA family. (372 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (416 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase; Pfam matches to PF00586 AIRS, score 206.2, E-value 6.8E-059, and to PF02769 AIRS_C, score 126.9, E-value 5.1E-035. (331 aa) |
| | speE | Spermidine synthase; Pfam match to PF01564 Spermine_synth, score 19.5, E-value 8.3E-006. (182 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (196 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (389 aa) |
| | rpmE | 50S ribosomal protein L31; Binds the 23S rRNA. (67 aa) |
| | Abu_0165 | Hypothetical protein; Pfam match to PF01253 SUI1, score 33.1, E-value 2E-007. (115 aa) |
| | thiG | Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (259 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (341 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (272 aa) |
| | gatC | glutamyl-tRNA(Gln) amidotransferase, subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (96 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] (373 aa) |
| | Abu_0240 | Conserved hypothetical protein; Pfam match to PF06144 DNA_pol3_delta, score -22.1, E-value 6E-005. (326 aa) |
| | rpsF | 30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (118 aa) |
| | rpsR | 30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (88 aa) |
| | cysS | cysteinyl-tRNA synthetase; Pfam match to PF01406 tRNA-synt_1e, score 541.3, E-value 9.1E-160; Belongs to the class-I aminoacyl-tRNA synthetase family. (467 aa) |
| | nusA | Transcription termination factor NusA; Participates in both transcription termination and antitermination. (391 aa) |
| | Abu_0256 | Conserved hypothetical protein; Pfam match to PF02597 ThiS, score 58, E-value 2.9E-014. (66 aa) |
| | pyrB | Aspartate carbamoyltransferase; Pfam matches to PF02729 OTCace_N, score 168.9, E-value 1.1E-047, and to PF00185 OTCace, score 72.9, E-value 9E-019; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (295 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (312 aa) |
| | dnaX | DNA polymerase III, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (643 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (440 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa) |
| | rpmF | Pfam match to PF01783 Ribosomal_L32p, score 34.1, E-value 4E-003; Belongs to the bacterial ribosomal protein bL32 family. (50 aa) |
| | coaX | Transcriptional activator, putative, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (214 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (321 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (412 aa) |
| | cysG | Uroporphyrin III C-methyltransferase; Pfam match to PF00590 TP_methylase, score 265.7, E-value 8.7E-077; non-fusion protein; does not contain precorrin-2 dehydrogenase or sirohydrochlorin ferrochelatase activity; Belongs to the precorrin methyltransferase family. (243 aa) |
| | Abu_0368 | Glycosyltransferase, putative; Pfam match to PF02885 Glycos_trans_3N, score 51.9, E-value 2E-012. (305 aa) |
| | rpsO | 30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (90 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (432 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (568 aa) |
| | leuS | leucyl-tRNA synthetase; Pfam match to PF00133 tRNA-synt_1, score 62.3, E-value 3.5E-017; Belongs to the class-I aminoacyl-tRNA synthetase family. (821 aa) |
| | folC | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase. (390 aa) |
| | Abu_0416 | Conserved hypothetical protein; Pfam match to PF03486 HI0933_like, score 248.6, E-value 1.2E-071. (368 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa) |
| | accD | acetyl-CoA carboxylase, carboxyltransferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (287 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Pfam match to PF02581 TMP-TENI, score 60.4, E-value 4.3E-020. (203 aa) |
| | lepA | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (595 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Pfam match to PF01288 HPPK, score 123.9, E-value 4.1E-034. (161 aa) |
| | ackA1 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (404 aa) |
| | ackA2 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (396 aa) |
| | ackA3 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (396 aa) |
| | Abu_0517 | CinA-like protein; Pfam match to PF02464 CinA, score 209.8, E-value 5.7E-060; Belongs to the CinA family. (168 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (919 aa) |
| | rpsB | Pfam match to PF00318 Ribosomal_S2, score 343.1, E-value 4.3E-100; Belongs to the universal ribosomal protein uS2 family. (265 aa) |
| | tsf | Translation elongation factor EF-Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (348 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (205 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (309 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (871 aa) |
| | accC2 | Acetyl CoA carboxylase, biotin carboxylase subunit; Pfam matches to PF02786 CPSase_L_D2, score 350.1, E-value 3.4E-102, and to PF02785 Biotin_carb_C, score 211.5, E-value 1.7E-060, and to PF00289 CPSase_L_chain, score 135.4, E-value 1.4E-037. (483 aa) |
| | Abu_0628 | Hypothetical protein. (365 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa) |
| | rplY | 50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (178 aa) |
| | pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (183 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (402 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (72 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (235 aa) |
| | pdxA | Pyridoxal phosphate biosynthetic protein A; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (311 aa) |
| | pdxJ | Pyridoxal phosphate biosynthesis protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (261 aa) |
| | lysS | lysyl-tRNA synthetase; Pfam matches to PF00152 tRNA-synt_2, score 380.5, E-value 2.4E-111, and to PF01336 tRNA_anti, score 65.5, E-value 1.6E-016; Belongs to the class-II aminoacyl-tRNA synthetase family. (504 aa) |
| | dnaB | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (480 aa) |
| | ugd | UDP-glucose 6-dehydrogenase; Pfam matches to PF03721 UDPG_MGDP_dh_N, score 182.6, E-value 8.9E-052, and to PF00984 UDPG_MGDP_dh, score 132.5, E-value 1.1E-036, and to PF03720 UDPG_MGDP_dh_C, score 27, E-value 2.1E-006. (388 aa) |
| | Abu_0660 | NAD-dependent epimerase/dehydratase family protein; Pfam match to PF01370 Epimerase, score 214.5, E-value 2.2E-061. (363 aa) |
| | Abu_0663 | Conserved hypothetical protein. (192 aa) |
| | Abu_0666 | NAD-dependent epimerase/dehydratase family protein; Pfam match to PF01370 Epimerase, score 220.8, E-value 2.7E-063. (335 aa) |
| | Abu_0695 | Putative hexose epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (190 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (185 aa) |
| | trpB1 | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (402 aa) |
| | thiL | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (273 aa) |
| | rpsJ | 30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (104 aa) |
| | rplC | Pfam match to PF00297 Ribosomal_L3, score 56.2, E-value 9.6E-014. (191 aa) |
| | rplD | 50S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (203 aa) |
| | rplW | 50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (93 aa) |
| | rplB | 50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (275 aa) |
| | rpsS | 30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (91 aa) |
| | rplV | 50S ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (110 aa) |
| | rpsC | 30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (234 aa) |
| | rplP | 50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (141 aa) |
| | rpmC | Pfam match to PF00831 Ribosomal_L29, score 50.1, E-value 6.9E-012; Belongs to the universal ribosomal protein uL29 family. (63 aa) |
| | rpsQ | 30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (83 aa) |
| | rplN | 50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rplX | 50S ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (79 aa) |
| | rplE | 50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (185 aa) |
| | rpsN | 30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa) |
| | rpsH | 30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa) |
| | rplF | 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa) |
| | rplR | 50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (119 aa) |
| | rpsE | 30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (146 aa) |
| | rplO | 50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (132 aa) |
| | infA | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (589 aa) |
| | adk1 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (213 aa) |
| | adk2 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (189 aa) |
| | Abu_0781 | Molybdopterin binding domain protein; Pfam match to PF00994 MoCF_biosynth, score 52.3, E-value 6E-015. (255 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Pfam match to PF00218 IGPS, score 373.5, E-value 3E-109; Belongs to the TrpC family. (263 aa) |
| | dnaQ3 | DNA polymerase III; Pfam match to PF00929 Exonuc_X-T, score 128.2, E-value 2.1E-035. (272 aa) |
| | trpF | N-(5'phosphoribosyl)anthranilate isomerase; Pfam match to PF00697 PRAI, score 130.6, E-value 3.9E-036; Belongs to the TrpF family. (197 aa) |
| | Abu_0867 | Putative nucleotide phosphoribosyltransferase; Pfam match to PF00156 Pribosyltran, score 36.6, E-value 8E-008. (148 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (352 aa) |
| | Abu_0891 | Putative 5-formyltetrahydrofolate cyclo-ligase; Pfam match to PF01812 5-FTHF_cyc-lig, score 73.7, E-value 5.3E-019; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (178 aa) |
| | Abu_0906 | Molybdenum transport system protein ModD, putative; Pfam matches to PF01729 QRPTase_C, score 112, E-value 1.6E-030, and to PF02749 QRPTase_N, score 38.1, E-value 2.7E-008; Belongs to the NadC/ModD family. (281 aa) |
| | Abu_0909 | ABC transporter, ATP-binding protein; Pfam match to PF00005 ABC_tran, score 169.8, E-value 6.1E-048. (649 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (511 aa) |
| | nadB | L-aspartate oxidase; Pfam match to PF00890 FAD_binding_2, score 229, E-value 9.4E-066. (483 aa) |
| | cyaA | Adenylate/guanylate cyclase; Pfam matches to PF00211 Guanylate_cyc, score 119.1, E-value 1.2E-032, and to PF05226 CHASE2, score 109.4, E-value 9.4E-030. (723 aa) |
| | ggt | Gamma-glutamyltranspeptidase; Pfam match to PF01019 G_glu_transpept, score 637.4, E-value 1.1E-188. (585 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (603 aa) |
| | hisS | histidyl-tRNA synthetase; Pfam match to PF00587 tRNA-synt_2b, score 142.1, E-value 7E-041. (413 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (189 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa) |
| | rplI | 50S ribosomal protein L9; Binds to the 23S rRNA. (148 aa) |
| | Abu_0983 | Sigma factor, ECF family; Pfam matches to PF08281 Sigma70_r4_2, score 61.6, E-value 3.4E-017, and to PF04542 Sigma70_r2, score 32, E-value 1.9E-006; Belongs to the sigma-70 factor family. ECF subfamily. (158 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminomutase; Pfam match to PF00202 Aminotran_3, score 304.1, E-value 2.4E-088. (426 aa) |
| | rpoD | RNA polymerase sigma 70 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (626 aa) |
| | rpmJ | Pfam match to PF00444 Ribosomal_L36, score 34.9, E-value 2E-003; Belongs to the bacterial ribosomal protein bL36 family. (37 aa) |
| | rpsM | 30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (122 aa) |
| | rpsK | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (130 aa) |
| | rpsD | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (208 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (332 aa) |
| | rplQ | Pfam match to PF01196 Ribosomal_L17, score 153.2, E-value 6.3E-043. (116 aa) |
| | gatA | glutamyl-tRNA(Gln) amidotransferase, subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (453 aa) |
| | guaB | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (481 aa) |
| | Abu_1040 | Sigma factor, ECF family; Pfam match to PF08281 Sigma70_r4_2, score 50.3, E-value 6.8E-014; Belongs to the sigma-70 factor family. ECF subfamily. (159 aa) |
| | Abu_1064 | ABC transporter, ATP-binding protein; Pfam match to PF00005 ABC_tran, score 156.9, E-value 4.8E-044. (532 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (277 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (204 aa) |
| | Abu_1140 | ABC transporter, ATP-binding protein; Pfam match to PF00005 ABC_tran, score 82.3, E-value 1E-016. (495 aa) |
| | hemD | Putative uroporphyrinogen III cosynthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (209 aa) |
| | purD | Phosphoribosylamine-glycine ligase; Pfam matches to PF01071 GARS_A, score 364.2, E-value 1.9E-106, and to PF02844 GARS_N, score 120.8, E-value 3.5E-033, and to PF02843 GARS_C, score 105.5, E-value 1.4E-028; Belongs to the GARS family. (420 aa) |
| | Abu_1192 | Conserved hypothetical protein; Pfam match to PF01903 CbiX, score 93.5, E-value 2.7E-026. (114 aa) |
| | hemN1 | Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (357 aa) |
| | folP | Dihydropteroate synthase; Pfam match to PF00809 Pterin_bind, score 285.7, E-value 8.1E-083. (379 aa) |
| | gltX2 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (433 aa) |
| | metS | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (650 aa) |
| | ribAB | Bifunctional GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (343 aa) |
| | glyS | glycyl-tRNA synthetase, beta chain; Pfam match to PF02092 tRNA_synt_2f, score 683.4, E-value 1.6E-202. (671 aa) |
| | ribA | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (191 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase; Pfam match to PF00490 ALAD, score 616.6, E-value 2E-182; Belongs to the ALAD family. (324 aa) |
| | hemN2 | Oxygen-independent coproporphyrinogen III oxidase; Pfam matches to PF06969 HemN_C, score 134.4, E-value 2.9E-037, and to PF04055 Radical_SAM, score 106.9, E-value 5.6E-029; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (455 aa) |
| | nadE | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (254 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (340 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (896 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (327 aa) |
| | trpB2 | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa) |
| | carB | Carbamoylphosphate synthase, large subunit; Pfam matches to PF02786 CPSase_L_D2, score 376.7, E-value 3.4E-110, and to PF00289 CPSase_L_chain, score 176.2, E-value 7.2E-050, and to PF02787 CPSase_L_D3, score 175.1, E-value 1.6E-049, and to PF02142 MGS, score 103.5, E-value 5.9E-028, and to PF02786 CPSase_L_D2, score 76.2, E-value 1.7E-021, and to PF00289 CPSase_L_chain, score 81.2, E-value 2.9E-021, and to PF02786 CPSase_L_D2, score 43.2, E-value 4.3E-012; Belongs to the CarB family. (1081 aa) |
| | Abu_1390 | ABC transporter, ATP-binding protein; Pfam match to PF00005 ABC_tran, score 150, E-value 5.6E-042. (578 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (615 aa) |
| | Abu_1412 | HI0933-like protein; Pfam match to PF03486 HI0933_like, score 402.1, E-value 7.2E-118. (411 aa) |
| | thiI | Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (488 aa) |
| | Abu_1430 | Sigma factor, ECF family; Pfam match to PF08281 Sigma70_r4_2, score 33.9, E-value 4.4E-009; Belongs to the sigma-70 factor family. ECF subfamily. (158 aa) |
| | Abu_1452 | Sigma factor, ECF family; Pfam matches to PF08281 Sigma70_r4_2, score 46.6, E-value 8.1E-013, and to PF04542 Sigma70_r2, score 27.3, E-value 4.9E-005; Belongs to the sigma-70 factor family. ECF subfamily. (157 aa) |
| | dinP | DNA polymerase IV; Pfam match to PF00817 IMS, score 111.8, E-value 1.9E-030. (421 aa) |
| | selA | L-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (451 aa) |
| | selB | Selenocysteine-specific elongation factor; Pfam match to PF00009 GTP_EFTU, score 116.5, E-value 7.2E-032. (609 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (212 aa) |
| | Abu_1557 | Conserved hypothetical membrane protein (DUF6); Pfam match to PF00892 DUF6, score 64.7, E-value 2.8E-016; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (155 aa) |
| | Abu_1568 | Sigma factor, ECF family; Pfam matches to PF08281 Sigma70_r4_2, score 49, E-value 1.7E-013, and to PF04542 Sigma70_r2, score 36.8, E-value 6.9E-008; Belongs to the sigma-70 factor family. ECF subfamily. (157 aa) |
| | atpC | ATP synthase F1 sector, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (125 aa) |
| | atpD | ATP synthase F1 sector, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (464 aa) |
| | atpG | ATP synthase F1 sector, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (295 aa) |
| | atpA | ATP synthase F1 sector, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (505 aa) |
| | atpH | ATP synthase F1 sector, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (176 aa) |
| | atpF | ATP synthase F0 sector, subunit B; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (170 aa) |
| | atpF-2 | ATP synthase F0 sector, B' subunit; Pfam match to PF00430 ATP-synt_B, score 30.8, E-value 4.3E-006; Belongs to the ATPase B chain family. (140 aa) |
| | fmt | 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (306 aa) |
| | rpmA | Pfam match to PF01016 Ribosomal_L27, score 189.8, E-value 5.8E-054; Belongs to the bacterial ribosomal protein bL27 family. (85 aa) |
| | rplU | 50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (105 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (544 aa) |
| | rpmH | Pfam match to PF00468 Ribosomal_L34, score 72.6, E-value 1.2E-018; Belongs to the bacterial ribosomal protein bL34 family. (44 aa) |
| | bioA | 7,8-diaminopelargonic acid synthetase; Pfam match to PF00202 Aminotran_3, score 446.9, E-value 2.4E-131; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa) |
| | purH | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase; Pfam matches to PF01808 AICARFT_IMPCHas, score 301.2, E-value 6.9E-091, and to PF02142 MGS, score 179.3, E-value 8.4E-051. (510 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (737 aa) |
| | folE | Pfam match to PF01227 GTP_cyclohydroI, score 179.3, E-value 8.6E-051. (190 aa) |
| | Abu_1664 | Baseplate assembly protein V, putative; Pfam match to PF04717 Phage_base_V, score 63.3, E-value 7.1E-016. (243 aa) |
| | def | Polypeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (171 aa) |
| | nspC | Carboxynorspermidine decarboxylase; Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine; Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily. (381 aa) |
| | Abu_1706 | Saccharopine dehydrogenase (L-lysine-forming); Pfam match to PF03435 Saccharop_dh, score 564.4, E-value 1E-166. (400 aa) |
| | Abu_1714 | ATPase, putative. (604 aa) |
| | atpE | ATP synthase F0 sector, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (104 aa) |
| | thiD | Phosphomethylpyrimidine kinase; Pfam match to PF08543 Phos_pyr_kin, score 324.9, E-value 1.3E-094. (251 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (246 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (269 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (346 aa) |
| | rpmB | Pfam match to PF00830 Ribosomal_L28, score 83.2, E-value 7.3E-022; Belongs to the bacterial ribosomal protein bL28 family. (62 aa) |
| | Abu_1795 | Putative heptose phosphatase; Possible pseudogene/truncated protein. G:A transition (Met:Ile) at bp 1795888 results in a potential start codon shift to bp 1796039. N-terminal sequence downstream of putatively mutated start codon at 1795886 corresponds to N-terminal sequences of similar protein in P. haloplanktis. Good RBS present at bp 1795874-1795879. (122 aa) |
| | waaE | ADP-heptose synthase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family. (478 aa) |
| | Abu_1829 | Conserved hypothetical protein. (261 aa) |
| | ribF | Bifunctional riboflavin kinase/FAD synthase RibF; Pfam matches to PF01687 Flavokinase, score 95.1, E-value 1.9E-025, and to PF06574 FAD_syn, score 28.7, E-value 1.1E-009; Belongs to the ribF family. (281 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (422 aa) |
| | ribH | Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (156 aa) |
| | nusB | Transcription termination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (131 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). (232 aa) |
| | Abu_1873 | Replication protein; Pfam match to PF01051 Rep_3, score 110.7, E-value 4E-030. (264 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1511 aa) |
| | rpoB | DNA-directed RNA polymerase, beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1382 aa) |
| | rplL | 50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (123 aa) |
| | rplJ | 50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (162 aa) |
| | rplA | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (232 aa) |
| | rplK | 50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa) |
| | nusG | Transcription termination factor NusG; Participates in transcription elongation, termination and antitermination. (175 aa) |
| | rpmG | Pfam match to PF00471 Ribosomal_L33, score 64.3, E-value 3.6E-016; Belongs to the bacterial ribosomal protein bL33 family. (56 aa) |
| | tufA | Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (402 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (212 aa) |
| | Abu_1925 | AMP-dependent synthetase and ligase; Pfam matches to PF00501 AMP-binding, score 380.6, E-value 2.2E-111, and to PF03328 HpcH_HpaI, score 82.5, E-value 7.9E-023; Belongs to the HpcH/HpaI aldolase family. (839 aa) |
| | fliI | Flagellum-specific ATP synthase FliI; Pfam match to PF00006 ATP-synt_ab, score 406.1, E-value 2.2E-121. (435 aa) |
| | rpsP | Pfam match to PF00886 Ribosomal_S16, score 121.7, E-value 1.9E-033; Belongs to the bacterial ribosomal protein bS16 family. (75 aa) |
| | Abu_1978 | Conserved hypothetical protein; Pfam match to PF01784 NIF3, score 193.2, E-value 5.6E-055. (251 aa) |
| | glyQ | glycyl-tRNA synthetase, alpha chain; Pfam match to PF02091 tRNA-synt_2e, score 728.5, E-value 4.1E-216. (293 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (164 aa) |
| | nadK | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (288 aa) |
| | fus | Translational elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 [...] (702 aa) |
| | rpsG | 30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (155 aa) |
| | rpsL | 30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (127 aa) |
| | rplS | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (118 aa) |
| | atpB | ATP synthase F0 sector, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (228 aa) |
| | Abu_2031 | Thiamine monophosphate synthase; Pfam match to PF02581 TMP-TENI, score 38.7, E-value 7.9E-013. (184 aa) |
| | nadA | Quinolinate synthetase A protein; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (329 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase; Pfam matches to PF01729 QRPTase_C, score 287.4, E-value 2.5E-083, and to PF02749 QRPTase_N, score 81.9, E-value 1.9E-021; Belongs to the NadC/ModD family. (273 aa) |
| | infB | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (890 aa) |
| | ribD | Bifunctional riboflavin biosynthesis protein RibD; Pfam match to PF00383 dCMP_cyt_deam_1, score 117.5, E-value 3.5E-032. (334 aa) |
| | efp | Translation elongation factor EF-P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (186 aa) |
| | rpsA | 30S ribosomal protein S1; Pfam match to PF00575 S1, score 95.4, E-value 1.5E-025. (550 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit; Pfam matches to PF01588 tRNA_bind, score 115.8, E-value 1.1E-031, and to PF03147 FDX-ACB, score 100.1, E-value 5.8E-027, and to PF03484 B5, score 74.4, E-value 3.4E-019; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (774 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit; Pfam matches to PF01409 tRNA-synt_2d, score 491.8, E-value 7.2E-145, and to PF02912 Phe_tRNA-synt_N, score 79.2, E-value 1.1E-020; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (330 aa) |
| | accA | acetyl-CoA carboxylase, carboxyltransferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (311 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (254 aa) |
| | Abu_2060 | Conserved hypothetical protein. (174 aa) |
| | exsB | Transcriptional regulator, ExsB family; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (228 aa) |
| | prfB | Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (365 aa) |
| | smpB | tmRNA-binding protein SmpB; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switc [...] (158 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (448 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (851 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Pfam match to PF01259 SAICAR_synt, score 73.6, E-value 5.8E-019. (317 aa) |
| | purS | Phosphoribosylformylglycinamidine synthetase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (81 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (223 aa) |
| | argS | arginyl-tRNA synthetase; Pfam matches to PF00750 tRNA-synt_1d, score 242.5, E-value 8.3E-070, and to PF03485 Arg_tRNA_synt_N, score 100.1, E-value 5.9E-027, and to PF05746 tRNA-synt_1d_C, score 94.6, E-value 2.6E-025. (529 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (182 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (601 aa) |
| | Abu_2142 | Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (316 aa) |
| | Abu_2146 | Conserved hypothetical protein. (115 aa) |
| | Abu_2165 | Sigma factor, ECF family; Pfam matches to PF08281 Sigma70_r4_2, score 62.6, E-value 1.7E-017, and to PF04542 Sigma70_r2, score 40.8, E-value 4.4E-009; Belongs to the sigma-70 factor family. ECF subfamily. (159 aa) |
| | Abu_2167 | HI0933-like protein; Pfam match to PF03486 HI0933_like, score 351.2, E-value 1.5E-102. (409 aa) |
| | Abu_2177 | Hypothetical protein. (432 aa) |
| | cobS | Cobalamin (Vitamin B12) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (248 aa) |
| | cobP | Bifunctional cobinamide kinase / Cobinamide phosphate guanylyltransferase. (164 aa) |
| | Abu_2184 | Conserved hypothetical protein; Pfam match to PF02277 DBI_PRT, score -33, E-value 1.1E-008. (355 aa) |
| | rimK | Ribosomal protein S6 modification protein; Pfam match to PF08443 RimK, score 283.6, E-value 3.5E-082; Belongs to the RimK family. (309 aa) |
| | dfp | Bifunctional DNA /pantothenate metabolism flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (407 aa) |
| | glmU | Bifunctional UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (432 aa) |
| | ribE | Riboflavin synthase, alpha subunit; Pfam match to PF00677 Lum_binding, score 126, E-value 1.7E-037. (203 aa) |
| | queH | Conserved hypothetical protein (DUF208 domain protein); Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (357 aa) |
| | bioB | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (282 aa) |
| | Abu_2250 | ATP-grasp (A) domain protein; Pfam match to PF02222 ATP-grasp, score 26.3, E-value 5.8E-008. (373 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (538 aa) |
| | dnaE | DNA polymerase III, alpha subunit; Pfam matches to PF07733 DNA_pol3_alpha, score 935.2, E-value 2.4E-278, and to PF02811 PHP, score 255.4, E-value 9.8E-075. (1187 aa) |
| | rpsU | Pfam match to PF01165 Ribosomal_S21, score 99.7, E-value 7.7E-027; Belongs to the bacterial ribosomal protein bS21 family. (73 aa) |
| | Abu_2274 | Conserved hypothetical protein. (135 aa) |
| | frr | Ribosome releasing factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (204 aa) |
| | Abu_2316 | Sigma factor, ECF family; Pfam matches to PF08281 Sigma70_r4_2, score 59.8, E-value 1.1E-016, and to PF04542 Sigma70_r2, score 26.7, E-value 7.4E-005; Belongs to the sigma-70 factor family. ECF subfamily. (159 aa) |
| | thyX | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (275 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Pfam match to PF00551 Formyl_trans_N, score 120.3, E-value 4.9E-033. (192 aa) |
