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| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the formation of aspartate semialdehydefrom aspartyl phosphate; Orthologue of BL0492; Belongs to the aspartate-semialdehyde dehydrogenase family. (364 aa) |
| | BAD_0319 | Acetaldehyde dehydrogenase; Orthologue of ECs1741; Similar to ADHE_ECOLI gi|1787493 (conserved in Escherichia coli K-12); In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (910 aa) |
| | BAD_0305 | Possible 2-hydroxyacid dehydrogenase; COG family: phosphoglycerate dehydrogenase andrelated dehydrogenases; Orthologue of BL1568; PFAM_ID: 2-Hacid_DH_C; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa) |
| | BAD_0313 | Orthologue of SCO1901; Probable zinc-binding dehydrogenase. (334 aa) |
| | BAD_0317 | Xylitol (sorbitol) dehydrogenase; Orthologue of mlr4915. (368 aa) |
| | BAD_0387 | Hypothetical protein; Orthologue of BL1664a. (137 aa) |
| | dfrA | COG family: dihydrofolate reductase; Orthologue of BL1666; PFAM_ID:DiHfolate_red; Belongs to the dihydrofolate reductase family. (224 aa) |
| | fucO | Possible lactaldehyde reductase; COG family:alcohol dehydrogenase IV; Orthologue of BL1673; PFAM_ID: Fe-ADH; Propanediol oxidoreductase. (383 aa) |
| | ribD | Riboflavin biosynthesis protein RibD; Orthologue of SAK_0872; identified by similarity to SP:P17618. (317 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (514 aa) |
| | badC | Alcohol dehydrogenase; COG family: NADPH; Orthologue of BL1131; PFAM_ID: adh_zinc; Quinone oxidoreductase. (333 aa) |
| | BAD_0550 | Hypothetical protein; Orthologue of BL1086. (266 aa) |
| | BAD_0592 | Probable iron sulfur protein associated with succinate dehydrogenase; COG family: succinate dehydrogenase_fumaratereductase Fe-S protein; Orthologue of BL0939; fumarate reductase. (305 aa) |
| | sdhA | COG family: succinate dehydrogenase_fumaratereductase_ flavoprotein subunits; Orthologue of BL0938; PFAM_ID: FAD_binding_2; PFAM_ID: succ_DH_flav_C. (618 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (266 aa) |
| | BAD_0622 | Hypothetical protein; COG family: dehydrogenases with differentspecificities (related to short-chain alcoholdehydrogenases); Orthologue of BL0690; PFAM_ID: adh_short. (236 aa) |
| | gnt | 6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (487 aa) |
| | zwf2 | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (520 aa) |
| | BAD_0637 | Possible NAD(P)H oxidoreductase; COG family: putative NADPH-quinone reductase(modulator of drug activity B); Orthologue of BL1749; PFAM_ID: NADHdh_2. (171 aa) |
| | folD | Bifunctional methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (291 aa) |
| | pntA | COG family: NAD_NADP transhydrogenase alphasubunit; Orthologue of BL0857; PFAM_ID: AlaDh_PNT; Pyridine nucleotide transhydrogenase subunit alpha1. (381 aa) |
| | pntB | NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (481 aa) |
| | BAD_0730 | Hypothetical protein. (132 aa) |
| | hemN | Probable oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (387 aa) |
| | gltB | Glutamate synthase [NADPH] large subunit; Orthologue of Rv3859c_BL0834; ProbablegltB_ ferredoxin-dependent glutamate synthase largesubunit (EC 1.4.1.13). (1548 aa) |
| | gltD | Glutamate synthase [NADPH] small subunit; COG family: NADPH-dependent glutamatesynthase beta chain and related oxidoreductases; Orthologue of BL0833; PFAM_ID: pyr_redox; PFAM_ID:FAD_binding_3. (515 aa) |
| | metF | COG family: 5_10-methylenetetrahydrofolatereductase; Orthologue of BL0797; PFAM_ID: MTHFR; Belongs to the methylenetetrahydrofolate reductase family. (279 aa) |
| | pyrK | Probable dihydroorotate dehydrogenase electron transfer subunit; COG family: 2-polyprenylphenolhydroxylase and related flavodoxin oxidoreductases; Orthologue of BL0790; PFAM_ID: FAD_binding_6. (272 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (315 aa) |
| | icd1 | COG family: isocitrate dehydrogenases; Orthologue of BL1499; Oxalosuccinate decarboxylase; PFAM_ID: isodh; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (406 aa) |
| | BAD_0777 | GMP reductase; COG family: IMP dehydrogenase_GMP reductase; Orthologue of BL1500; PFAM_ID: IMPDH_C; PFAM_ID: IMPDH_N. (379 aa) |
| | BAD_0824 | Hypothetical protein; Orthologue of BL0722. (275 aa) |
| | aroE | COG family: shikimate 5-dehydrogenase; Orthologue of BL0704; PFAM_ID: Shikimate_DH. (312 aa) |
| | BAD_0854 | Putative carboxymuconolactone decarboxylase; Orthologue of LBA0464. (267 aa) |
| | BAD_0873 | COG family: predicted oxidoreductases (related toaryl-alcohol dehydrogenases); Orthologue of BL0290; PFAM_ID: aldo_ket_red. (335 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (427 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (378 aa) |
| | BAD_0934 | Possible acyl-CoA reductase; Orthologue of BL0513. (504 aa) |
| | BAD_0935 | 3-oxoacyl-[acyl-carrier protein] reductase; 3-ketoacyl-acyl carrier protein reductase; COGfamily: dehydrogenases with different specificities(related to short-chain alcohol dehydrogenases); Orthologue of BL0512; PFAM_ID:adh_short. (264 aa) |
| | pdhD | COG family: dihydrolipoamidedehydrogenase_glutathio ne oxidoreductase and relatedenzymes; Orthologue of BL1074; PFAM_ID: pyr_redox. (507 aa) |
| | pflA | Pyruvate formate-lyase 1 activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (292 aa) |
| | tyrA | COG family: prephenate dehydrogenase; Orthologue of BL1382; PFAM_ID: PDH. (346 aa) |
| | gap | COG family:glyceraldehyde-3-phosphatedehydrogenase_erythrose- 4-phosphate dehydrogenase; Orthologue of BL1363; PFAM_ID: GpdH; PFAM_ID: gpdh_C; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (351 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (343 aa) |
| | BAD_1098 | Hypothetical protein; COG family: predicted flavin-nucleotide-bindingprotein structurally related to pyridoxine 5'-phosphateoxidase; Orthologue of BL1445. (134 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (403 aa) |
| | ldh2 | L-lactate dehydrogenase 2; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (369 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (511 aa) |
| | BAD_1137 | Possible NifR3-like protein; COG family: predicted TIM-barrel enzymes_ possiblydehydrogenases_ NifR3 family; Orthologue of BL0117; PFAM_ID: UPF0034. (409 aa) |
| | BAD_1142 | Hypothetical protein; Orthologue of lmo2592. (291 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (399 aa) |
| | ispC | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (392 aa) |
| | BAD_1166 | Narrowly conserved hypothetical transmembrane protein; Orthologue of BL0088. (208 aa) |
| | nrdG | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (237 aa) |
| | nrdD | Anaerobic ribonucleoside triphosphate reductase; Catalyzes the reduction of nucleoside5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; Orthologue of HI0075. (801 aa) |
| | BAD_1261 | NAD/NADP octopine/nopaline dehydrogenase; Orthologue of STH257. (144 aa) |
| | BAD_1262 | Hypothetical protein; Orthologue of PP4452. (241 aa) |
| | actP | ActP copper transport ATPase; Orthologue of SMa1013; Silver efflux P-type ATPase [Psychrobacter arcticus 273-4]; Start changed for RBS and homology with other ATPases. (1000 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (287 aa) |
| | BAD_1334 | Dihydroorotate dehydrogenase-like protein; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (337 aa) |
| | baiC | Probable NADH-dependent flavin oxidoreductase YqjM; COG family: NADH; Orthologue of BL1214; PFAM_ID: oxidored_FMN. (373 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (346 aa) |
| | trxA2 | Thioredoxin; COG family: thiol-disulfide isomerase andthioredoxins; Orthologue of BL1226; PFAM_ID: thiored. (134 aa) |
| | BAD_1396 | Dehydrogenase or reductase protein; COG family: aldo_keto reductases_ related todiketogulonate reductase; Orthologue of BL0255; PFAM_ID: aldo_ket_red. (284 aa) |
| | thrA | COG family: homoserine dehydrogenase; Orthologue of BL1274; PFAM_ID: ACT; PFAM_ID: Homoserine_dh. (438 aa) |
| | BAD_1421 | Hypothetical protein; COG family: thioredoxin domain-containing protein; Orthologue of BL0350. (346 aa) |
| | BAD_1455 | Hypothetical protein; COG family: protoporphyrinogen oxidase; Orthologue of BL0399. (529 aa) |
| | silP | COG family: cation transport ATPases; Orthologue of BL0409; PFAM_ID: E1-E2_ATPase; PFAM_ID: Hydrolase. (311 aa) |
| | rmlCD | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (476 aa) |
| | BAD_1568 | Possible NADPH-flavin oxidoreductase; COG family: nitroreductase; Flavin reductase P; NADPH-Fmn oxidoreductase; Orthologue of BL0139; PFAM_ID:Nitroreductase; Belongs to the flavin oxidoreductase frp family. (259 aa) |
| | trxB | COG family: thioredoxin reductase; Orthologue of BL0649; PFAM_ID:pyr_redox; TrxB_ thioredoxin reductase (NADPH)_len: 322 aa; previously sequenced as SW:TRXB_STRCO(EMBL:AJ007313)_ TrxB. Contains PS00573 Pyridinenucleotide-disulphide oxidoreductases class-II active site. (313 aa) |
| | gdhA | COG0334; Converts 2-oxoglutarate to glutamate; In Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; Leucine dehydrogenase; Orthologue of BL0630; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (448 aa) |
| | fprA | Probable ferredoxin/ferredoxin-NADP reductase; COG family: NADPH-dependent glutamatesynthase beta chain and related oxidoreductases; Orthologue of BL0552; PFAM_ID:pyr_redox. (486 aa) |
| | ilvC2 | Ketol-acid reductoisomerase 2; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (368 aa) |
| | ilvC1 | Ketol-acid reductoisomerase 1; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (346 aa) |
| | BAD_0091 | Possible oxidoreductase in aldo-keto reductase family; Orthologue of BL1023. (352 aa) |
| | BAD_0095 | Oxidoreductase; Orthologue of lp_3100. (326 aa) |
| | BAD_0182 | Hypothetical protein; COG family: dihydroorotate dehydrogenase; Orthologue of BL1265; PFAM_ID:DHOdehase. (380 aa) |
| | gpsA | COG family: glycerol 3-phosphate dehydrogenase; NAD(P)H-dependent dihydroxyacetone-phosphatereductase; Orthologue of BL0346; PFAM_ID: NAD_Gly3P_dh; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (332 aa) |
| | BAD_0197 | Putative 6-phosphogluconate dehydrogenase; Catalyzes the formation of D-ribulose 5-phosphatefrom 6-phospho-D-gluconate; Orthologue of SCO3877. (297 aa) |
| | fas | Orthologue of Rv2524c_BL1537; Probable fas_ Fatty Acid Synthase (EC 2.3.1.-). (3111 aa) |
| | BAD_0264 | COG family: predicted oxidoreductases (related toaryl-alcohol dehydrogenases); Orthologue of BL0309. (287 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (356 aa) |
| | fdxC | Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (106 aa) |
