STRINGSTRING
clpB clpB BAD_1465 BAD_1465 BAD_1519 BAD_1519 mesJ mesJ leuA leuA fhs fhs BAD_0235 BAD_0235 BAD_0264 BAD_0264 BAD_0287 BAD_0287 BAD_0313 BAD_0313 BAD_0317 BAD_0317 rplP rplP rpsM rpsM truA truA ribF ribF serC serC BAD_0421 BAD_0421 BAD_0486 BAD_0486 BAD_0510 BAD_0510 ispE ispE purD purD purF purF rpsL rpsL BAD_0550 BAD_0550 clpC1 clpC1 BAD_0584 BAD_0584 cysD cysD BAD_0603 BAD_0603 ychF ychF BAD_0634 BAD_0634 BAD_0682 BAD_0682 BAD_0701 BAD_0701 BAD_0710 BAD_0710 BAD_0711 BAD_0711 BAD_0712 BAD_0712 ybeY ybeY fadD2 fadD2 BAD_0730 BAD_0730 BAD_0731 BAD_0731 gltB gltB BAD_0755 BAD_0755 metE metE BAD_0772 BAD_0772 fadD4 fadD4 fadD3 fadD3 BAD_0818 BAD_0818 BAD_0847 BAD_0847 BAD_0852 BAD_0852 yxjG_1 yxjG_1 BAD_0872 BAD_0872 BAD_0885 BAD_0885 BAD_0029 BAD_0029 BAD_0892 BAD_0892 BAD_0068 BAD_0068 BAD_0091 BAD_0091 BAD_0102 BAD_0102 BAD_0120 BAD_0120 yoaP yoaP yoaP-2 yoaP-2 nadD nadD argB argB argC argC BAD_0931 BAD_0931 BAD_0936 BAD_0936 BAD_0995 BAD_0995 BAD_1015 BAD_1015 xerC xerC BAD_1064 BAD_1064 pheA pheA gap gap folC folC BAD_1116 BAD_1116 BAD_1164 BAD_1164 BAD_1166 BAD_1166 BAD_1213 BAD_1213 BAD_1230 BAD_1230 BAD_1238 BAD_1238 BAD_1346 BAD_1346 trxA2 trxA2 BAD_1402 BAD_1402 pdxS pdxS fadD1 fadD1 nth nth BAD_1455 BAD_1455
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
clpBChaperone clpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (905 aa)
BAD_1465Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase in the fumarylacetoacetate hydrolase family; COG family: 2-keto-4-pentenoatehydratase_2-oxohepta-3-ene-1_7-dioic acid hydratase(catechol pathway); Orthologue of BL1247; PFAM_ID: FAA_hydrolase. (273 aa)
BAD_1519Possible ATP binding protein of ABC transporter; COG family: ABC-type sugar (aldose) transportsystem_ ATPase component; COG family: ABC-type transport systems_ involved inlipoprotein release_ permease components; Orthologue of BL0197; PFAM_ID: ABC_tran. (347 aa)
mesJPossible cytidine and deoxycytidylate deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (157 aa)
leuAPossible TetR-type transcriptional regulator; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (636 aa)
fhsFormate-tetrahydrofolate ligase; COG family: formyltetrahydrofolate synthetase; Orthologue of BL0478; PFAM_ID:FTHFS; formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. (527 aa)
BAD_0235COG family: ABC-type transport systems_ involved inlipoprotein release_ ATPase components; Orthologue of BL0932_BL1277; PFAM_ID: ABC_tran. (241 aa)
BAD_0264COG family: predicted oxidoreductases (related toaryl-alcohol dehydrogenases); Orthologue of BL0309. (287 aa)
BAD_0287Hypothetical protein; COG family: superfamily I DNA and RNA helicases andhelicase subunits; Orthologue of BL1552. (1210 aa)
BAD_0313Orthologue of SCO1901; Probable zinc-binding dehydrogenase. (334 aa)
BAD_0317Xylitol (sorbitol) dehydrogenase; Orthologue of mlr4915. (368 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (139 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (136 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (306 aa)
ribFRiboflavin kinase; COGfamily: FAD synthase; Fad pyrophosphorylase; Fad synthetase; Orthologue of BL1619; PFAM_ID: FAD_Synth. (409 aa)
serCProbable phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (380 aa)
BAD_0421O-acetylhomoserine (thiol)-lyase; Orthologue of BT1923. (426 aa)
BAD_0486ABC transporter; ATP-binding protein; Identified by sequence similarity; Orthologue of Lxx18820. (221 aa)
BAD_0510COG family: ABC-type transport systems_ involved inlipoprotein release_ ATPase components; Orthologue of BL1135; PFAM_ID: ABC_tran. (243 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (308 aa)
purDCOG family:phosphoribosylamine-glycine ligase; GarS:glycinamide ribonucleotide synthetase;phosphoribosylglycinamide synthetase; Orthologue of BL1123; PFAM_ID: GARS; Belongs to the GARS family. (420 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (504 aa)
rpsL30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (123 aa)
BAD_0550Hypothetical protein; Orthologue of BL1086. (266 aa)
clpC1Orthologue of Rv3596c_BL0010; ProbableclpC1_ ATP-dependent protease ATP-binding subunit (EC3.4.-.-); Belongs to the ClpA/ClpB family. (864 aa)
BAD_0584Probable DEAD box-like helicase; Orthologue of Tfu_0878_BL0028. (852 aa)
cysDCOG family:O-acetylhomoserine sulfhydrylase; Homocysteine synthase; Oahsulfhydrylase; Orthologue of BL0933; PFAM_ID:Cys_Met_Meta_PP. (436 aa)
BAD_0603Possible ATP binding protein of ABC transporter; COG family: ABC-type transport systems_ involved inlipoprotein release_ ATPase components; Orthologue of BL0932; PFAM_ID: ABC_tran. (263 aa)
ychFWidely conserved hypothetical GTPase-like protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (366 aa)
BAD_0634Putative 6-O-methylguanine DNA methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (217 aa)
BAD_0682Possible pyrophosphate-releasing NTPase in MutT family; COG family: NTP pyrophosphohydrolases includingoxidative damage repair enzymes; Orthologue of BL0983; PFAM_ID: NUDIX; Belongs to the Nudix hydrolase family. (207 aa)
BAD_0701Putative Holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. (151 aa)
BAD_0710Possible ABC transporter component; Orthologue of Tfu_1987_BL0872. (506 aa)
BAD_0711Possible ABC transporter component; COG family: predicted membrane components of anuncharacterized iron-regulated ABC-type transporter SufB; Orthologue of BL0871_Tfu_1987; PFAM_ID: UPF0051. (410 aa)
BAD_0712Probable ATP binding protein of ABC transporter; COG family: iron-regulated ABC transporter ATPasesubunit SufC; Identified by sequence similarity; Orthologue of BL0870; PFAM_ID: ABC_tran. (259 aa)
ybeYHypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (181 aa)
fadD2long-chain-fatty-acid-CoA ligase; COG family: long-chain acyl-CoA synthetases(AMP-forming); Orthologue of BL0858; PFAM_ID: AMP-binding. (678 aa)
BAD_0730Hypothetical protein. (132 aa)
BAD_0731Putative outer membrane protein probably involved in nutrient binding; Orthologue of BF2138; Similar to Mycoplasma penetrans hypothetical protein mype1860. (135 aa)
gltBGlutamate synthase [NADPH] large subunit; Orthologue of Rv3859c_BL0834; ProbablegltB_ ferredoxin-dependent glutamate synthase largesubunit (EC 1.4.1.13). (1548 aa)
BAD_0755Hypothetical protein; Orthologue of BF1907; Similar to Mycoplasma penetrans hypothetical protein mype1860. (150 aa)
metE5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (768 aa)
BAD_0772ABC transporter; ATP-binding protein; Orthologue of SP1653. (233 aa)
fadD4Probable long-chain-fatty-acid--CoA ligase; COG family: long-chain acyl-CoA synthetases(AMP-forming); Orthologue of BL1748; PFAM_ID: AMP-binding. (609 aa)
fadD3Possible long-chain-fatty acid CoA ligase; COG family: long-chain acyl-CoA synthetases(AMP-forming); Orthologue of BL1501; PFAM_ID: AMP-binding. (679 aa)
BAD_0818Probable helicase; Identified by sequence similarity; Orthologue of Lxx08340_BL0742. (882 aa)
BAD_0847Hypothetical protein; Orthologue of PPA1479. (122 aa)
BAD_0852Cation transporter; Identified by sequence similarity; Orthologue of Lxx01710. (341 aa)
yxjG_1Hypothetical protein; Orthologue of CPj0143. (403 aa)
BAD_0872Hypothetical protein; Orthologue of HH0341; Similar to Campylobacter jejuni CJ1254. (179 aa)
BAD_0885Hypothetical protein; COG family: histone acetyltransferase Hpa2 andrelated acetyltransferases; Orthologue of BL0561; PFAM_ID: Acetyltransf. (147 aa)
BAD_0029Hypothetical protein; Orthologue of BL0598. (145 aa)
BAD_0892ATP binding protein of ABC transporter similar to Vex2; COG family: ABC-type transport systems_ involved inlipoprotein release_ ATPase components; Orthologue of BL0267; PFAM_ID: ABC_tran. (211 aa)
BAD_0068Probable voltage gated channel protein; COG family: chloride channel protein EriC; Orthologue of BL0548; PFAM_ID: TrkA; PFAM_ID:voltage_CLC. (575 aa)
BAD_0091Possible oxidoreductase in aldo-keto reductase family; Orthologue of BL1023. (352 aa)
BAD_0102COG family: ABC-type transport systems_ involved inlipoprotein release_ ATPase components; Orthologue of BL0450; PFAM_ID: ABC_tran. (291 aa)
BAD_0120COG family: predicted unusual protein kinase; Orthologue of BL0427; PFAM_ID: ABC1. (501 aa)
yoaPHypothetical protein; Orthologue of BSU18690 N-terminal fragment. (168 aa)
yoaP-2Hypothetical protein. (153 aa)
nadDPossible nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (242 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (318 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (378 aa)
BAD_0931ABC transporter domain protein; Identified by match to protein family HMM PF00005; Orthologue of BCE2757. (276 aa)
BAD_0936Hypothetical protein; Orthologue of gbs1997; Similar to unknown protein; Belongs to the LOG family. (193 aa)
BAD_0995Hypothetical protein; COG family: metal-dependentamidase_aminoacylase_carboxypeptidase; Orthologue of BL0954; PFAM_ID:Peptidase_M20. (382 aa)
BAD_1015Hypothetical protein; COG family: 1-acyl-sn-glycerol-3-phosphateacyltransferase; Orthologue of BL1424; PFAM_ID: Acyltransferase. (242 aa)
xerCProbable integrase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (329 aa)
BAD_1064Putative ABC transporter ATP-binding protein; Orthologue of BL0932_nfa46550. (281 aa)
pheAProbable chorismate mutase; COG family: prephenate dehydratase; Orthologue of BL1381; PFAM_ID: ACT; PFAM_ID:PDT. (326 aa)
gapCOG family:glyceraldehyde-3-phosphatedehydrogenase_erythrose- 4-phosphate dehydrogenase; Orthologue of BL1363; PFAM_ID: GpdH; PFAM_ID: gpdh_C; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (351 aa)
folCCOG family: folylpolyglutamatesynthase; Orthologue of BL1353; PFAM_ID: Mur_ligase. (532 aa)
BAD_1116Probable cation efflux protein; COG family: Co_Zn_Cd efflux system component; Orthologue of BL1309; PFAM_ID: Cation_efflux; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. (313 aa)
BAD_1164Hypothetical protein; Orthologue of BL0091. (523 aa)
BAD_1166Narrowly conserved hypothetical transmembrane protein; Orthologue of BL0088. (208 aa)
BAD_1213Possible glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (432 aa)
BAD_1230Helicase; Orthologue of BCE1021; SNF2 family. (890 aa)
BAD_1238Alpha-mannosidase; Orthologue of SCO0948_BL1327_BL1328_BL1329. (1074 aa)
BAD_1346Hypothetical protein; COG family: NTP pyrophosphohydrolases containing aZn-finger_ probably nucleic-acid-binding; Orthologue of BL1222; PFAM_ID: NUDIX. (365 aa)
trxA2Thioredoxin; COG family: thiol-disulfide isomerase andthioredoxins; Orthologue of BL1226; PFAM_ID: thiored. (134 aa)
BAD_1402Beta-galactosidase precursor; Orthologue of BT4160; Belongs to the glycosyl hydrolase 35 family. (751 aa)
pdxSPyridoxal biosynthesis lyase pdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (291 aa)
fadD1Probable long-chain-fatty acid CoA ligase; COG family: long-chain acyl-CoA synthetases(AMP-forming); Orthologue of BL0266; PFAM_ID: AMP-binding. (607 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (221 aa)
BAD_1455Hypothetical protein; COG family: protoporphyrinogen oxidase; Orthologue of BL0399. (529 aa)
Your Current Organism:
Bifidobacterium adolescentis
NCBI taxonomy Id: 367928
Other names: B. adolescentis ATCC 15703, Bifidobacterium adolescentis ATCC 15703, Bifidobacterium adolescentis str. ATCC 15703, Bifidobacterium adolescentis strain ATCC 15703
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