(45 nodes) Wnt signaling pathway, and Pectinacetylesterase network (Kryptolebias marmoratus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108250227	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	ENSKMAP00000000736	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (561 aa)
	wls	Wnt ligand secretion mediator. (546 aa)
	fzd6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (691 aa)
	fzd9	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (584 aa)
	fzd3	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family. (696 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (254 aa)
	wnt9a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	LOC108249203	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	sfrp2	Secreted frizzled-related protein 2. (308 aa)
	porcn	Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (448 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (545 aa)
	LOC108248723	Secreted frizzled-related protein 1a. (297 aa)
	LOC108245811	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
	LOC108241259	Notum, palmitoleoyl-protein carboxylesterase a. (504 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	LOC108248763	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
	ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (955 aa)
	ror2	Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (937 aa)
	LOC108231486	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
	LOC108235105	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (401 aa)
	LOC108228356	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa)
	wnt7a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	LOC108238006	Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (555 aa)
	bambi	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (255 aa)
	ryk	Receptor like tyrosine kinase. (628 aa)
	ENSKMAP00000021756	Frizzled class receptor 1. (233 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	LOC108242552	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	LOC108231910	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (450 aa)
	LOC108246125	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	Wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
	notum	Uncharacterized protein. (436 aa)
	FZD3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (734 aa)
	LOC108235134	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	Fzd2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (547 aa)
	Fzd10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	LOC108235165	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
	sfrp5	Secreted frizzled-related protein 5. (307 aa)
	LOC108236300	Notum pectinacetylesterase 2. (523 aa)
	wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (433 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000000736	ENSKMAP00000021756	ENSKMAP00000000736	ENSKMAP00000021756	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 1.	0.768
ENSKMAP00000000736	FZD3	ENSKMAP00000000736	ENSKMAP00000026222	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.799
ENSKMAP00000000736	FZD7	ENSKMAP00000000736	ENSKMAP00000001744	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	0.785
ENSKMAP00000000736	Fzd10	ENSKMAP00000000736	ENSKMAP00000027488	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	0.804
ENSKMAP00000000736	Fzd2	ENSKMAP00000000736	ENSKMAP00000026394	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.808
ENSKMAP00000000736	LOC108228356	ENSKMAP00000000736	ENSKMAP00000019246	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.743
ENSKMAP00000000736	LOC108231910	ENSKMAP00000000736	ENSKMAP00000024040	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	0.799
ENSKMAP00000000736	LOC108235105	ENSKMAP00000000736	ENSKMAP00000019094	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.418
ENSKMAP00000000736	LOC108235134	ENSKMAP00000000736	ENSKMAP00000026275	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.418
ENSKMAP00000000736	LOC108236300	ENSKMAP00000000736	ENSKMAP00000028999	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Notum pectinacetylesterase 2.	0.715
ENSKMAP00000000736	LOC108241259	ENSKMAP00000000736	ENSKMAP00000014023	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Notum, palmitoleoyl-protein carboxylesterase a.	0.715
ENSKMAP00000000736	LOC108242552	ENSKMAP00000000736	ENSKMAP00000023653	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.471
ENSKMAP00000000736	LOC108248723	ENSKMAP00000000736	ENSKMAP00000010993	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein 1a.	0.789
ENSKMAP00000000736	LOC108248763	ENSKMAP00000000736	ENSKMAP00000014283	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family.	0.797
ENSKMAP00000000736	Wnt16	ENSKMAP00000000736	ENSKMAP00000025377	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.476
ENSKMAP00000000736	fzd3	ENSKMAP00000000736	ENSKMAP00000005450	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family.	0.799
ENSKMAP00000000736	fzd4	ENSKMAP00000000736	ENSKMAP00000010577	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.833
ENSKMAP00000000736	fzd6	ENSKMAP00000000736	ENSKMAP00000003200	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.799
ENSKMAP00000000736	fzd9	ENSKMAP00000000736	ENSKMAP00000003324	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family.	0.804
ENSKMAP00000000736	notum	ENSKMAP00000000736	ENSKMAP00000025818	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.715