(98 nodes) Mixed, incl. Nuclear Receptor transcription pathway, and Protein arginine N-methyltransferase network (Kryptolebias marmoratus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSKMAP00000000486	Histone domain-containing protein. (138 aa)
	ppara	Peroxisome proliferator-activated receptor alpha a. (471 aa)
	LOC108249639	Nuclear receptor subfamily 1, group D, member 2b. (576 aa)
	LOC108239853	Vitamin D receptor b. (425 aa)
	LOC108230807	Uncharacterized protein. (453 aa)
	LOC108238745	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	LOC108241049	Cellular retinoic acid binding protein 2, a; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (142 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
	ESRRB	Estrogen-related receptor beta. (447 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (464 aa)
	ppargc1b	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (904 aa)
	pgr	Progesterone receptor. (659 aa)
	LOC108238308	Transducin (beta)-like 1 X-linked receptor 1b. (512 aa)
	nr3c2	Nuclear receptor subfamily 3, group C, member 2. (994 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (486 aa)
	LOC108233113	Nuclear receptor subfamily 1, group H, member 5. (466 aa)
	znf277	Zinc finger protein 277. (439 aa)
	LOC108247437	Androgen receptor. (742 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (940 aa)
	ntmt1	N-terminal Xaa-Pro-Lys N-methyltransferase 1. (222 aa)
	usf1	Upstream transcription factor 1. (299 aa)
	LOC108240578	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (745 aa)
	LOC108250440	E1A binding protein p300 a. (2399 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	LOC108233105	Uncharacterized protein. (420 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (509 aa)
	ncoa2	Nuclear receptor coactivator. (1424 aa)
	LOC108231300	Peptidylprolyl isomerase. (448 aa)
	LOC108248710	Fork-head domain-containing protein. (411 aa)
	nr5a2	Uncharacterized protein. (524 aa)
	LOC108251066	Cellular retinoic acid binding protein 1a; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
	LOC108251072	Uncharacterized protein. (557 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (792 aa)
	PPARG	Peroxisome proliferator activated receptor gamma. (533 aa)
	LOC108248182	Uncharacterized protein. (515 aa)
	ctbp1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (443 aa)
	Kmt2e	Lysine (K)-specific methyltransferase 2E. (430 aa)
	recql	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (820 aa)
	esrra	Estrogen-related receptor alpha. (433 aa)
	LOC108238271	Cellular retinoic acid binding protein 2, b; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (173 aa)
	sp1	Sp1 transcription factor. (702 aa)
	ENSKMAP00000016395	Upstream transcription factor 2, c-fos interacting. (310 aa)
	ncor1	Nuclear receptor corepressor 1. (2321 aa)
	LOC108232068	Uncharacterized protein. (1520 aa)
	LOC108246458	Uncharacterized protein. (459 aa)
	LOC108235188	Sp3b transcription factor. (661 aa)
	pdcd2l	Programmed cell death 2-like. (381 aa)
	CTBP2	C-terminal binding protein 2. (877 aa)
	hnf4a	Hepatocyte nuclear factor 4, alpha. (454 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	LOC108235477	Uncharacterized protein. (117 aa)
	LOC108242428	Uncharacterized protein. (435 aa)
	LOC108251202	Nuclear receptor subfamily 1, group d, member 1. (604 aa)
	LOC108246013	Nuclear receptor subfamily 2, group F, member 5. (406 aa)
	gata3	GATA binding protein 3. (441 aa)
	LOC108251251	Forkhead box A3. (457 aa)
	nrf1	Nuclear respiratory factor 1. (520 aa)
	LOC108243630	Uncharacterized protein. (317 aa)
	LOC108244845	Nuclear receptor subfamily 2, group F, member 6a. (408 aa)
	cir1	Corepressor interacting with RBPJ, 1. (448 aa)
	prmt7	Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (685 aa)
	LOC108243131	Hepatocyte nuclear factor 4, gamma. (455 aa)
	LOC108235086	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (325 aa)
	LOC108241994	Retinoid x receptor, beta b. (427 aa)
	LOC108237972	Uncharacterized protein. (666 aa)
	rxra	Retinoid X receptor, alpha a. (496 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (468 aa)
	ncoa1	Nuclear receptor coactivator 1. (1473 aa)
	LOC108235710	Retinoic acid receptor, gamma b. (504 aa)
	LOC108235787	Nuclear receptor subfamily 1, group D, member 4b. (559 aa)
	clns1a	Chloride channel, nucleotide-sensitive, 1A. (246 aa)
	Prmt6	Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (357 aa)
	ENSKMAP00000023638	Uncharacterized protein. (262 aa)
	rora	RAR-related orphan receptor A, paralog a. (468 aa)
	LOC108239707	Transducin beta like 1 X-linked. (513 aa)
	nrip1	Nuclear receptor interacting protein 1b. (1092 aa)
	esrrg	Estrogen-related receptor gamma a. (521 aa)
	hnf1b	HNF1 homeobox Ba. (568 aa)
	tgs1	Uncharacterized protein. (801 aa)
	LOC108249620	Estrogen receptor 2b. (664 aa)
	usf2	BHLH domain-containing protein. (318 aa)
	LOC108243298	Nuclear receptor subfamily 1, group D, member 2a. (553 aa)
	ncor2	Nuclear receptor corepressor 2. (1795 aa)
	LOC108238600	Uncharacterized protein. (265 aa)
	prmt3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (529 aa)
	prmt2	Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (387 aa)
	prmt5	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (631 aa)
	carm1	Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (581 aa)
	LOC108238584	Kruppel-like factor 17. (441 aa)
	nr0b2	Nuclear receptor subfamily 0, group B, member 2a. (258 aa)
	LOC108235153	Nuclear receptor subfamily 1, group D, member 4a. (576 aa)
	WDR77	WD repeat domain 77. (337 aa)
	RXRB	Retinoid X receptor beta. (469 aa)
	LOC108243856	Nuclear receptor coactivator. (1504 aa)
	LOC108244406	Nuclear receptor coactivator 3. (1518 aa)
	nr1i2	Nuclear receptor subfamily 1, group I, member 2. (444 aa)
	LOC108237473	Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (362 aa)
	LOC108233438	Estrogen receptor 2a. (559 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTBP2	HDAC1	ENSKMAP00000018054	ENSKMAP00000018387	C-terminal binding protein 2.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.906
CTBP2	HDAC3	ENSKMAP00000018054	ENSKMAP00000008945	C-terminal binding protein 2.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.532
CTBP2	LOC108238745	ENSKMAP00000018054	ENSKMAP00000001750	C-terminal binding protein 2.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.906
CTBP2	nrip1	ENSKMAP00000018054	ENSKMAP00000024707	C-terminal binding protein 2.	Nuclear receptor interacting protein 1b.	0.459
ENSKMAP00000000486	carm1	ENSKMAP00000000486	ENSKMAP00000027817	Histone domain-containing protein.	Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.478
ENSKMAP00000016395	LOC108232068	ENSKMAP00000016395	ENSKMAP00000016635	Upstream transcription factor 2, c-fos interacting.	Uncharacterized protein.	0.444
ENSKMAP00000016395	LOC108243856	ENSKMAP00000016395	ENSKMAP00000028801	Upstream transcription factor 2, c-fos interacting.	Nuclear receptor coactivator.	0.444
ENSKMAP00000016395	LOC108244406	ENSKMAP00000016395	ENSKMAP00000028949	Upstream transcription factor 2, c-fos interacting.	Nuclear receptor coactivator 3.	0.444
ENSKMAP00000016395	LOC108250440	ENSKMAP00000016395	ENSKMAP00000008734	Upstream transcription factor 2, c-fos interacting.	E1A binding protein p300 a.	0.575
ENSKMAP00000016395	ncoa1	ENSKMAP00000016395	ENSKMAP00000022890	Upstream transcription factor 2, c-fos interacting.	Nuclear receptor coactivator 1.	0.444
ENSKMAP00000016395	ncoa2	ENSKMAP00000016395	ENSKMAP00000009784	Upstream transcription factor 2, c-fos interacting.	Nuclear receptor coactivator.	0.444
ENSKMAP00000016395	sp1	ENSKMAP00000016395	ENSKMAP00000016217	Upstream transcription factor 2, c-fos interacting.	Sp1 transcription factor.	0.644
ENSKMAP00000016395	usf1	ENSKMAP00000016395	ENSKMAP00000008252	Upstream transcription factor 2, c-fos interacting.	Upstream transcription factor 1.	0.920
ENSKMAP00000023638	HDAC1	ENSKMAP00000023638	ENSKMAP00000018387	Uncharacterized protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.726
ENSKMAP00000023638	HDAC3	ENSKMAP00000023638	ENSKMAP00000008945	Uncharacterized protein.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.726
ENSKMAP00000023638	Kmt2e	ENSKMAP00000023638	ENSKMAP00000014788	Uncharacterized protein.	Lysine (K)-specific methyltransferase 2E.	0.402
ENSKMAP00000023638	LOC108235787	ENSKMAP00000023638	ENSKMAP00000023191	Uncharacterized protein.	Nuclear receptor subfamily 1, group D, member 4b.	0.766
ENSKMAP00000023638	LOC108238308	ENSKMAP00000023638	ENSKMAP00000005490	Uncharacterized protein.	Transducin (beta)-like 1 X-linked receptor 1b.	0.828
ENSKMAP00000023638	LOC108238745	ENSKMAP00000023638	ENSKMAP00000001750	Uncharacterized protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.726
ENSKMAP00000023638	LOC108239707	ENSKMAP00000023638	ENSKMAP00000024263	Uncharacterized protein.	Transducin beta like 1 X-linked.	0.828