STRINGSTRING
RPA1 RPA1 xrcc3 xrcc3 top3b top3b mus81 mus81 rpa1 rpa1 ENSKMAP00000009313 ENSKMAP00000009313 LOC108248126 LOC108248126 brca2 brca2 recql5 recql5 fancm fancm recql4 recql4 rad52 rad52 rad51 rad51 rad51d rad51d rpa2 rpa2 rad51c rad51c rpa3 rpa3 top3a top3a xrcc2 xrcc2 blm blm exd2 exd2 rmi2 rmi2 DNA2 DNA2 rmi1 rmi1 fbh1 fbh1 tdrd3 tdrd3 dmc1 dmc1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (343 aa)
top3bDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa)
mus81MUS81 structure-specific endonuclease subunit. (556 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
ENSKMAP00000009313Methionine sulfoxide reductase B1b. (467 aa)
LOC108248126RPA_C domain-containing protein. (199 aa)
brca2BRCA2 DNA repair associated. (2641 aa)
recql5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (996 aa)
fancmHelicase C-terminal domain-containing protein. (1616 aa)
recql4RecQ helicase-like 4. (1281 aa)
rad52RAD52 homolog, DNA repair protein. (382 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (334 aa)
rad51dRAD51 paralog D. (333 aa)
rpa2RPA_C domain-containing protein. (274 aa)
rad51cRAD51 paralog C. (342 aa)
rpa3Replication protein A 14kDa subunit. (122 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1023 aa)
xrcc2RECA_2 domain-containing protein. (357 aa)
blmBLM RecQ like helicase. (1384 aa)
exd2Exonuclease 3'-5' domain containing 2. (639 aa)
rmi2RecQ mediated genome instability 2. (145 aa)
DNA2DNA replication helicase/nuclease 2. (1388 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (699 aa)
fbh1F-box DNA helicase 1. (1108 aa)
tdrd3Tudor domain containing 3. (787 aa)
dmc1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (334 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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