7 items (Kryptolebias marmoratus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

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gene neighborhood

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protein homology

Your Input:
	hltf	Helicase-like transcription factor. (930 aa)
	ube2n	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	ube2v2	Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
	LOC108235081	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	ENSKMAP00000019873	UBIQUITIN_CONJUGAT_2 domain-containing protein. (144 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (515 aa)
	rad18	RAD18 E3 ubiquitin protein ligase. (490 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000019873	LOC108235081	ENSKMAP00000019873	ENSKMAP00000018377	UBIQUITIN_CONJUGAT_2 domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.939
ENSKMAP00000019873	hltf	ENSKMAP00000019873	ENSKMAP00000005290	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Helicase-like transcription factor.	0.918
ENSKMAP00000019873	rad18	ENSKMAP00000019873	ENSKMAP00000027942	UBIQUITIN_CONJUGAT_2 domain-containing protein.	RAD18 E3 ubiquitin protein ligase.	0.799
ENSKMAP00000019873	rnf8	ENSKMAP00000019873	ENSKMAP00000024948	UBIQUITIN_CONJUGAT_2 domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.822
ENSKMAP00000019873	ube2n	ENSKMAP00000019873	ENSKMAP00000006002	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.939
LOC108235081	ENSKMAP00000019873	ENSKMAP00000018377	ENSKMAP00000019873	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.939
LOC108235081	hltf	ENSKMAP00000018377	ENSKMAP00000005290	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Helicase-like transcription factor.	0.936
LOC108235081	rad18	ENSKMAP00000018377	ENSKMAP00000027942	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	RAD18 E3 ubiquitin protein ligase.	0.859
LOC108235081	rnf8	ENSKMAP00000018377	ENSKMAP00000024948	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.945
LOC108235081	ube2n	ENSKMAP00000018377	ENSKMAP00000006002	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.900
LOC108235081	ube2v2	ENSKMAP00000018377	ENSKMAP00000006860	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2 variant 2.	0.974
hltf	ENSKMAP00000019873	ENSKMAP00000005290	ENSKMAP00000019873	Helicase-like transcription factor.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.918
hltf	LOC108235081	ENSKMAP00000005290	ENSKMAP00000018377	Helicase-like transcription factor.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.936
hltf	rad18	ENSKMAP00000005290	ENSKMAP00000027942	Helicase-like transcription factor.	RAD18 E3 ubiquitin protein ligase.	0.977
hltf	ube2n	ENSKMAP00000005290	ENSKMAP00000006002	Helicase-like transcription factor.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.936
hltf	ube2v2	ENSKMAP00000005290	ENSKMAP00000006860	Helicase-like transcription factor.	Ubiquitin-conjugating enzyme E2 variant 2.	0.940
rad18	ENSKMAP00000019873	ENSKMAP00000027942	ENSKMAP00000019873	RAD18 E3 ubiquitin protein ligase.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.799
rad18	LOC108235081	ENSKMAP00000027942	ENSKMAP00000018377	RAD18 E3 ubiquitin protein ligase.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.859
rad18	hltf	ENSKMAP00000027942	ENSKMAP00000005290	RAD18 E3 ubiquitin protein ligase.	Helicase-like transcription factor.	0.977
rad18	rnf8	ENSKMAP00000027942	ENSKMAP00000024948	RAD18 E3 ubiquitin protein ligase.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.570