STRINGSTRING
LOC108244378 LOC108244378 daxx daxx htt htt nop53 nop53 prmt5 prmt5 chd8 chd8 LOC108241482 LOC108241482 LOC108247761 LOC108247761 LOC108234029 LOC108234029 ENSKMAP00000024388 ENSKMAP00000024388 usp7 usp7 blm blm ep300 ep300 bcl2l12 bcl2l12 tp63 tp63 LOC108241331 LOC108241331 LOC108247643 LOC108247643 mdm4 mdm4 tp53rk tp53rk tp73 tp73 LOC108230475 LOC108230475 kdm1a kdm1a ENSKMAP00000012711 ENSKMAP00000012711 ehmt1 ehmt1 sirt1 sirt1 rchy1 rchy1 LOC108232543 LOC108232543 rfwd3 rfwd3 tp53bp1 tp53bp1 usp10 usp10 LOC108249214 LOC108249214 LOC108250440 LOC108250440 stk11 stk11 psme3 psme3 rffl rffl cdk5 cdk5 LOC108228750 LOC108228750 taf3 taf3 mul1 mul1 LOC108236517 LOC108236517 ehmt2 ehmt2 brd7 brd7 msx1 msx1 mdm2 mdm2 mapkapk5 mapkapk5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108244378GATA binding protein 1a. (426 aa)
daxxDeath-domain associated protein. (756 aa)
httHuntingtin. (3092 aa)
nop53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (443 aa)
prmt5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (631 aa)
chd8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2616 aa)
LOC108241482CREB binding protein a. (2490 aa)
LOC108247761Uncharacterized protein. (182 aa)
LOC108234029Muscle segment homeobox 3. (243 aa)
ENSKMAP00000024388TROVE domain-containing protein. (983 aa)
usp7Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1102 aa)
blmBLM RecQ like helicase. (1384 aa)
ep300E1A binding protein p300 b. (2785 aa)
bcl2l12Uncharacterized protein. (366 aa)
tp63Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (665 aa)
LOC108241331Bromodomain containing 4. (1516 aa)
LOC108247643CREB binding protein b. (2428 aa)
mdm4MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (490 aa)
tp53rkTP53 regulating kinase. (229 aa)
tp73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (719 aa)
LOC108230475Uncharacterized protein. (1443 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (837 aa)
ENSKMAP00000012711SET domain-containing protein. (135 aa)
ehmt1Euchromatic histone-lysine N-methyltransferase 1b. (1271 aa)
sirt1Sirtuin 1. (693 aa)
rchy1Ring finger and CHY zinc finger domain containing 1. (267 aa)
LOC108232543Ring finger protein 34b. (408 aa)
rfwd3Ring finger and WD repeat domain 3. (712 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1702 aa)
usp10Ubiquitin carboxyl-terminal hydrolase. (874 aa)
LOC108249214CDKN2A interacting protein. (319 aa)
LOC108250440E1A binding protein p300 a. (2399 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
psme3Proteasome activator subunit 3. (256 aa)
rfflRing finger and FYVE-like domain containing E3 ubiquitin protein ligase. (410 aa)
cdk5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
LOC108228750Uncharacterized protein. (332 aa)
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto. (982 aa)
mul1Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
LOC108236517Ring finger protein 34a. (474 aa)
ehmt2Euchromatic histone-lysine N-methyltransferase 2. (1175 aa)
brd7Bromodomain containing 7. (620 aa)
msx1Muscle segment homeobox 1a. (289 aa)
mdm2MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family. (448 aa)
mapkapk5MAPK activated protein kinase 5. (471 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
Server load: low (30%) [HD]