STRINGSTRING
LOC108228507 LOC108228507 dnmt1 dnmt1 pold3 pold3 timeless timeless xrcc2 xrcc2 pola1 pola1 rpa3 rpa3 rad51c rad51c tipin tipin ENSKMAP00000018800 ENSKMAP00000018800 zranb3 zranb3 rad51d rad51d prim1 prim1 smarcal1 smarcal1 rfc4 rfc4 prpf19 prpf19 pold1 pold1 polh polh tex264 tex264 wdhd1 wdhd1 rad18 rad18 dmap1 dmap1 chek1 chek1 mcm10 mcm10 mre11 mre11 tonsl tonsl rfc2 rfc2 ENSKMAP00000010500 ENSKMAP00000010500 pold4 pold4 tp53bp1 tp53bp1 uhrf1 uhrf1 hmces hmces TEX264 TEX264 rfc3 rfc3 rpa1 rpa1 radx radx pold2 pold2 mms22l mms22l xrcc3 xrcc3 pif1 pif1 rfc5 rfc5 primpol primpol RPA1 RPA1 rfc1 rfc1 DONSON DONSON prim2 prim2 pola2 pola2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108228507ATP-dependent DNA helicase; Belongs to the helicase family. (1236 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1507 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (440 aa)
timelessTimeless circadian clock. (1247 aa)
xrcc2RECA_2 domain-containing protein. (357 aa)
pola1DNA polymerase. (1476 aa)
rpa3Replication protein A 14kDa subunit. (122 aa)
rad51cRAD51 paralog C. (342 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (270 aa)
ENSKMAP00000018800Uncharacterized protein. (523 aa)
zranb3Zinc finger, RAN-binding domain containing 3. (984 aa)
rad51dRAD51 paralog D. (333 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (427 aa)
smarcal1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (868 aa)
rfc4Replication factor C (activator 1) 4. (388 aa)
prpf19Pre-mRNA processing factor 19. (505 aa)
pold1DNA polymerase. (1105 aa)
polhPolymerase (DNA directed), eta. (738 aa)
tex264Testis expressed 264, ER-phagy receptor a. (339 aa)
wdhd1WD repeat and HMG-box DNA binding protein 1. (954 aa)
rad18RAD18 E3 ubiquitin protein ligase. (490 aa)
dmap1DNA methyltransferase 1 associated protein 1. (483 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (455 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (848 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (696 aa)
tonslTonsoku-like, DNA repair protein. (1413 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
ENSKMAP00000010500Uncharacterized protein. (850 aa)
pold4Uncharacterized protein. (110 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1702 aa)
uhrf1Ubiquitin-like with PHD and ring finger domains 1. (777 aa)
hmcesAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (365 aa)
TEX264Testis expressed 264, ER-phagy receptor. (306 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
radxRPA1 related single stranded DNA binding protein. (771 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
mms22lMMS22-like, DNA repair protein. (1212 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (343 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (626 aa)
rfc5Replication factor C (activator 1) 5. (339 aa)
primpolPrimase and polymerase (DNA-directed). (492 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
rfc1Replication factor C subunit 1. (1180 aa)
DONSONDownstream neighbor of SON. (485 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (516 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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