STRINGSTRING
lig4 lig4 ercc6 ercc6 ercc1 ercc1 xpa xpa poll poll gtf2h1 gtf2h1 ENSKMAP00000028503 ENSKMAP00000028503 ercc2 ercc2 ercc3 ercc3 fan1 fan1 ercc4 ercc4 LOC108232507 LOC108232507 ercc5 ercc5 ddb2 ddb2 slx4 slx4 gtf2h3 gtf2h3 nthl1 nthl1 usp7 usp7 pold3 pold3 xab2 xab2 ogg1 ogg1 LOC108238001 LOC108238001 ENSKMAP00000020750 ENSKMAP00000020750 Pole Pole bivm bivm RAD23B RAD23B rpa3 rpa3 ercc8 ercc8 ENSKMAP00000018989 ENSKMAP00000018989 polk polk hus1 hus1 pold1 pold1 rad23a rad23a gtf2h5 gtf2h5 sirt1 sirt1 LOC108236604 LOC108236604 brca2 brca2 uvssa uvssa LOC108240516 LOC108240516 mnat1 mnat1 rpa1 rpa1 xpc xpc polr2i polr2i gtf2h4 gtf2h4 RPA1 RPA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lig4DNA ligase. (922 aa)
ercc6Excision repair cross-complementation group 6. (1442 aa)
ercc1Excision repair cross-complementation group 1. (352 aa)
xpaXeroderma pigmentosum, complementation group A. (275 aa)
pollPolymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (571 aa)
gtf2h1General transcription factor IIH, polypeptide 1. (409 aa)
ENSKMAP00000028503PH_TFIIH domain-containing protein. (131 aa)
ercc2Excision repair cross-complementation group 2. (760 aa)
ercc3Excision repair cross-complementation group 3. (783 aa)
fan1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (969 aa)
ercc4Excision repair cross-complementation group 4. (899 aa)
LOC108232507General transcription factor IIH subunit. (392 aa)
ercc5Excision repair cross-complementation group 5. (1028 aa)
ddb2Damage-specific DNA binding protein 2. (497 aa)
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1695 aa)
gtf2h3General transcription factor IIH, polypeptide 3. (299 aa)
nthl1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (323 aa)
usp7Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1102 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (440 aa)
xab2XPA binding protein 2. (849 aa)
ogg18-oxoguanine DNA glycosylase. (410 aa)
LOC108238001High mobility group nucleosome binding domain 6. (94 aa)
ENSKMAP00000020750DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (314 aa)
PoleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (298 aa)
bivmBasic, immunoglobulin-like variable motif containing. (481 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (396 aa)
rpa3Replication protein A 14kDa subunit. (122 aa)
ercc8Excision repair cross-complementation group 8. (401 aa)
ENSKMAP00000018989Uncharacterized protein. (152 aa)
polkPolymerase (DNA directed) kappa. (401 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
pold1DNA polymerase. (1105 aa)
rad23aRAD23 homolog A, nucleotide excision repair protein a. (365 aa)
gtf2h5General transcription factor IIH, polypeptide 5. (71 aa)
sirt1Sirtuin 1. (693 aa)
LOC108236604Centrin 4. (173 aa)
brca2BRCA2 DNA repair associated. (2641 aa)
uvssaUV-stimulated scaffold protein A. (762 aa)
LOC108240516Centrin, EF-hand protein, 2. (177 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
xpcXeroderma pigmentosum, complementation group C. (935 aa)
polr2iDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
gtf2h4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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