54 items (Kryptolebias marmoratus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	ski	V-ski avian sarcoma viral oncogene homolog a. (719 aa)
	ENSKMAP00000001053	Uncharacterized protein. (109 aa)
	Topors	Uncharacterized protein. (109 aa)
	wdfy3	WD repeat and FYVE domain containing 3. (3521 aa)
	sumo1	Small ubiquitin-related modifier. (105 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2516 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (940 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
	LOC108247429	Uncharacterized protein. (1905 aa)
	LOC108248076	Checkpoint kinase 2. (534 aa)
	tdg	Thymine DNA glycosylase, tandem duplicate 1. (444 aa)
	LOC108245718	Thymine DNA glycosylase, tandem duplicate 2. (387 aa)
	atrx	ATRX chromatin remodeler. (2228 aa)
	tdp2	Tyrosyl-DNA phosphodiesterase 2b. (360 aa)
	smc5	Structural maintenance of chromosomes 5. (1078 aa)
	LOC108240530	Germ cell nuclear acidic peptidase. (579 aa)
	rfwd3	Ring finger and WD repeat domain 3. (712 aa)
	rnf111	Ring finger protein 111. (1023 aa)
	ankrd1	Ankyrin repeat domain 1a (cardiac muscle). (314 aa)
	sirt1	Sirtuin 1. (693 aa)
	chfr	Checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase. (691 aa)
	trim8	Tripartite motif containing 8b. (566 aa)
	casp8ap2	Uncharacterized protein. (1806 aa)
	ENSKMAP00000014889	Si:dkey-119f1.1. (1095 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (334 aa)
	rb1	Retinoblastoma 1. (915 aa)
	rpain	RPA interacting protein. (227 aa)
	top3a	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1023 aa)
	LOC108251266	Endo/exonuclease/phosphatase domain-containing protein. (311 aa)
	LOC108228415	RING-type domain-containing protein. (844 aa)
	smc6	Structural maintenance of chromosomes 6. (1092 aa)
	blm	BLM RecQ like helicase. (1384 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1510 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1102 aa)
	Ciita	NACHT domain-containing protein. (925 aa)
	rnf4	RING-type domain-containing protein. (198 aa)
	sqstm1	Sequestosome 1. (430 aa)
	LOC108246670	CW-type domain-containing protein. (631 aa)
	ENSKMAP00000024756	Uncharacterized protein. (257 aa)
	ENSKMAP00000024903	Uncharacterized protein. (286 aa)
	ENSKMAP00000024917	Uncharacterized protein. (183 aa)
	ENSKMAP00000024942	Uncharacterized protein. (191 aa)
	tp53inp2	Uncharacterized protein. (302 aa)
	mlip	Uncharacterized protein. (827 aa)
	n4bp1	Nedd4 binding protein 1. (734 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (284 aa)
	LOC108233935	RING-type domain-containing protein. (565 aa)
	LOC108251390	PAT1 homolog 1, processing body mRNA decay factor. (825 aa)
	Nfe2	Nuclear factor, erythroid 2. (432 aa)
	nsmce2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (228 aa)
	LOC108247727	PAT1 homolog 2. (713 aa)
	daxx	Death-domain associated protein. (756 aa)
	klhl20	Kelch-like family member 20. (604 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000001053	ENSKMAP00000014889	ENSKMAP00000001053	ENSKMAP00000014889	Uncharacterized protein.	Si:dkey-119f1.1.	0.560
ENSKMAP00000001053	LOC108248076	ENSKMAP00000001053	ENSKMAP00000007793	Uncharacterized protein.	Checkpoint kinase 2.	0.995
ENSKMAP00000001053	RPA1	ENSKMAP00000001053	ENSKMAP00000000242	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.953
ENSKMAP00000001053	blm	ENSKMAP00000001053	ENSKMAP00000022385	Uncharacterized protein.	BLM RecQ like helicase.	0.961
ENSKMAP00000001053	mtor	ENSKMAP00000001053	ENSKMAP00000007071	Uncharacterized protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.455
ENSKMAP00000001053	nsmce2	ENSKMAP00000001053	ENSKMAP00000028416	Uncharacterized protein.	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	0.649
ENSKMAP00000001053	rad51	ENSKMAP00000001053	ENSKMAP00000017025	Uncharacterized protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.891
ENSKMAP00000001053	rfwd3	ENSKMAP00000001053	ENSKMAP00000009816	Uncharacterized protein.	Ring finger and WD repeat domain 3.	0.491
ENSKMAP00000001053	rpa1	ENSKMAP00000001053	ENSKMAP00000007505	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.953
ENSKMAP00000001053	smc5	ENSKMAP00000001053	ENSKMAP00000009554	Uncharacterized protein.	Structural maintenance of chromosomes 5.	0.755
ENSKMAP00000001053	smc6	ENSKMAP00000001053	ENSKMAP00000021206	Uncharacterized protein.	Structural maintenance of chromosomes 6.	0.560
ENSKMAP00000001053	sqstm1	ENSKMAP00000001053	ENSKMAP00000024409	Uncharacterized protein.	Sequestosome 1.	0.906
ENSKMAP00000001053	top3a	ENSKMAP00000001053	ENSKMAP00000020771	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.811
ENSKMAP00000001053	topbp1	ENSKMAP00000001053	ENSKMAP00000022967	Uncharacterized protein.	DNA topoisomerase II binding protein 1.	0.980
ENSKMAP00000014889	ENSKMAP00000001053	ENSKMAP00000014889	ENSKMAP00000001053	Si:dkey-119f1.1.	Uncharacterized protein.	0.560
ENSKMAP00000014889	LOC108248076	ENSKMAP00000014889	ENSKMAP00000007793	Si:dkey-119f1.1.	Checkpoint kinase 2.	0.448
ENSKMAP00000014889	blm	ENSKMAP00000014889	ENSKMAP00000022385	Si:dkey-119f1.1.	BLM RecQ like helicase.	0.692
ENSKMAP00000014889	nsmce2	ENSKMAP00000014889	ENSKMAP00000028416	Si:dkey-119f1.1.	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	0.970
ENSKMAP00000014889	rad51	ENSKMAP00000014889	ENSKMAP00000017025	Si:dkey-119f1.1.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.725
ENSKMAP00000014889	smc5	ENSKMAP00000014889	ENSKMAP00000009554	Si:dkey-119f1.1.	Structural maintenance of chromosomes 5.	0.977