39 items (Kryptolebias marmoratus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	derl1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (258 aa)
	LOC108240827	Bone morphogenetic protein 16. (416 aa)
	LOC108235698	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (166 aa)
	LOC108244942	Tribbles pseudokinase 3. (351 aa)
	pkd1	Polycystic kidney disease 1a. (4448 aa)
	LOC108249571	Si:dkey-3h3.3. (421 aa)
	bambi	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (255 aa)
	poldip2	Polymerase (DNA-directed), delta interacting protein 2. (375 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2550 aa)
	nvl	Nuclear VCP like. (821 aa)
	ENSKMAP00000016720	Apolipoprotein Eb. (264 aa)
	LOC108244765	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	LOC108248208	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	spon1	Spondin 1a. (808 aa)
	sppl3	Signal peptide peptidase 3. (383 aa)
	rapgef2	Rap guanine nucleotide exchange factor (GEF) 2. (1443 aa)
	ENSKMAP00000023965	Uncharacterized protein. (240 aa)
	abl1	Tyrosine-protein kinase. (1121 aa)
	LOC108246043	Vitronectin a. (525 aa)
	ide	Insulin-degrading enzyme. (977 aa)
	ep300	E1A binding protein p300 b. (2785 aa)
	Cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (111 aa)
	Prkn	RBR-type E3 ubiquitin transferase. (174 aa)
	cthrc1	Collagen triple helix repeat containing 1b. (277 aa)
	ENSKMAP00000002093	Polycystic kidney disease 1b. (2655 aa)
	LOC108250392	Apolipoprotein Ea. (251 aa)
	LOC108244568	RING-type domain-containing protein. (223 aa)
	cdk5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (581 aa)
	abl2	Tyrosine-protein kinase. (1203 aa)
	LOC108245271	Beta-1,3-N-acetylglucosaminyltransferase. (349 aa)
	LOC108249275	Sperm associated antigen 8. (186 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	LOC108243468	Uncharacterized protein. (775 aa)
	LOC108238902	Vitronectin b. (439 aa)
	LOC108250440	E1A binding protein p300 a. (2399 aa)
	men1	Multiple endocrine neoplasia I. (628 aa)
	LOC108244555	Zgc:66440. (369 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cldn5	LOC108244765	ENSKMAP00000004361	ENSKMAP00000016510	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.654
Cldn5	LOC108248208	ENSKMAP00000004361	ENSKMAP00000014825	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.487
ENSKMAP00000016720	LOC108238902	ENSKMAP00000016720	ENSKMAP00000009448	Apolipoprotein Eb.	Vitronectin b.	0.552
ENSKMAP00000016720	LOC108246043	ENSKMAP00000016720	ENSKMAP00000021852	Apolipoprotein Eb.	Vitronectin a.	0.552
ENSKMAP00000016720	LOC108248208	ENSKMAP00000016720	ENSKMAP00000014825	Apolipoprotein Eb.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.408
LOC108238902	ENSKMAP00000016720	ENSKMAP00000009448	ENSKMAP00000016720	Vitronectin b.	Apolipoprotein Eb.	0.552
LOC108238902	LOC108246043	ENSKMAP00000009448	ENSKMAP00000021852	Vitronectin b.	Vitronectin a.	0.906
LOC108238902	LOC108250392	ENSKMAP00000009448	ENSKMAP00000007405	Vitronectin b.	Apolipoprotein Ea.	0.448
LOC108244765	Cldn5	ENSKMAP00000016510	ENSKMAP00000004361	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.654
LOC108244765	LOC108248208	ENSKMAP00000016510	ENSKMAP00000014825	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.487
LOC108246043	ENSKMAP00000016720	ENSKMAP00000021852	ENSKMAP00000016720	Vitronectin a.	Apolipoprotein Eb.	0.552
LOC108246043	LOC108238902	ENSKMAP00000021852	ENSKMAP00000009448	Vitronectin a.	Vitronectin b.	0.906
LOC108246043	LOC108250392	ENSKMAP00000021852	ENSKMAP00000007405	Vitronectin a.	Apolipoprotein Ea.	0.448
LOC108248208	Cldn5	ENSKMAP00000014825	ENSKMAP00000004361	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.487
LOC108248208	ENSKMAP00000016720	ENSKMAP00000014825	ENSKMAP00000016720	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Apolipoprotein Eb.	0.408
LOC108248208	LOC108244765	ENSKMAP00000014825	ENSKMAP00000016510	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.487
LOC108250392	LOC108238902	ENSKMAP00000007405	ENSKMAP00000009448	Apolipoprotein Ea.	Vitronectin b.	0.448
LOC108250392	LOC108246043	ENSKMAP00000007405	ENSKMAP00000021852	Apolipoprotein Ea.	Vitronectin a.	0.448
Prkn	cdk5	ENSKMAP00000003145	ENSKMAP00000006034	RBR-type E3 ubiquitin transferase.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.459
Prkn	lrrk2	ENSKMAP00000003145	ENSKMAP00000019647	RBR-type E3 ubiquitin transferase.	Leucine-rich repeat kinase 2.	0.654