(17 nodes) Regulation of intracellular estrogen receptor signaling pathway network (Kryptolebias marmoratus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	carm1	Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (581 aa)
	LOC108233570	Zinc finger protein 366. (757 aa)
	cnot2	CCR4-NOT transcription complex, subunit 2. (522 aa)
	LOC108229396	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (615 aa)
	LOC108247437	Androgen receptor. (742 aa)
	LOC108228859	VPS11 core subunit of CORVET and HOPS complexes. (489 aa)
	cnot1	CCR4-NOT transcription complex, subunit 1. (2381 aa)
	LOC108249808	NOT2_3_5 domain-containing protein. (557 aa)
	LOC108244165	CCR4-NOT transcription complex subunit 9. (301 aa)
	ENSKMAP00000021859	VPS11 core subunit of CORVET and HOPS complexes. (286 aa)
	LOC108237972	Uncharacterized protein. (666 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1802 aa)
	cnot9	CCR4-NOT transcription complex subunit 9. (299 aa)
	kank2	KN motif and ankyrin repeat domains 2. (1027 aa)
	brca1	Uncharacterized protein. (1354 aa)
	pagr1	PAXIP1 associated glutamate-rich protein 1. (274 aa)
	ENSKMAP00000029173	CS domain-containing protein. (158 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000021859	LOC108228859	ENSKMAP00000021859	ENSKMAP00000008239	VPS11 core subunit of CORVET and HOPS complexes.	VPS11 core subunit of CORVET and HOPS complexes.	0.946
LOC108228859	ENSKMAP00000021859	ENSKMAP00000008239	ENSKMAP00000021859	VPS11 core subunit of CORVET and HOPS complexes.	VPS11 core subunit of CORVET and HOPS complexes.	0.946
LOC108237972	LOC108247437	ENSKMAP00000022094	ENSKMAP00000006911	Uncharacterized protein.	Androgen receptor.	0.901
LOC108237972	brca1	ENSKMAP00000022094	ENSKMAP00000024393	Uncharacterized protein.	Uncharacterized protein.	0.594
LOC108237972	med1	ENSKMAP00000022094	ENSKMAP00000023121	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.571
LOC108244165	LOC108249808	ENSKMAP00000014126	ENSKMAP00000010909	CCR4-NOT transcription complex subunit 9.	NOT2_3_5 domain-containing protein.	0.952
LOC108244165	cnot1	ENSKMAP00000014126	ENSKMAP00000008356	CCR4-NOT transcription complex subunit 9.	CCR4-NOT transcription complex, subunit 1.	0.980
LOC108244165	cnot2	ENSKMAP00000014126	ENSKMAP00000000773	CCR4-NOT transcription complex subunit 9.	CCR4-NOT transcription complex, subunit 2.	0.952
LOC108247437	LOC108237972	ENSKMAP00000006911	ENSKMAP00000022094	Androgen receptor.	Uncharacterized protein.	0.901
LOC108247437	brca1	ENSKMAP00000006911	ENSKMAP00000024393	Androgen receptor.	Uncharacterized protein.	0.484
LOC108247437	med1	ENSKMAP00000006911	ENSKMAP00000023121	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.571
LOC108249808	LOC108244165	ENSKMAP00000010909	ENSKMAP00000014126	NOT2_3_5 domain-containing protein.	CCR4-NOT transcription complex subunit 9.	0.952
LOC108249808	cnot1	ENSKMAP00000010909	ENSKMAP00000008356	NOT2_3_5 domain-containing protein.	CCR4-NOT transcription complex, subunit 1.	0.980
LOC108249808	cnot2	ENSKMAP00000010909	ENSKMAP00000000773	NOT2_3_5 domain-containing protein.	CCR4-NOT transcription complex, subunit 2.	0.901
LOC108249808	cnot9	ENSKMAP00000010909	ENSKMAP00000023902	NOT2_3_5 domain-containing protein.	CCR4-NOT transcription complex subunit 9.	0.952
brca1	LOC108237972	ENSKMAP00000024393	ENSKMAP00000022094	Uncharacterized protein.	Uncharacterized protein.	0.594
brca1	LOC108247437	ENSKMAP00000024393	ENSKMAP00000006911	Uncharacterized protein.	Androgen receptor.	0.484
carm1	med1	ENSKMAP00000027817	ENSKMAP00000023121	Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.509
cnot1	LOC108244165	ENSKMAP00000008356	ENSKMAP00000014126	CCR4-NOT transcription complex, subunit 1.	CCR4-NOT transcription complex subunit 9.	0.980
cnot1	LOC108249808	ENSKMAP00000008356	ENSKMAP00000010909	CCR4-NOT transcription complex, subunit 1.	NOT2_3_5 domain-containing protein.	0.980