(26 nodes) Membrane protein proteolysis network (Kryptolebias marmoratus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hm13	Histocompatibility (minor) 13. (371 aa)
	rbmx	RNA binding motif protein X-linked. (387 aa)
	LOC108249691	ADAM metallopeptidase domain 17b. (835 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (576 aa)
	LOC108236986	ADAM metallopeptidase domain 17a. (847 aa)
	adam10	Uncharacterized protein. (769 aa)
	ret	Ret proto-oncogene receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1200 aa)
	LOC108228916	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	sppl3	Signal peptide peptidase 3. (383 aa)
	clpp	ATP-dependent Clp protease proteolytic subunit. (266 aa)
	LOC108230826	Si:ch1073-396h14.1. (691 aa)
	sppl2b	Signal peptide peptidase-like 2. (598 aa)
	LOC108230196	ADAM metallopeptidase domain 10b. (783 aa)
	bace1	Beta-secretase 1; Belongs to the peptidase A1 family. (521 aa)
	dag1	Dystroglycan 1. (815 aa)
	psen2	Presenilin 2. (352 aa)
	ctsh	Cathepsin H; Belongs to the peptidase C1 family. (324 aa)
	LOC108237314	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (482 aa)
	LOC108237385	PA domain-containing protein. (530 aa)
	LOC108235256	Peptidase S72 domain-containing protein. (910 aa)
	LOC108237393	Uncharacterized protein; Belongs to the peptidase C1 family. (321 aa)
	NCSTN	Nicastrin. (701 aa)
	rhbdd1	Rhomboid domain containing 1. (327 aa)
	ENSKMAP00000028343	Uncharacterized protein. (129 aa)
	mbtps2	Membrane-bound transcription factor peptidase, site 2. (500 aa)
	bace2	Beta-secretase 2; Belongs to the peptidase A1 family. (510 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000028343	clpp	ENSKMAP00000028343	ENSKMAP00000014247	Uncharacterized protein.	ATP-dependent Clp protease proteolytic subunit.	0.430
LOC108230196	LOC108237314	ENSKMAP00000029454	ENSKMAP00000022553	ADAM metallopeptidase domain 10b.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.403
LOC108230196	NCSTN	ENSKMAP00000029454	ENSKMAP00000023807	ADAM metallopeptidase domain 10b.	Nicastrin.	0.524
LOC108230196	psen2	ENSKMAP00000029454	ENSKMAP00000015576	ADAM metallopeptidase domain 10b.	Presenilin 2.	0.403
LOC108235256	dag1	ENSKMAP00000023006	ENSKMAP00000014311	Peptidase S72 domain-containing protein.	Dystroglycan 1.	0.901
LOC108236986	LOC108249691	ENSKMAP00000009009	ENSKMAP00000003701	ADAM metallopeptidase domain 17a.	ADAM metallopeptidase domain 17b.	0.901
LOC108236986	NCSTN	ENSKMAP00000009009	ENSKMAP00000023807	ADAM metallopeptidase domain 17a.	Nicastrin.	0.436
LOC108237314	LOC108230196	ENSKMAP00000022553	ENSKMAP00000029454	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	ADAM metallopeptidase domain 10b.	0.403
LOC108237314	NCSTN	ENSKMAP00000022553	ENSKMAP00000023807	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Nicastrin.	0.992
LOC108237314	adam10	ENSKMAP00000022553	ENSKMAP00000010335	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Uncharacterized protein.	0.403
LOC108237314	bace1	ENSKMAP00000022553	ENSKMAP00000029249	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.576
LOC108237314	psen2	ENSKMAP00000022553	ENSKMAP00000015576	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin 2.	0.414
LOC108249691	LOC108236986	ENSKMAP00000003701	ENSKMAP00000009009	ADAM metallopeptidase domain 17b.	ADAM metallopeptidase domain 17a.	0.901
LOC108249691	NCSTN	ENSKMAP00000003701	ENSKMAP00000023807	ADAM metallopeptidase domain 17b.	Nicastrin.	0.436
NCSTN	LOC108230196	ENSKMAP00000023807	ENSKMAP00000029454	Nicastrin.	ADAM metallopeptidase domain 10b.	0.524
NCSTN	LOC108236986	ENSKMAP00000023807	ENSKMAP00000009009	Nicastrin.	ADAM metallopeptidase domain 17a.	0.436
NCSTN	LOC108237314	ENSKMAP00000023807	ENSKMAP00000022553	Nicastrin.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.992
NCSTN	LOC108249691	ENSKMAP00000023807	ENSKMAP00000003701	Nicastrin.	ADAM metallopeptidase domain 17b.	0.436
NCSTN	adam10	ENSKMAP00000023807	ENSKMAP00000010335	Nicastrin.	Uncharacterized protein.	0.524
NCSTN	bace1	ENSKMAP00000023807	ENSKMAP00000029249	Nicastrin.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.431