(41 nodes) Embryonic hemopoiesis network (Kryptolebias marmoratus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sh2b3	SH2B adaptor protein 3. (726 aa)
	tbx20	T-box transcription factor 20. (439 aa)
	lmo2	LIM domain only 2 (rhombotin-like 1). (160 aa)
	LOC108245667	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (388 aa)
	yap1	Yes-associated protein 1. (438 aa)
	nop10	NOP10 ribonucleoprotein homolog (yeast). (64 aa)
	LOC108228750	Uncharacterized protein. (332 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1303 aa)
	etnppl	Ethanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (490 aa)
	trim33	Tripartite motif containing 33. (1186 aa)
	LOC108240593	5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (489 aa)
	tll1	Metalloendopeptidase. (1024 aa)
	LOC108235495	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
	LOC108236587	Metalloendopeptidase. (969 aa)
	hhex	Homeobox domain-containing protein. (283 aa)
	LOC108236588	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (338 aa)
	ENSKMAP00000009463	BHLH domain-containing protein. (116 aa)
	LOC108230652	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
	ENSKMAP00000009679	Uncharacterized protein. (70 aa)
	ncoa2	Nuclear receptor coactivator. (1424 aa)
	LOC108240089	Myc target 1a. (200 aa)
	LOC108239578	T-cell acute lymphocytic leukemia 1. (385 aa)
	LOC108231541	Activating transcription factor 4a. (448 aa)
	lclat1	Lysocardiolipin acyltransferase 1. (385 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (555 aa)
	ccdc134	Si:dkey-167k11.5. (229 aa)
	LOC108236847	5-aminolevulinate synthase. (591 aa)
	chrd	Chordin; Belongs to the chordin family. (977 aa)
	ism1	Isthmin 1. (447 aa)
	bmi1	Bmi1 polycomb ring finger oncogene 1a. (346 aa)
	hdac9	Histone deacetylase 9b. (624 aa)
	slc40a1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (566 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1802 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
	LOC108247742	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (586 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	rps24	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. (132 aa)
	LOC108239241	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (681 aa)
	LOC108247801	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (557 aa)
	LOC108244378	GATA binding protein 1a. (426 aa)
	LOC108243856	Nuclear receptor coactivator. (1504 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000009463	LOC108228750	ENSKMAP00000009463	ENSKMAP00000005867	BHLH domain-containing protein.	Uncharacterized protein.	0.738
ENSKMAP00000009463	LOC108244378	ENSKMAP00000009463	ENSKMAP00000028401	BHLH domain-containing protein.	GATA binding protein 1a.	0.738
ENSKMAP00000009463	lmo2	ENSKMAP00000009463	ENSKMAP00000002065	BHLH domain-containing protein.	LIM domain only 2 (rhombotin-like 1).	0.957
LOC108228750	ENSKMAP00000009463	ENSKMAP00000005867	ENSKMAP00000009463	Uncharacterized protein.	BHLH domain-containing protein.	0.738
LOC108228750	LOC108236847	ENSKMAP00000005867	ENSKMAP00000019404	Uncharacterized protein.	5-aminolevulinate synthase.	0.444
LOC108228750	LOC108239578	ENSKMAP00000005867	ENSKMAP00000013785	Uncharacterized protein.	T-cell acute lymphocytic leukemia 1.	0.738
LOC108228750	lmo2	ENSKMAP00000005867	ENSKMAP00000002065	Uncharacterized protein.	LIM domain only 2 (rhombotin-like 1).	0.933
LOC108230652	PRKCB	ENSKMAP00000009546	ENSKMAP00000024100	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.900
LOC108236587	chrd	ENSKMAP00000008010	ENSKMAP00000019463	Metalloendopeptidase.	Chordin; Belongs to the chordin family.	0.839
LOC108236587	yap1	ENSKMAP00000008010	ENSKMAP00000005198	Metalloendopeptidase.	Yes-associated protein 1.	0.408
LOC108236588	LOC108236847	ENSKMAP00000008749	ENSKMAP00000019404	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	5-aminolevulinate synthase.	0.578
LOC108236588	slc40a1	ENSKMAP00000008749	ENSKMAP00000021807	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	0.442
LOC108236847	LOC108228750	ENSKMAP00000019404	ENSKMAP00000005867	5-aminolevulinate synthase.	Uncharacterized protein.	0.444
LOC108236847	LOC108236588	ENSKMAP00000019404	ENSKMAP00000008749	5-aminolevulinate synthase.	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.578
LOC108236847	LOC108244378	ENSKMAP00000019404	ENSKMAP00000028401	5-aminolevulinate synthase.	GATA binding protein 1a.	0.498
LOC108239241	PRKCA	ENSKMAP00000025930	ENSKMAP00000023137	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.900
LOC108239578	LOC108228750	ENSKMAP00000013785	ENSKMAP00000005867	T-cell acute lymphocytic leukemia 1.	Uncharacterized protein.	0.738
LOC108239578	LOC108244378	ENSKMAP00000013785	ENSKMAP00000028401	T-cell acute lymphocytic leukemia 1.	GATA binding protein 1a.	0.738
LOC108239578	lmo2	ENSKMAP00000013785	ENSKMAP00000002065	T-cell acute lymphocytic leukemia 1.	LIM domain only 2 (rhombotin-like 1).	0.967
LOC108243856	med1	ENSKMAP00000028801	ENSKMAP00000023121	Nuclear receptor coactivator.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.660