STRINGSTRING
WDR70 WDR70 pnkp pnkp smarcad1 smarcad1 poll poll rad18 rad18 parp3 parp3 LOC108244389 LOC108244389 LOC108235614 LOC108235614 sirt7 sirt7 polh polh LOC108241508 LOC108241508 LOC108235131 LOC108235131 rnf8 rnf8 Rbbp8 Rbbp8 rec114 rec114 timeless timeless nhej1 nhej1 actr2 actr2 rpa3 rpa3 smchd1 smchd1 vcp vcp arpc3 arpc3 rad51 rad51 parp1 parp1 LOC108245834 LOC108245834 prpf19 prpf19 hus1 hus1 rad50 rad50 mre11 mre11 xrcc4 xrcc4 tonsl tonsl LOC108243478 LOC108243478 tp53bp1 tp53bp1 sirt6 sirt6 ARPC4 ARPC4 wrap53 wrap53 LOC108244717 LOC108244717 slf1 slf1 ACTR3 ACTR3 ufl1 ufl1 arpc2 arpc2 shld2 shld2 rif1 rif1 ddb1 ddb1 paxx paxx aplf aplf LOC108249093 LOC108249093
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WDR70WD repeat domain 70. (595 aa)
pnkpPolynucleotide kinase 3'-phosphatase. (590 aa)
smarcad1Uncharacterized protein. (1062 aa)
pollPolymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (571 aa)
rad18RAD18 E3 ubiquitin protein ligase. (490 aa)
parp3Poly [ADP-ribose] polymerase. (530 aa)
LOC108244389SET domain and mariner transposase fusion gene. (287 aa)
LOC108235614Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (169 aa)
sirt7Sirtuin 7. (406 aa)
polhPolymerase (DNA directed), eta. (738 aa)
LOC108241508Zgc:136908; Belongs to the AAA ATPase family. (808 aa)
LOC108235131SAM domain and HD domain 1. (624 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (515 aa)
Rbbp8SAE2 domain-containing protein. (82 aa)
rec114Uncharacterized protein. (180 aa)
timelessTimeless circadian clock. (1247 aa)
nhej1Nonhomologous end-joining factor 1. (308 aa)
actr2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
rpa3Replication protein A 14kDa subunit. (122 aa)
smchd1Structural maintenance of chromosomes flexible hinge domain containing 1. (1800 aa)
vcpValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
arpc3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (221 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (334 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
LOC108245834Uncharacterized protein. (246 aa)
prpf19Pre-mRNA processing factor 19. (505 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (696 aa)
xrcc4X-ray repair complementing defective repair in Chinese hamster cells 4. (343 aa)
tonslTonsoku-like, DNA repair protein. (1413 aa)
LOC108243478Uncharacterized protein; Belongs to the actin family. (418 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1702 aa)
sirt6Sirtuin 6. (350 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
wrap53WD repeat containing, antisense to TP53. (547 aa)
LOC108244717Uncharacterized protein. (1332 aa)
slf1SMC5-SMC6 complex localization factor 1. (879 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
ufl1UFM1-specific ligase 1. (780 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (301 aa)
shld2Si:ch211-134m17.9. (559 aa)
rif1Replication timing regulatory factor 1. (2345 aa)
ddb1Damage-specific DNA binding protein 1. (1075 aa)
paxxPAXX non-homologous end joining factor. (191 aa)
aplfUncharacterized protein. (413 aa)
LOC108249093Zgc:101810; Belongs to the actin family. (394 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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